Multiple primary cancers (MPC) often indicate a hereditary cancer predisposition syndrome. In a study led by Prof Lee Soo Chin, 19% of 3514 cancer patients who underwent germline genetic testing through a cancer genetics clinic had MPC and 29.4% of these MPC patients tested positive for at least one pathogenic germline variants (PGVs), compared to 20.8% positivity rate among patients with single primary cancer. PGVs are inherited genetic mutations that increase the risk of developing certain diseases, including cancer.

The findings underscore the importance of comprehensive genetic testing for MPC patients to better identify and manage hereditary cancer risks. This approach will refine genetic testing, enhance early detection, personalise cancer treatment and prevention strategies, thereby advancing the field of precision medicine.

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