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Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression

28 December 2023

Intestinal metaplasia (IM), often symptomless, poses a six-fold increased risk of stomach cancer. In this cross-institut...

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Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma

28 November 2023

Multiple myeloma cells adapt to the harsh bone marrow environment by changing their metabolism. This change affects how ...

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Alterations to DNA methylation patterns induced by chemotherapy treatment are associated with negative impacts on the olfactory pathway

27 November 2023

Exposure to chemotherapy can change “chemical tags” in our DNA. These tags don’t change the actual DN...

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Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

22 November 2023

A team of scientists, led by N2CR member Dr. Tee Wee Wei, has identified the enzyme DNA topoisomerase I (TOP1) as a key ...

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N2CR Functional Precision Medicine Asia Symposium 2023

20 November 2023

On 14 November 2023, N2CR hosted the N2CR Functional Precision Medicine Asia Symposium 2023 at the MD 11 CRC Auditorium....

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CanCycle 2023 2nd Edition Launch at PAssion Wave East Coast

20 November 2023

Are you ready to CanCycle?! CanCycle 2023 is back for its second iteration. Thank you to all who attended the launch at ...

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Research News

TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia

11 October 2023

This study, co-led by A/Prof Takaomi Sanda and A/Prof Allen Yeoh, delves into T-cell acute lymphoblastic leukemia (T-ALL...

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PI3K/AKT/mTOR signalling transduction pathway and targeted therapies in cancer

11 October 2023

The PI3K/AKT/mTOR (PAM) signaling pathway is crucial in regulating cell survival, growth, and the cell cycle. Its comple...

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N2CR Invited Speaker Series with Dr Sophia Adamia

12 September 2023

N2CR had the honour of having Dr Sophia Adamia, from the Beth Israel Deaconess Medical Center in Boston, visit us on 5 S...

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