Shazib Pervaiz

Shazib Pervaiz

MBBS, Ph.D.

Professor

6516 6602(Office);
6516 3229(Lab)

phssp@nus.edu.sg

ROS Biology & Apoptosis Lab

ORCID

Affiliations

  • Professor, Department of Physiology, National University of Singapore
  • NUS Centre for Cancer Research Translational Research Programme

Research Areas of Interest:

  • Regulation of Cell Death Signaling in Cancer Cells
  • Reactive Oxygen Species and Cell Fate
  • Bcl-2 Family and Mitochondrial Metabolism
  • Protein Phosphatase PP2A and Cancer
  • Autophagy and Cancer
  • Experimental Therapeutics

Selected Publications

  1. Kartini Iskandar , Jonathan Foo , Angeline Qiu Xia Liew, HaiClement, M-V., Hirpara, J., Chowdhury, S., and Pervaiz, S. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95-signaling dependent apoptosis in human tumor cells. Blood, 92(3):996-1002, 1998.
  2. Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, Valentin R, Herbaux C, Collins M, Low ICC, Loh T, Davids M, Pervaiz S. Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism. Nucleic Acids Research. 2020 Dec 16;48(22):12727-12745. doi: 10.1093/nar/gkaa1110
  3. Raman D, Chong SJF, Iskandar K, Hirpara JL, Pervaiz S. Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc. Redox Biol. 2020 Jul;34:101587. doi: 10.1016/j.redox.2020.101587
  4. Chong SJF, Lai JXH, Qu JH, Hirpara JL, Kang J, Swaminathan K, Loh T, Kumar A, Vali S, Abbasi T and Pervaiz, S. A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression. Cancer Letts. 2019 Aug 10; 457:151-167. doi: 10.1016/j.canlet.2019.05.009.
  5. Loo SY, Pandey VK, Tan TZ, Thiery JP, Yap CT, Goh BC, Lobie PE, Pervaiz S*, Clement M-V, Kumar AP. Reversibility of Epithelial Mesenchymal Transition in triple negative Breast Cancer via modulation of MnSOD-mediated reactive oxygen species signaling. Redox Signal. 2016 Aug 20;25(6):283-99. doi: 10.1089/ars.2015.6524. *Joint corresponding author.
  6. Iskandar K, Rezlan M, Yadav S, Foo Chuan Han J, Sethi G, Qiang Y, Bellot G, and Pervaiz S. Synthetic lethality of a novel small molecule against mutant KRAS expressing cancer cells involves AKT-dependent ROS production. Redox Signal. 10;24(14):781-94, 2016.
  7. Low IC, Loh T, Huang Y, Virshup DM, and Pervaiz S. Sustained Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity. Blood, 124(14):2223-34, 2014. (*Commentary by S. Nakahata and K. Morishita in the same issue).
  8. Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S*, Clement MV*. Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast cancer. Redox Signal, 20(15):2326-46, 2014 (*joint senior author).
  9. Zhu Y, Casey PJ, Kumar AP, Pervaiz S. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. Cell Death Disease. 4:e568. doi: 10.1038/cddis.2013.103, 2013.
  10. Velaithan R, Kang J, Hirpara JL, Loh T, Goh BC, Le Bras M, Brenner C, Clement MV, and Pervaiz S. The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity. Blood. 9;117(23):6214-26, 2011.
  11. Indran IR, Hande MP, Pervaiz S. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Research. 1;71(1):266-76, 2011. (Discussed in highlights in cancer literature under breaking advances. Cancer Research, 71, 1-2, 2011).
  12. Chen ZX, and Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 17(3):408-20, 2010.
  13. Poh TW, Huang S, Hirpara JL, and Pervaiz S. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. Cell Death Diff. 14(10): 1813-25, 2007.
  14. Chen, Z, X. and Pervaiz, S. Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Diff. 14(9): 1617-27, 2007.
  15. Clement, M-V., Hirpara, J.L., and Pervaiz, S. Decrease in intracellular superoxide sensitizes Bcl-2 overexpressing tumor cells to receptor- and drug-induced apoptosis independent of the mitochondria. Cell Death Diff. 10(11):1273-85, 2003.

Awards

  • 2023 Graduate Mentor of the Year Award (GRAMAY)
  • 2001-2002 Faculty of Medicine Outstanding Researcher Award, NUS
  • 2004 Faculty of Medicine Outstanding Researcher Award (Dean’s Citation), NUS
  • 2004 University Teaching Excellence Award, NUS
  • 2003/2004 Faculty of Medicine Teaching Excellence Award, NUS
  • 2005 University Outstanding Researcher Award, NUS
  • 2006 Faculty of Science Teaching Excellence Award, NUS
  • 2006 Raine Visiting Professor, University of Western Australia, Perth, Australia
  • 2012-13 Membership of Academy, European Cell Death Organization (ECDO)
  • 2015 Swee Liew-Wadsworth Research Award 2015, Department of Physiology, NUS
  • 2015 Swee Liew-Wadsworth Intra-Department and Concept Grants, Department of Physiology, NUS
  • 2015 Swee Liew-Wadsworth Concept Grants 2015, Department of Physiology, NUS
  • 2015-present Distinguished Visiting Fellow, Curtin University, Perth, Australia
  • 2018 Swee Liew-Wadsworth Research Publication Award 2018 , Department of Physiology, NUS (Platinum and Silver)
  • June 2018 Board Member, International Cell Death Society (ICDS)
  • September 2018-present Visiting Professor, Sichuan University, Chengdu, China
  • 2019 Swee Liew-Wadsworth Research Publication Award 2019, Department of Physiology, NUS (Silver)
  • June-August 2019 Visiting Professor, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (host: Dr. Matthew Davids)
  • September 2019-present Guest Professor, University of Shenzhen, Shenzhen, China
  • September 2019-present Adjunct Professor, University of Paris Descartes, Paris, France
  • 2020 Swee Liew-Wadsworth Concept Grants 2020, Department of Physiology, NUS
  • 2020 Swee Liew-Wadsworth Research Publication Awards for 2020 (Silver)
  • 2020 Swee Liew-Wadsworth Research Publication Awards for 2020 (Gold)
  • 2020 NUS Medicine Fortitude Award 2020
  • 2021 Swee Liew-Wadsworth Concept Grants 2021, Department of Physiology, NUS
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