Abstract:
Innate immune cells such as macrophages and neutrophils express a repertoire of pattern recognition receptors to sense and detect microbial pathogens, however, pathogenic microorganisms have developed strategies to overcome innate immunity, often by injecting effectors that block innate immune signalling. Our lab is interested in understanding the molecular mechanisms by which myeloid cells overcome such microbial blockade to mount an effective immune response. Here, I will discuss our published and unpublished work on how different cell death modalities – apoptosis, pyroptosis and necroptosis is activated during microbial infection and how pathogens subvert these host responses.
Biography
Kaiwen is an Assistant Professor at the Department of Microbiology and Immunology and is affiliated with the Immunology TRP. Kaiwen completed his PhD in University of Queensland in 2015. With the support of a Marie Curie fellowship, Kaiwen relocated to University of Lausanne, Switzerland, for his postdoctoral fellowship. He joined NUS in late 2020.
