A study led by Dr Alan Prem Kumar, a member of N2CR, delves into how cancer arises from disruptions in cell cycle regulation, driven by mutations that fuel unchecked division or disable critical control mechanisms such as apoptosis. Remarkably, tumours exploit functional checkpoints like DNA damage and mitotic checkpoints to persist despite accumulating genetic errors. Their study illuminates cutting-edge therapeutic strategies targeting these tumour dependencies, paving the way for innovative treatments to disrupt cancer progression and improve patient outcomes.

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