Academic Staff

Associate Professor

Dinesh Kumar, Srinivasan

(PhD; MS; MBBS)


Tel: +65 6601 5996
Email: dineshkumar@nus.edu.sg
Office: MD10 #04-01Q


Research Interests
  • Diabetes induced congenital heart defects
Current Projects
  • Tissue engineering
  • Medical education
Areas of Collaborative Research
  • Ageing
  • Traumatic brain injury
Selected Publications
  • Tham AY, Gandhimathi C, Praveena J, Venugopal JR, Ramakrishna S, Kumar SD. (2016). Minocycline loaded hybrid composites nanoparticles for osteogenic differentiation of mesenchymal stem cells to bone tissue engineering. International Journal of Molecular Sciences, 17(8), 1222.
  • Suriyanto, Ng EY, Say XJ, Ng CE, Yan XS, Kumar SD. (2016). Quantitative means for differentiating renal obstruction by analysing renography by compartmental modelling of renal fluid flow rate. Nuclear Medicine Communications, 37(9), 904-910.
  • Jayaraman P, Gandhimathi C, Venugopal JR, Ramakrishna S, Kumar SD. (2016). Minocycline hydrochloride entrapped biomimetic nanofibrous substitutes for adipose derived stem cells differentiation into osteogenesis. Regenerative Engineering and Translational Medicine, 2 (1), 10–22.
  • Jayaraman P, Gandhimathi C, Venugopal JR, Becker DL, Ramakrishna S, Kumar SD. (2015). Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering. Advanced Drug Delivery Reviews, 94, 77-95.
  • Canchi T, Kumar SD, Ng EY, Narayanan S. (2015). A review of computational methods to predict the risk of rupture of abdominal aortic aneurysms. Biomed Research International, 861627.
  • Arrojo e Drigo R, Ali Y, Diez J, Kumar SD, Berggren PO, Boehm BO. (2015). New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. Diabetologia, 58(10), 2218-28.
  • Gandhimathi G, Venugopal JR, Sundarrajan S, Sridhar R, Tay SSW, Ramakrishna S, Kumar SD. (2015). Breathable medicine: Pulmonary mode of drug delivery. Journal of Nanoscience and Nanotechnology, 15(4), 2591-2604.
  • Gandhimathi C, Venugopal JR, Tham YA, Ramakrishna S, Kumar SD. (2015). Biomimetic hybrid nanofibrous substrates for mesenchymal stem cells differentiation into osteogenic cells. Materials Science and Engineering C: Materials for Biological Applications, 49, 776-85.
  • Gandhimathi C, Neo XH, Praveena J, Venugopal JR, Ramakrishna S, Kumar SD. (2015). Controlled release of dexamethasone in PCL/silk fibroin/ascorbic acid nanoparticles for the initiation of adipose derived stem cells into osteogenesis. Journal of Drug Metabolism & Toxicology, 5:177.
  • Gandhimathi C, Venugopal JR, Bhaarathy V, Ramakrishna S, Kumar SD. (2014). Biocomposite nanofibrous strategies for the controlled release of biomolecules for skin tissue regeneration. International Journal of Nanomedicine, 9, 4709-22.
  • Peh MT, Anwar AB, Ng DS, Atan MS, Kumar SD, Moore PK. (2014). Effect of feeding a high fat diet on hydrogen sulfide (H2S) metabolism in the mouse. Nitric Oxide: Biology and Chemistry, 41, 138-45.
  • Qabazard B, Li L, Gruber J, Peh MT, Ng LF, Kumar SD, Rose P, Tan CH, Dymock BW, Wei F, Swain SC, Halliwell B, Stürzenbaum SR, Moore PK. (2014). Hydrogen sulfide is an endogenous regulator of ageing in Caenorhabditis elegans. Antioxidants & Redox Signaling, 20(16), 2621-30.
  • Sukanya S, Jadhav SP, Tay SSW, Bay BH, Kumar SD, Danny R, Dheen ST. (2013). Analysis of epigenetic factors in mouse embryonic neural stem cells exposed to hyperglycemia. PLoS ONE, 8(6), e65945.
  • Basu S*, Kumar SD*, Yang K, Raina H, Banerjee S, Zhang R, Fisher SA, Proweller A. (2013). Notch transcriptional control of vascular smooth muscle regulatory gene expression and function. Journal of Biological Chemistry, 288 (16), 11191-202. *Equal authorship.
  • Vijaya M, Manikandan J, Parakalan R, Dheen ST, Kumar SD*, Tay SS. (2013). Differential gene expression profiles during embryonic heart development in diabetic mice pregnancy. Gene, 516(2), 218-27. * Corresponding author.
  • Kumar SD*, Vijaya M, Samy RP, Dheen ST, Ren M, Watt F, Kang YJ, Bay BH, Tay SS. (2012). Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice. Free Radical Biology and Medicine, 53(8), 1595-606. * Corresponding author.
  • Lu J, Ng KC, Ling G, Wu J, Poon DJ, Kan EM, Tan MH, Wu YJ, Li P, Moochhala S, Yap E, Lee LK, Teo M, Yeh IB, Sergio DM, Chua F, Kumar SD, Ling EA. (2012). Effect of blast exposure on the brain structure and cognition in Macaca fascicularis. Journal of Neurotrauma, 29(7), 1434-54.
  • Cui Y*, Wang W*, Dong N*, Lou J*, Kumar SD, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q. (2012). Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature, 484(7393), 246-50. *Equal authorship.
  • Li T, Jan M, Kumar SD and Low AF. (2012). Development of piezoelectric ultrasonic thrombolysis device for blood clot emulsification. ISRN Materials Science, 2012(106484), 6 pages.
  • Loh WT, Dheen ST, Jiang B, Kumar SD, Tay SS. (2011). Molecular and morphological characterization of neural tube defects in embryos of diabetic Swiss Albino mice. Histology and Histopathology, 26(8), 965-78.
  • Gouk SS, Loh YF, Kumar SD, Watson PF, Kuleshova LL. (2011). Cryopreservation of mouse testicular tissue: prospect for harvesting spermatogonial stem cells for fertility preservation. Fertility and Sterility, 95(7), 2399-403.
  • Kumar SD, Krishnamurthy K, Manikandan J, Pakeerappa PN, Pushparaj PN. (2011). Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation. Bioinformation, 22:6(3), 111-4.
  • Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, Dheen ST. (2010). Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience, 166(1), 132-44.
  • Shoba B, Lwin ZM, Ling LS, Bay BH, Yip GW, Kumar SD. (2009). Function of sirtuins in biological tissues. The Anatomical Record, 292(4), 536-43.
  • Tay WL, Yip GW, Tan PH, Matsumoto K, Yeo R, Ng TP, Kumar SD, Tsujimoto M, Bay BH. (2009). Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer. Modern Pathology, 22(2), 282-90.
  • Dheen ST, Tay SS, Boran J, Ting LW, Kumar SD, Fu J, Ling EA. (2009). Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Current Medicinal Chemistry, 16(18), 2345-54.
  • Jiang B, Kumar SD, Loh WT, Manikandan J, Ling EA, Tay SS, Dheen ST. (2008). Global gene expression analysis of cranial neural tubes in embryos of diabetic mice. Journal of Neuroscience Research, 86(16), 3481-93.
  • Pushparaj PN, Aarthi JJ, Manikandan J, Kumar SD. (2008). siRNA, miRNA, and shRNA: in vivo applications. Journal of Dental Research, 87(11), 992-1003.
  • Kumar SD, Yong SK, Dheen ST, Bay BH, Tay SS. (2008). Cardiac malformations are associated with altered expression of vascular endothelial growth factor and endothelial nitric oxide synthase genes in embryos of diabetic mice. Experimental Biology and Medicine, 233(11), 1421-32.
  • Manikandan J, Aarthi JJ, Kumar SD, Pushparaj PN. (2008). Oncomirs: the potential role of non-coding microRNAs in understanding cancer. Bioinformation, 20;2(8), 330-4.
  • Soo ET, Yip GW, Lwin ZM, Kumar SD, Bay BH. (2008). Heat shock proteins as novel therapeutic targets in cancer. In Vivo, 22(3), 311-5.
  • Pushparaj PN, Aarthi JJ, Kumar SD, Manikandan J. (2008). RNAi and RNAa-the yin and yang of RNAome. Bioinformation, 2(6), 235-7.
  • Kumar SD, Dheen ST, Tay SS. (2007). Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development. Cardiovascular Diabetology, 6, 34.
  • Kumar SD*, Tay SS, Ling EA. (2006). Partial urethral obstruction enhances NADPH-diaphorase activity in the monkey (Macaca fascicularis) bladder: light and electron microscopic studies. Histology and Histopathology, 21(4), 383-91. * Corresponding author.
  • Ji JF, Dheen ST, Kumar SD, He BP, Tay SS. (2005). Expressions of cytokines and chemokines in the dorsal motor nucleus of the vagus nerve after right vagotomy. Brain research, 142(1), 47-57.
  • Kumar SD, Tay SS. (2000). Changes in peptidergic nerves in the atrioventricular valves of streptozotocin-induced diabetic rats: a confocal microscopy study. The Anatomical Record, 258(3), 277-85.
  • Kumar SD, Tay SS. (1999). Ultrastructural changes in the atrioventricular valves of streptozotocin-induced diabetic rats. Journal fuer Hirnforschung, 39(4), 559-66.
Honours & Awards
  • Long Service Award for Service to Education, MOE, Singapore, 2015
  • SHBC Best Poster Award, Health Professions Education, Singapore, 2014
  • Singapore Young Investigator Award, Basic Science/ Translational Research, Singapore, 2014
  • Favorite Faculty, LKCMedicine, NTU, 2014
  • Reviewer Recognition Award, Singapore Medical Journal, 2012            
  • Pewter Award for Service to Education, MOE, Singapore, 2011
  • Fellowship, Case Western Reserve University, Cleveland, OH, USA, 2010/2011
  • Fellowship, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA, 2009/2010
  • AAA Postdoctoral Travel Scholarship, New Orleans, USA, 2009
  • Finalist, AAA Postdoctoral Poster Award, EB2009, USA, 2009
  • Appreciation Letter for Revised Phase 1 Curriculum, Dean, YLLSoM, NUS, 2008
  • Appreciation Letter for Mentorship Program, Vice-Dean (Education), YLLSoM, NUS, 2006
  • Scholarship, Kazato Research Foundation and 8APEM, Japan, 2004
  • Appreciation Letter for Patient Satisfaction and Service Excellence, CEO, NUH, 2002
  • Travel Scholarships, Microscopy Society (Singapore), 1998 and 2000
  • Graduate Research Scholarship, YLLSoM, NUS, 1998-2000
  • Undergraduate Merit Scholarship, RYA, Chennai, India, 1989-1994
Other Appointments
  • Integration Lead Educator (ILE), YLLSoM, NUS
  • Member, Phase I Committee, YLLSoM, NUS
  • Member, Phase I Curriculum and Assessment Committee, YLLSoM, NUS
  • Member, Phase I System Based Workgroup (SBW) Committee, YLLSoM, NUS
  • Member, Phases I & II Collaborative Learning Cases (CLC) Committee, YLLSoM, NUS
  • Vice-Chairperson, Lianhua Primary School Advisory Committee, Ministry of Education (MOE), Singapore
  • Visiting Professor, Sree Balaji Medical College and Hospital, Bharath University, India
  • Associate Editor, Journal of Medical Imaging and Health Informatics
  • Editorial Board Member, Annals of Clinical Cytology and Histology
  • Editorial Board Member, Journal of Cytology and Tissue Biology
  • Editorial Board Member, Journal of Krishna Institute of Medical Sciences University
Career History
  • Lead for Anatomy, Co-Lead for Human Structure & Function, LKCMedicine, NTU, Singapore (2012–2016)
  • Assistant Professor, LKCMedicine, NTU, Singapore (2012–2016)
  • Assistant Dean, Exams and Assessments (Phase 1), LKCMedicine, NTU, Singapore (2012–2014)
  • Faculty-in-Residence, LKCMedicine, NTU, Singapore (2012–2016)     
  • Senior Lecturer, Anatomy, National University of Singapore (2011-2011)
  • Staff, Case Western Reserve University, Cleveland, OH, USA (2010–2011)
  • Fellow, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA (2009–2010)
  • Lecturer, Anatomy, National University of Singapore (2008–2009) 
  • Teaching Assistant, Anatomy, National University of Singapore (2003–2008)
  • Clinical Fellow, CTVS, National University Hospitals Singapore (2001–2002)   
  • Research Assistant, Surgery, National University of Singapore (2000–2001)
  • Research Scholar, Anatomy, National University Singapore (1998–2000)
  • Medical Officer, St Isabel’s Hospital, Chennai, India (1997–1997)
  • House Officer, Government Stanley Hospitals, Chennai, India (1996–1996)
Professional Organizations
  • Member, American Association of Anatomists, USA
  • Member, Microscopy Society (Singapore)
  • Member, Singapore Neuroscience Association, Singapore