Herbert Schwarz

Herbert Schwarz

Ph.D.

Associate Professor, Deputy Head of Department

+65-6516-7773

phssh@nus.edu.sg

Immunotherapy

ORCID

Affiliations

  • Deputy Head, Department of Physiology, National University of Singapore
  • Associate Professor, Department of Physiology, National University of Singapore
  • Immunology Translational Research Programme, NUS Medicine

Research Areas of Interest:

  • Immune regulation
  • Costimulation
  • Tumor immunology
  • Immunotherapy
  • Autoimmunity

Selected Publications

  1. Wu Meihui, Hiu Yi Wong, Jia Le Lin, Annalena Ibanez Moliner and Herbert Schwarz. Induction of CD137 expression by viral genes reduces T cell costimulation. Journal of Cellular Physiology, 234(11):21076-21088, 2019.
  2. Rajendran Sakthi, Yating Li, Hiu Yi Wong, Cheng-I Wang and Herbert Schwarz. Development of a bispecific antibody targeting CD30 and CD137 on Hodgkin and Reed-Sternberg cells. Frontiers in Oncology, 9:945, 2019.
  3. Zeng Qun, Ye Mon Soe, Yanting Lim, Radoslaw Mikolaj Sobota and Herbert Schwarz. CD137 ligand interacts with CD32a to trigger reverse CD137 ligand signaling. Cellular & Molecular Immunology, 17(11):1188-1189, 2020.
  4. Wong Anna Hiu Yi, Ankshita Prasad, Shu Uin Gan, John Jia En Chua and Herbert Schwarz. Identification of CD137-expressing B Cells in Multiple Sclerosis which secrete IL-6 upon engagement by CD137 Ligand. Frontiers in Immunology, 11:571964, 2020.
  5. Luu Khang, Mugdha Vijay Patwardhan, Zeng Qun, Andreas Lundqvist, Stina Wickström, Herbert Schwarz. Regulatory T cells inhibit T cell activity by downregulating CD137L via CD137 transendocytosis. Cells, 10(2):353, 2021.
  6. Lee Kang Yi, Hiu Yi Wong, Qun Zeng, Man Si Cheng, Jia Le Lin, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh, Herbert Schwarz. Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting. OncoImmunology, 10(1):1877459, 2021.
  7. Prasad Mukul, Jia Le Lin, Gu Yue, Rashi Gupta, Paul Macary, Herbert Schwarz. No crossreactivity of anti-SARS-CoV-2 spike protein antibodies to Syncytin-1. Cellular & Molecular Immunology, Nov;18(11):2566-2568, 2021.
  8. Nickles Emily, Bhushan Dharmadhikari, Li Yating, …, Boon Cher Goh, Herbert Schwarz. Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit. Cancer Immunology, Immunotherapy, 71(6):1531-1543, 2022.
  9. Weigand Kilian, Georg Peschel, Jonathan Grimm, Khang Luu, Doris Schacherer, Martina Müller, Christa Buechler and Herbert Schwarz. Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol-associated disease etiology. European J. of Immunology, 52(4):633-645, 2022.
  10. Prasad Mukul, Sashigala Ponnalagu, Qun Zeng, Khang Luu, Si Min Lang, Hiu Yi Wong, Man Si Cheng, Meihui Wu, Karthik Mallilankaraman, Radoslaw Mikolaj Sobota, Yan Ting Lim, Loo Chien Wang, Chuan Keng Goh, Kai Xun Joshua Tay, Kwok Seng Loh, Cheng-I Wang, Wen-Hsien Lee, Boon Cher Goh, Chwee Ming Lim, Herbert Schwarz. Epstein-Barr Virus-Induced Ectopic CD137 Expression Helps Nasopharyngeal Carcinoma to Escape Immune Surveillance and Enables Targeting by Chimeric Antigen Receptors. Cancer Immunology, Immunotherapy, 71(11):2583-2596, 2022.

Awards

  • 1989–1991 Recipient of a NATO fellowship
  • 1995–1998 Habilitationsstipendium from the German Research Council
  • 1998 Recipient of the FLÜGGE Programme from the State of Bavaria
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