Research Areas of Interest:

• Drug Testing Platforms
• Digital Liver Projects
• Micro-tissue Fabrication Factory

Selected Publications

• Gupta, K., Ng, I.C., Balachander, G.M., Nguyen, B.P., Tucker-Kellogg, L., Low, B.C., and Yu, H. (2020) Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials, November 2020; 259: 120283.
• Tasnim, F., Singh, N.H., Tan, E.K.F., Xing, J., Li, H., Hissette, S., Manesh, S., Fulwood, J., Gupta, K., Ng, C.W., Xu, S., Hill, J., and Yu, H. (2020) Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing. Scientific Reports, 16 Mar 2020; 10: 4768.
• Tasnim, F., Xing, J., Huang, X., Mo, S., Wei, X., Tan, M.-H. and Yu, H. (2019) Generation of Mature Kupffer Cells from Human Induced Pluripotent Stem Cells. Biomaterials, February 2019; 192: 337-391.
• Yu, Y., Wang, J., Ng, C.W., Ma, Y., Mo, S., Fong, L.S.E., Xing, J., Song, Z., Xie, Y., Si, K., Wee, A., Welsch, R.E., So, P.T.C., and Yu, H. (2018) Deep learning enhances automated scoring of liver fibrosis stages. Scientific Reports, 30 October 2018; 8: 16016.
• Li, Q., Zhang, Y., Pluchon, P., Robens, J., Herr, K., Mercade, M., Thiery, J.P., Yu, H.*, and Viasnoff, V. (2016) Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension. Nature Cell Biology, April 2016; 8: 311-318.