Soong Tuck Wah

Soong Tuck Wah

PhD

Professor

+65-6516 1938 (Office);
+65-6516 3395 (Lab)

+65-6778 8161 / +65-6777 3271

phsstw@nus.edu.sg

Ion Channel and Transporter Laboratory

Affiliations

  • Professor, Department of Physiology, National University of Singapore
  • Principal Investigator, Healthy Longevity and Cardiovascular Translational Research Programmes
  • Senior Faculty, LSI Neurobiology Programme
  • Visiting Professor, Xiamen Cardiac Hospital, Xiamen University
  • Distinguished Visiting Scientist, National Neuroscience Institute

Research Areas of Interest:

  • Investigations into diversification of calcium channel function via alternative splicing and RNA editing and their implications in neurological disorders such as anxiety or fear and in cardiovascular disorders such as hypertension and heart failure.
  • Investigations into physiological significance of alternative splicing and RNA editing of CaV channels in hippocampal learning and memory and cerebellar motor learning, and in feeding behavior and circadian rhythm.
  • Investigations into the implications of functional coupling between galectin-1, galectin-3 or filamin A and Cav1.2 channel in the cardiovascular system, and in heart failure and hypertension.

Selected Publications

  1. Hu Z, Zhang B, Lim LJY, Loh WZK, Yu D, Tan BWQ, Liang MC, Huang Z, Leo CH, Huang H, Soong TW. S-Nitrosylation-Mediated Reduction of Cav1.2 Surface Expression and Open Probability Underlies Attenuated Vasoconstriction Induced by Nitric Oxide. Hypertension. 2022 Dec;79(12):2854-2866
  2. Hu Z, Li G, Wang JW, Chong SY, Yu D, Wang X, Soon JL, Liang MC, Wong YP, Huang N, Colecraft HM, Liao P, Soong TW. Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction. Circulation. 2018 Oct 2;138(14):1431-1445.
  3. Huang H, Kapeli K, Jin W, Wong YP, Arumugam TV, Koh JH, Srimasorn S, Mallilankaraman K, Chua JJE, Yeo GW, Soong TW. Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Nucleic Acids Res. 2018 Aug 21;46(14):7323-7338.
  4. Huang H, Ng CY, Yu D, Zhai J, Lam Y, Soong TW. Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent. Nat Commun. 2014 Jul 24;5:4481. (Faculty 1000/Prime)
  5. Huang H, Tan BZ, Shen Y, Tao J, Jiang F, Sung YY, Ng CK, Raida M, Köhr G, Higuchi M, Fatemi-Shariatpanahi H, Harden B, Yue DT, Soong TW. RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation. Neuron. 2012 Jan 26;73(2):304-16. (Faculty 1000/Biology)
  6. Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction. Circ Res. 2011 Nov 11;109(11):1250-8.
  7. Ryan DP, da Silva MR, Soong TW, Fontaine B, Donaldson MR, Kung AW, Jongjaroenprasert W, Liang MC, Khoo DH, Cheah JS, Ho SC, Bernstein HS, Maciel RM, Brown RH Jr, Ptácek LJ. Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis. Cell. 2010 Jan 8;140(1):88-98. (Faculty 1000/Biology)
  8. DeMaria CD, Soong TW, Alseikhan BA, Alvania RS, Yue DT. Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. Nature. 2001 May 24;411(6836):484-9.
  9. Bourinet E, Soong TW, Sutton K, Slaymaker S, Mathews E, Monteil A, Zamponi GW, Nargeot J, Snutch TP. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci. 1999 May;2(5):407-15.
  10. Soong TW, Stea A, Hodson CD, Dubel SJ, Vincent SR, Snutch TP. Structure and functional expression of a member of the low voltage-activated calcium channel family. Science. 1993 May 21;260(5111):1133-6.

Awards

  • 1992-1995 IMCB postdoctoral Fellowship
  • 1999 NMRC Medical Research Scientist Award
  • 2005 Alberta Heritage Foundation Medical Research Visiting Lecture Award
  • 2006 UK-Singapore Partners in Science Collaboration Award
  • 2007 Yong Loo Lin School of Medicine Research Excellence Award, 2005/06
  • 2011 NUHS Academic Medicine Development Award (AMDA) Award
  • 2012 NGS Teaching Commendation Award
  • 2012 WHB-SMA Outstanding Mentor Award
  • 2013 Singapore Neuroscience Association “Excellence in Neuroscience Award”
  • 2014 NUS Faculty Research Excellence Award AY2012/2013
  • 2016 NUS Faculty Outstanding Research Award AY2014/15
  • 2016 Association for the Study of Neuron and Disease (AND) Investigator Award
  • 2016 Dr C.S. Paulose Research Excellence Award, India
  • 2023 Inspiring Mentor Award, NUS High School for Maths and Science
  • 2024 The First Nanjing Medical University Tianyuan Forum: Series of Lectures by 100, Distinguished Scholars on Campus and 90th Anniversary Academic Forum
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