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This research, led by N2CR members Prof Goh Boon Cher and Prof Shazib Pervaiz with Dr Jayshree Hirpara as the first author, investigates the role of extracellular vesicles (EVs) in
Detecting cancer-driving mutations is crucial for understanding cancer and developing treatments. Existing prediction tools vary in accuracy. N2CR member A/Prof Chen Ee Sin co-led the study on DriverDetect, a machine
Led by N2CR member A/Prof Polly Chen, this research highlights the crucial role of ‘death associated protein 3’ (DAP3) in regulating N6-methyladenosine (m6A) RNA methylation, a process often disrupted in
Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) is challenging to treat. Outcome for such patients is dismal. A recent experimental treatment – using CD7 CAR T-cell therapy, developed by N2CR member
A breakthrough study, co-led by N2CR member A/Prof Raghav Sundar and includes Prof Jimmy So, A/Prof Yvonne Tay and Dr Yong Wei Peng, has provided new hope for gastric cancer
Multiple myeloma is a cancer of plasma cells, and its development and therapy resistance remain poorly understood. This study led by N2CR members, Prof Chng Wee Joo and Dr Zhou
This study co-led by N2CR member A/Prof Gautam Sethi, investigates the effects of CHL-C (an imidazopyridine-tethered chalcone) on colorectal cancer (CRC). CHL-C was shown to induce apoptosis and autophagy in
This study explores CD151’s (a protein linked to cancer progression) role in non-small cell lung cancer (NSCLC) patients without EGFR mutations, who have limited treatment options. Analysing 157 adenocarcinoma biopsies
In this study, led by A/Prof Polly Chen, multi-omics approaches revealed that MDA5 loss in ADAR1-deficient livers does not reduce inflammation and dysfunction. Hepatocyte-macrophage interaction via the PGRN-EGFR axis controls
This study, led by N2CR members Dr Joline Lim and A/Prof David Tan, looks at the use of next-generation sequencing (NGS) for molecular profiling of metastatic breast cancer (MBC) in