Primary Epstein-Barr virus (EBV)-positive nodal T/NK-cell lymphoma (PTCL-EBV) is an aggressive and poorly understood disease that occurs mostly in East Asia. In this collaborative study, led by A/Prof Ng Siok Bian and Dr Jason Pitt, the authors and their team characterise PTCL-EBV as an aggressive lymphoma with minimal genomic instability, immune-related gene expression and activation of NFκB along with its associated genes. These findings afford both novel insight into the pathogenesis of this disease and highlight new potential targets for therapeutic development.

Read more: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335103/