Research Areas of Interest (Discipline):

• Targeting XIAP for neuroblastoma treatment
• Monitoring disease and evaluating MRD in pediatric cancers
• Characterizing genetic landscape of neuroblastoma
• Mechanisms of neuroblastoma pathogenesis

Research Areas of Interest (Education):

• Medical sciences in clinical reasoning and decision-making
• Interdisciplinary and transdisciplinary learning
• Faculty development and evaluation
• Student and faculty mentoring

Selected Publications (Education and Discipline)

• Loh, A., Angelina, C., Wong, M. K., Tan, S. H., Sukhatme, S. A., Yeo, T., Lim, S. B., Lee, Y. T., Soh, S. Y., Leung, W., Chang, K., Chua, Y. W., Alkaff, S., Lim, T., Lim, C. T., & Chen, Z. X. (2022). Pro-metastatic and mesenchymal gene expression signatures characterize circulating tumor cells of neuroblastoma patients with bone marrow metastases and relapse. Frontiers in oncology, 12, 939460. 
• Kuick, C. H., Tan, J. Y., Jasmine, D., Sumanty, T., Ng, A., Venkatesh, B., Chen, H., Loh, E., Jain, S., Seow, W. Y., Ng, E., Lian, D., Soh, S. Y., Chang, K., Chen, Z. X., & Loh, A. (2022). Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma. BMC cancer, 22(1), 717.
• Wong, R. L. Y., Wong, M. R. E., Kuick, C. H., Saffari, S. E., . . . Chen, Z. X., Iyer, P., Tan, E. E. K., Soh, S. Y., Iyer, N. G., Fan, Q., and Loh, A. H. P. (2021). Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma. Front Oncol, 11, 709525.
• Hee, E., Wong, M. K., Tan, S. H., Choo, Z., . . . Chen, Z., Chang, K. T. E., and Loh, A. H. P. (2020). Neuroblastoma patient-derived cultures are enriched for a mesenchymal gene signature and reflect individual drug response. Cancer Sci, 111(10), 3780-3792.
• Choo, Z., Loh, A. H. P., and Chen, Z. X. (2019). Destined to Die: Apoptosis and Pediatric Cancers. Cancers, 11(11), 1623.
• Angelina, C., Tan, I. S. Y., Choo, Z., Lee, O. Z. J., Pervaiz, S., and Chen, Z. X. (2017). KIF1Bbeta increases ROS to mediate apoptosis and reinforces its protein expression through O 2(-) in a positive feedback mechanism in neuroblastoma. Sci Rep, 7(1), 16867.
• Cai, W., Xiong Chen, Z.#, Rane, G., Satendra Singh, S., Choo, Z., Wang, C., . . . Prem Kumar, A. (2017). Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. J Natl Cancer Inst, 109(6). #co-first authors
• Li, S., Fell, S. M., Surova, O., Smedler, E., Wallis, K., Chen, Z. X., . . . Schlisio, S. (2016). The 1p36 Tumor Suppressor KIF 1Bbeta Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. Dev Cell, 36(2), 164-178.
• Chen, Z. X., Wallis, K., Fell, S. M., Sobrado, V. R., Hemmer, M. C., Ramskold, D., . . . Schlisio, S. (2014). RNA helicase A is a downstream mediator of KIF1Bbeta tumor-suppressor function in neuroblastoma. Cancer Discov, 4(4), 434-451.
• Jain, S. R., Sui, Y., Ng, C. H., Chen, Z. X., Goh, L. H., and Shorey, S. (2020). Patients’ and healthcare professionals’ perspectives towards technology-assisted diabetes self-management education. A qualitative systematic review. PLoS One, 15(8), doi: 10.1371/journal.pone.0237647
• Chen, Z. X., Lee, S. S., Samarasekera, D. D., and Stalmeijer, R. (2020). Inter-related issues that impact motivation in biomedical sciences graduate education. TAPS, 5(3), 10-19. doi.org/10.29060/TAPS.2020-5-3/OA2113
• Luke, W. A. N. V., Lee, S. C., Ban, K. H. K., Wong, A. H. P., Chen, Z. X., Lee, S. S., Taneja, R., Samarasekera, D. D., Yap, C. T. S. M. (2024). Is ChatGPT ‘ready’ to be a learning tool for medical undergraduates and will it perform equally in different subjects? – Comparative study of ChatGPT performance in tutorial and case-based learning questions in Physiology and Biochemistry. Med Teach, Jan 31:1-7. doi: 10.1080/0142159X.2024.2308779. Online ahead of print.
• Lee, S. S., Indran, I. R., Yap, C. T., Samarasekera, D. D., Wong, S. J. Y., and Chen, Z. X. (2022). Enhancing the use of peer review and student feedback to evaluate educators in early years of health professions education: insights from a medical school. Singapore Med J, May 5. doi: 10.11622/smedj.2022051. Online ahead of print.
• Gwee, M. C. E., Samarasekera, D. D., and Chen, Z. X. (2021). Curriculum Organisation: ‘Why Can’t I Just Teach What I Know?’. In D. D. Samarasekera (Ed.) and M. C. E. Gwee (Ed.), Educate, Train and Transform: Toolkit on Medical and Health Professions Education (pp. 15-32). Hackensack, NJ: World Scientific.