Macrophages are “big eaters” in our body; they are immune cells that engulf and kill invading organisms and cancer cells. Macrophages are present in the living ecosystem of many types of cancer. Using digital imaging, bioinformatics, and machine learning techniques, research led by N2CR member, Dr Anand Jeyasekharan, discovered 6 different macrophage signatures (MacroSigs) that can help distinguish types of macrophages in normal lymph nodes and diffuse large B-cell lymphoma (DLBCL), a tumour arising from our lymph nodes. This groundbreaking discovery helps doctors understand the evolution of this disease and how some DLBCL tumours relapse after chemotherapy. 

Read more: https://www.nature.com/articles/s41467-024-46220-z