Wong Lik Wei

Wong Lik Wei

PhD

Instructor

+65-6516 3665 (Office);
+65-6516 5882 (Lab)

+65-6778 8161

phswlw@nus.edu.sg

ORCiD

Affiliations

  • Instructor, Department of Physiology, National University of Singapore

Research Areas of Interest:

  • The Science of Learning and Memory in Teaching and Education
  • The Influence of Sleep, Aging and Neurodegenerative Diseases on Learning and Memory

Selected Publications

  1. Zijun Wang, Brian K. Kennedy, Lik-Wei Wong* and Sreedharan Sajikumar*. 2023. Aging inverts the effects of p75NTR-modulated mTOR manipulation on hippocampal neuron synaptic plasticity. The FASEB Journal 37 (8), e23067.
    *Co-correspondence.
  2. Vijay R Varma, Rishi J Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B Horton, Seoyoung C Kim, Tobias Gerhard, Jodi B Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar and Madhav Thambisetty. 2022. Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease. Molecular psychiatry 28 (3), 1312-1326.
  3. Maria Vazquez Pavon, Sheeja Navakkode, Lik-Wei Wong and Sreedharan Sajikumar. 2022. Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer’s disease. Seminars in cell & developmental biology 139, 111-120.
  4. Chong, Yee Song, Lik-Wei Wong, Jessica Gaunt, Yan Jun Lee, Cai Shan Goh, Richard GM Morris, Toh Hean Ch’ng and Sreedharan Sajikumar. 2022. Distinct contributions of ventral CA1/amygdala co-activation to the induction and maintenance of synaptic plasticity. Cerebral Cortex 33 (3), 676-690.
  5. Lik-Wei Wong, Zijun Wang, Sheila Rui Xia Ang and Sreedharan Sajikumar. 2022. Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit? Ageing Research Reviews: 101567.
  6. Lik-Wei Wong, Yee Song Chong, Wei Lin, Lilian Kisiswa, Eunice Sim, Carlos F. Ibáñez and Sreedharan Sajikumar. 2021. Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. Aging Cell 20 (2), e13305.
  7. Chenju Yi, Ket Yin Goh, Lik‐Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar and Carlos F. Ibáñez. 2022. Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization. The EMBO journal 40 (2), e104450.
  8. Zhangsen Huang*, Lik-Wei Wong*, Yixun Su, Xiaomin Huang, Nan Wang, Hui Chen and Chenju Yi. 2000. Blood-brain barrier integrity in the pathogenesis of Alzheimer’s disease. Frontiers in Neuroendocrinology 59: 100857.
  9. Lik-Wei Wong, Yee Song Chong, Win Lee Edwin Wong and Sreedharan Sajikumar. 2020. Inhibition of histone deacetylase reinstates hippocampus dependent long-term synaptic plasticity and associative memory in sleep deprived mice. Cerebral Cortex 30(7): 4169–4182.
  10. Lik-Wei Wong, Jason Y Tann, Carlos F Ibáñez and Sreedharan Sajikumar. 2019. The p75 neurotrophin receptor is an essential mediator of impairments in hippocampal-dependent associative plasticity and memory induced by sleep deprivation. The Journal of Neuroscience 39(28): 5452-5465.
  11. Jason Y Tann, Lik-Wei Wong, Sreedharan Sajikumar and Carlos F Ibáñez. 2019. Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. EMBO Journal

Awards

  • 2020, 2022 Swee Liew-Wadsworth Research Publication Silver Award
  • 2020 NUS Medicine – Outstanding Mentor Award for Research Fellows
  • 2020 FENS-IBRO/PERC travel grant
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