Tsuyoshi Hirashima

Tsuyoshi Hirashima

PhD

Assistant Professor

+65-6601 1285

thira@nus.edu.sg

Collective Cell Dynamics Laboratory

ORCID

Affiliations

  • Assistant Professor, Department of Physiology, National University of Singapore
  • Principal Investigator, Mechanobiology Institute

Research Areas of Interest:

  • Emergent property of collective cell behaviors in epithelial tissues
  • Biophysical understanding of sperm-epithelial interaction in male reproduction
  • Mathematical modeling of multicellular tissue dynamics

Selected Publications

  1. Tsuyoshi Hirashima* and Michiyuki Matsuda. ERK-mediated Curvature Feedback Regulates Branching Morphogenesis in Lung Epithelial Tissue. Current Biology, doi.org/10.1016/j.cub.2023.12.049, 2024.
  2. Ankita Nitin Nayak and Tsuyoshi Hirashima*. Tug-of-War via ERK Signaling Pathway for Tissue Organization – ERK Activation to Force Generation. Current Opinion in Cell Biology, doi: 10.1016/j.ceb.2023.102249, 2023.
  3.  Veronica Lee Xi Min, Barry T. Hinton, Tsuyoshi Hirashima*. Collective Cell Dynamics and Luminal Fluid Flow in the Epididymis: A Mechanobiological Perspective. Andrology, doi: 10.1111/andr.13490, 2023.
  4. Akihito Kira, Ichiko Tatsutomi†, Keisuke Saito†, Machiko Murata†, Izumi Hattori, Haruna Kajita, Naoko Muraki, Yukako Oda, Saya Satoh, Yuta Tsukamoto, Seisuke Kimura, Kenta Onoue, Shigenobu Yonemura, Satoko Arakawa, Hiroki Kato, Tsuyoshi Hirashima*, and Kohki Kawane*. Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion. Developmental Cell, 58, 1–17, doi: 10.1016/j.devcel.2023.05.008, 2023.
  5. Daniel Boocock, Tsuyoshi Hirashima, Edouard Hannezo*. Interplay between mechanochemical patterning and glassy dynamics in cellular monolayers. PRX Life, doi: 10.1103/PRXLife.1.013001, 2023.
  6. Chii Jou Chan* and Tsuyoshi Hirashima*. Tissue hydraulics in reproduction. Seminars in Cell and Developmental Biology, doi: 10.1016/j.semcdb.2022.05.008, 2022.
  7. Yuta Kanazawa, Takuya Omotehara*, Hiroki Nakata, Tsuyoshi Hirashima, Masahiro Itoh. Three-dimensional analysis and in vivo imaging for sperm release and transport in the murine seminiferous tubule. Reproduction, 164, pp9-18, doi: 10.1530/REP-21-0400, 2022.
  8. Mamoru Ishii, Tomoko Tateya, Michiyuki Matsuda, Tsuyoshi Hirashima*. Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis. eLife, 10:e61092, 2021.
  9. Daniel Boocock#, Naoya Hino#, Natalia Ruzickoval, Tsuyoshi Hirashima*, Edouard Hannezo*. Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics. doi:10.1038/s41567-020-01037-7, 2021.
  10. Naoya Hino, Leone Rossetti, Ariadna Marín-Llauradó, Kazuhiro Aoki, Xavier Trepat, Michiyuki Matsuda*, Tsuyoshi Hirashima*. ERK-mediated mechanochemical waves direct collective cell polarization. Developmental Cell, doi: 10.1016/j.devcel.2020.05.011, 2020.

Awards

  • 2024 JSDB Frontiers Prize, Japanese Society of Developmental Biologists
  • 2023 Young Scientist Award, Ministry of Education, Culture, Sports, Science and Technology of Japan
  • 2019 PRESTO Fellowship, Japan Science and Technology
  • 2017 Early Career Award, The Biophysical Society of Japan
  • 2012 Post-doctoral Research Fellowship (PD), Japan Society for the Promotion of Science
  • 2009 Pre-doctoral Research Fellowship (DC2), Japan Society for the Promotion of Science
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