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In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls
This study, led by N2CR members Dr Joline Lim and A/Prof David Tan, looks at the use of next-generation sequencing (NGS) for molecular profiling of metastatic breast cancer (MBC) in
Cell cycle dysregulation, a key feature of cancer, leads to excessive cell division. CDK4 and CDK6 are essential for cell cycle transition and crucial in breast cancer. Inhibitors for these
Macrophages are “big eaters” in our body; they are immune cells that engulf and kill invading organisms and cancer cells. Macrophages are present in the living ecosystem of many types
When a cell divides to make new cells, it needs to copy its DNA so that each new cell has the same genetic information. This process is called DNA replication.
Glioblastoma is the most common and lethal form of adult brain cancer. The presence of cancer stem cells (so-called glioma stem cells) within the tumour, makes it difficult to eradicate
N2CR researchers led by Prof Ashok Venkitaraman and Dr Kong Li Ren have unearthed new findings which may help explain the connection between cancer risk and poor diet, as well
In exploring the relationship between viruses in the gut and colorectal cancer (CRC), researchers led by A/Prof Tan Ker Kan and Dr Law Jia Hao collected stool samples from non-cancer
Oncogenic mutations of KRAS are associated with a host of human malignancies, in particular, pancreatic, colorectal and lung cancer. Therefore, there is heightened interest in the design and development of
N2CR members Associate Professor Alfredo Franco-Obregon and Dr. Alex Tai Yee Kit discovered that subjecting skeletal muscle to brief and non-invasive magnetic fields stimulated their secretion of anticancer factors. These