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A breakthrough study, co-led by N2CR member A/Prof Raghav Sundar and includes Prof Jimmy So, A/Prof Yvonne Tay and Dr Yong Wei Peng, has provided new hope for gastric cancer
Multiple myeloma is a cancer of plasma cells, and its development and therapy resistance remain poorly understood. This study led by N2CR members, Prof Chng Wee Joo and Dr Zhou
This study co-led by N2CR member A/Prof Gautam Sethi, investigates the effects of CHL-C (an imidazopyridine-tethered chalcone) on colorectal cancer (CRC). CHL-C was shown to induce apoptosis and autophagy in
This study explores CD151’s (a protein linked to cancer progression) role in non-small cell lung cancer (NSCLC) patients without EGFR mutations, who have limited treatment options. Analysing 157 adenocarcinoma biopsies
In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls
This study, led by N2CR members Dr Joline Lim and A/Prof David Tan, looks at the use of next-generation sequencing (NGS) for molecular profiling of metastatic breast cancer (MBC) in
Cell cycle dysregulation, a key feature of cancer, leads to excessive cell division. CDK4 and CDK6 are essential for cell cycle transition and crucial in breast cancer. Inhibitors for these
Macrophages are “big eaters” in our body; they are immune cells that engulf and kill invading organisms and cancer cells. Macrophages are present in the living ecosystem of many types
When a cell divides to make new cells, it needs to copy its DNA so that each new cell has the same genetic information. This process is called DNA replication.
Glioblastoma is the most common and lethal form of adult brain cancer. The presence of cancer stem cells (so-called glioma stem cells) within the tumour, makes it difficult to eradicate