Shazib Pervaiz

Shazib Pervaiz

MBBS, Ph.D.

Professor

6516 6602(Office);
6516 3229(Lab)

phssp@nus.edu.sg

ROS Biology & Apoptosis Lab

ORCID

Affiliations

  • Professor, Department of Physiology, National University of Singapore
  • NUS Centre for Cancer Research Translational Research Programme

Research Areas of Interest:

  • Regulation of Cell Death Signaling in Cancer Cells
  • Reactive Oxygen Species and Cell Fate
  • Bcl-2 Family and Mitochondrial Metabolism
  • Protein Phosphatase PP2A and Cancer
  • Autophagy and Cancer
  • Experimental Therapeutics

Selected Publications

  1. Kartini Iskandar, Jonathan Foo, Angeline Qiu Xia Liew, Haiyuxin Zhu, Deepika Raman, Jayshree L. Hirpara, Yan Yi Leong, Maria V. Babak, Anna A. Kirsanova, Anne-Sophie Armand, Franck Oury, Gregory Bellot, and Shazib Pervaiz. A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS, Autophagy, 2024, VOL. 20, NO. 6, 1418–1441
  2. Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, Valentin R, Herbaux C, Collins M, Low ICC, Loh T, Davids M, Pervaiz S. Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism. Nucleic Acids Research. 2020 Dec 16;48(22):12727-12745. doi: 10.1093/nar/gkaa1110
  3. Raman D, Chong SJF, Iskandar K, Hirpara JL, Pervaiz S. Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc. Redox Biol. 2020 Jul;34:101587. doi: 10.1016/j.redox.2020.101587
  4. Chong SJF, Lai JXH, Qu JH, Hirpara JL, Kang J, Swaminathan K, Loh T, Kumar A, Vali S, Abbasi T and Pervaiz, S. A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression. Cancer Letts. 2019 Aug 10; 457:151-167. doi: 10.1016/j.canlet.2019.05.009.
  5. Loo SY, Pandey VK, Tan TZ, Thiery JP, Yap CT, Goh BC, Lobie PE, Pervaiz S*, Clement M-V, Kumar AP. Reversibility of Epithelial Mesenchymal Transition in triple negative Breast Cancer via modulation of MnSOD-mediated reactive oxygen species signaling. Redox Signal. 2016 Aug 20;25(6):283-99. doi: 10.1089/ars.2015.6524. *Joint corresponding author.
  6. Iskandar K, Rezlan M, Yadav S, Foo Chuan Han J, Sethi G, Qiang Y, Bellot G, and Pervaiz S. Synthetic lethality of a novel small molecule against mutant KRAS expressing cancer cells involves AKT-dependent ROS production. Redox Signal. 10;24(14):781-94, 2016.
  7. Low IC, Loh T, Huang Y, Virshup DM, and Pervaiz S. Sustained Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity. Blood, 124(14):2223-34, 2014. (*Commentary by S. Nakahata and K. Morishita in the same issue).
  8. Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S*, Clement MV*. Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast cancer. Redox Signal, 20(15):2326-46, 2014 (*joint senior author).
  9. Zhu Y, Casey PJ, Kumar AP, Pervaiz S. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. Cell Death Disease. 4:e568. doi: 10.1038/cddis.2013.103, 2013.
  10. Velaithan R, Kang J, Hirpara JL, Loh T, Goh BC, Le Bras M, Brenner C, Clement MV, and Pervaiz S. The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity. Blood. 9;117(23):6214-26, 2011.
  11. Indran IR, Hande MP, Pervaiz S. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Research. 1;71(1):266-76, 2011. (Discussed in highlights in cancer literature under breaking advances. Cancer Research, 71, 1-2, 2011).
  12. Chen ZX, and Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 17(3):408-20, 2010.
  13. Poh TW, Huang S, Hirpara JL, and Pervaiz S. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. Cell Death Diff. 14(10): 1813-25, 2007.
  14. Chen, Z, X. and Pervaiz, S. Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Diff. 14(9): 1617-27, 2007.
  15. Clement, M-V., Hirpara, J.L., and Pervaiz, S. Decrease in intracellular superoxide sensitizes Bcl-2 overexpressing tumor cells to receptor- and drug-induced apoptosis independent of the mitochondria. Cell Death Diff. 10(11):1273-85, 2003.

Awards

  • 2023 Graduate Mentor of the Year Award (GRAMAY)
  • 2001-2002 Faculty of Medicine Outstanding Researcher Award, NUS
  • 2004 Faculty of Medicine Outstanding Researcher Award (Dean’s Citation), NUS
  • 2004 University Teaching Excellence Award, NUS
  • 2003/2004 Faculty of Medicine Teaching Excellence Award, NUS
  • 2005 University Outstanding Researcher Award, NUS
  • 2006 Faculty of Science Teaching Excellence Award, NUS
  • 2006 Raine Visiting Professor, University of Western Australia, Perth, Australia
  • 2012-13 Membership of Academy, European Cell Death Organization (ECDO)
  • 2015 Swee Liew-Wadsworth Research Award 2015, Department of Physiology, NUS
  • 2015 Swee Liew-Wadsworth Intra-Department and Concept Grants, Department of Physiology, NUS
  • 2015 Swee Liew-Wadsworth Concept Grants 2015, Department of Physiology, NUS
  • 2015-present Distinguished Visiting Fellow, Curtin University, Perth, Australia
  • 2018 Swee Liew-Wadsworth Research Publication Award 2018 , Department of Physiology, NUS (Platinum and Silver)
  • June 2018 Board Member, International Cell Death Society (ICDS)
  • September 2018-present Visiting Professor, Sichuan University, Chengdu, China
  • 2019 Swee Liew-Wadsworth Research Publication Award 2019, Department of Physiology, NUS (Silver)
  • June-August 2019 Visiting Professor, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (host: Dr. Matthew Davids)
  • September 2019-present Guest Professor, University of Shenzhen, Shenzhen, China
  • September 2019-present Adjunct Professor, University of Paris Descartes, Paris, France
  • 2020 Swee Liew-Wadsworth Concept Grants 2020, Department of Physiology, NUS
  • 2020 Swee Liew-Wadsworth Research Publication Awards for 2020 (Silver)
  • 2020 Swee Liew-Wadsworth Research Publication Awards for 2020 (Gold)
  • 2020 NUS Medicine Fortitude Award 2020
  • 2021 Swee Liew-Wadsworth Concept Grants 2021, Department of Physiology, NUS