Academic Staff

Associate Professor
LIANG Fengyi

(PhD, MMed)

Tel: +65 6516 1936
Office: MD10 #04-01R

Research Interests
  • Glia neurobiology, especially oligodendroglia and myelination in relation to cytoskeleton-related oligodendroglial proteins.
  • Cell type-specific novel genes/proteins in the CNS.
  • Gene expression in relation to synaptic plasticity and neurological/psychiatric diseases.
  • The motor nervous system in relation to neural degeneration/regeneration.
Current Projects
  • Actin cytoskeleton and related proteins in myelination, neuron-glia interaction and neurodegenerative diseases.
  • Sirtuins in CNS development, ageing and diseases.
  • Synaptic proteins, synaptic plasticity and neurological/psychiatric diseases.
Selected Publications
  • Liang F (2017) Olfactory receptor neuronal dendrites become mostly intra-sustentacularly enwrapped upon maturity. J Anat, (in press).
  • Liang F, Hwang JH, Tang NW, Hunziker W. (2017) Juxtanodin in retinal pigment epithelial cells: expression and biological activities in regulating cell morphology and actin cytoskeleton organization. J Comp Neurol, DOI: 10.1002/cne.24301 (Epub ahead of print).
  • Liang F, Wang X, Ow SH, Chen W, Ong WC (2017) Sirtuin 5 is anti-apoptotic and anti-oxidative in cultured SH-EP neuroblastoma cells. Neurotox Res 31:63-76.
  • Sun J, Pan QC, Chew TW, Liang FY, Burmeister M, Low BC (2015) BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis. Dev Cell 34(5)555-568.
  • Liu R, Zhang S, Yang H, Ju P, Xia Y, Shi Y, Lim TH, Lim AS, Liang FY, Feng Z (2015) Characterization and therapeutic evaluation of a Nestin+ CNP+ NG2+ cell population on mouse spinal cord injury. Exp Neurol 269:28-42.
  • Qiu L, Yu H, Liang FY (2015) Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stress. J Neurochem 135:492-507.
  • Ardestani PM, Liang FY (2013) Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells. Nucleus 3(5):442-451.
  • Ruskamo S, Chukhlieb M, Vahokoski J, Bhargav SP, Liang FY, Kursula I, Kursula P (2012) Juxtanodin is an intrinsically disordered F-actin-binding protein. Sci Rep 2:899
  • Xia W, Liang F (2012) 4.1G promotes arborization and tight junction formation of oligodendrocyte cell line OLN-93. J Cell Physiol. 227(6):2730-2739
  • Kato T, Kasai A, Mizuno M, Liang F, Shintani N, Maeda S, Yokoyama M, Ozaki M, Nawa H (2010) Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1. PLoS ONE 5(12):e14185
  • Meng J, Xia W, Tang J, Tang BL, Liang F (2010) Dephosphorylation-dependent inhibitory activity of juxtanodin on filamentous actin disassembly. J Biol Chem 285(37):28838-28849
  • Ng EL, Ng JJ, Liang F, Tang BL. (2009) Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells. J Cell Physiol 221(3):716-28.
  • Tang J, Tang JH, Ling EA, Wu YJ, Liang F (2009) Juxtanodin in the rat olfactory epithelium: specific expression in sustentacular cells and preferential subcellular positioning at the apical junctional belt. Neuroscience 161:249-258
  • Liang F, Zhang B, Guo J, Tang J, Li W, Ling EA, Chu H, Wu Y, Cao Q (2007) RIM3γ is a postsynaptic protein in the rat CNS. J Comp Neurol. 503(4):501-510.
  • Li WB, Zhang B, TANG J, CAO Q, WU Y, Wu C, Guo J, Ling EA and Liang F (2007) Sirtuin 2, a mammalian homolog of yeast SIR2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin. J Neurosci 27(10):2606-2616.
  • Buschdorf JP, CHEW LL, Zhang B, CAO Q, Liang F, Liou YC, Zhou Y and Low BC (2006) Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. J Cell Sci, 119(16):3337-3350.
  • Zhang B, Cao Q, Guo A, Chu H, Chan YG, Buschdorf JP, Low BC, Ling EA, Liang F (2005) Juxtanodin: An oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking. Proc Natl Acad Sci USA 102:11527-11532.
  • Yap CC, Liang F, Yamazaki Y, Muto Y, Kishida H, Hayashida T, Hashikawa T & Yano R (2003) CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase. J Neurochem 85: 123-134.
  • Jia Q, Liang F, Ohka S, Nomoto A, & Hashikawa T (2002) Expression of brain-derived neurotrophic factor in the central nervous system of mice using a poliovirus-based vector. J.Neurovirol. 8:14-23.
  • Tochitani S, Liang F, Watakabe A, Hashikawa T & Yamamori T (2001) The occ1 gene is preferentially expressed in the primary visual cortex in an activity-dependent manner: a pattern of gene expression related to the cytoarchitectonic area in adult macaque neocortex. Eur J Neurosci 13(2):297-307.
  • Liang F , Hatanaka Y, Saito H, Yamamori T & Hashikawa T (2000) Differential expression of gamma-aminobutyric acid type B receptor-1a and 1b mRNA variants in GABA and non-GABAergic neurons of the rat brain. J Comp Neurol 416:475-495.
  • Liang F , Le LD & Jones EG (1998) Reciprocal up- and down-regulation of BDNF mRNA in a tetanus toxin-induced epileptic focus and inhibitory surround in cerebral cortex. Cereb Cort 8(6):481-491.
  • Rouiller EM, Yu XH, Moret V, Tempini A, Wiesendanger M & Liang F (1998) Dexterity in adult monkeys following early lesion of the motor cortical hand area: the role of cortex adjacent to the lesion. Eur J Neurosci, 10(2):729-740.
  • Liang F & Jones EG (1997) Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy. J Neurosci, 17(6):2168 -2180.
  • Liang F & Jones EG (1997) Zif268 and Fos-like immunoreactivity in tetanus toxin-induced epilepsy: reciprocal changes in the epileptic focus and the surround. Brain Res, 778(2):281-292.
  • Liang F, Jones EG (1996) Peripheral nerve stimulation increases Fos immunoreactivity without affecting type II Ca2+/calmodulin-dependent protein kinase, glutamic acid decarboxylase, or GABAA receptor gene expression in cat spinal cord. Exp Brain Res 111:326-336.
  • Liang F, Isackson PJ, Jones EG (1996) Stimulus-dependent, reciprocal up- and downregulation of glutamic acid decarboxylase and CaM kinase II gene expression in rat cerebral cortex. Exp Brain Res 110:163-174.
  • Liang F & Jones EG (1996) Developmental and stimulus-specific expression of the immediate-early gene zif268 in rat spinal cord. Brain Res, 729:246-252.
Honours & Awards
  • Honorary treasurer, Singapore Neuroscience Association (SNA) (2011- 2013)
  • Foreign Member, Society for Neuroscience.
  • Member, International Brain Research Organization (IBRO).