Introduction of
Who we are
The Immunology Translational Research Programme aims to understand the role of the immune system in health and diseases and its regulation with the goal of enabling discovery and development of more effective immunotherapy, new treatment guidelines and diagnostic tests for patients with disease-specific problems such as autoimmune and airway diseases, cancer, chronic inflammation, infections and organ / tissue transplantation.
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Qu Biologics’ Site Specific Immunomodulator Enables CAR T-cell Cancer Efficacy in Solid Tumor
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Soaring Beyond the Bounds of Her Illness
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Zero-G Wells: Taking mechanobiology into space
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NUS researchers improve CAR-T cell therapy for solid tumours through inhibition of conventional signalling pathway
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NUS Medicine and CNA developed documentaries about the School’s Translational Research Programmes
Seminar
Intron Retention of DDX39A is a sensor for Myc/Spliceosome program in hepatocellular carcinoma
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NUS Yong Loo Lin School of Medicine Immunology TRP Research Seminar
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NUS Yong Loo Lin School of Medicine Immunology TRP Research Seminar
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NUS Yong Loo Lin School of Medicine Immunology TRP Research Seminar
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NUS Yong Loo Lin School of Medicine Immunology TRP Research Seminar
Publications
DUSP6 regulates Notch1 signalling in colorectal cancer
Publications
MFSD7c functions as a transporter of choline at the blood–brain barrier
Publications
Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis
Publications
IL12/18/21 Preactivation Enhances the Antitumor Efficacy of Expanded γδT Cells and Overcomes Resistance to Anti–PD-L1 Treatment
Publications
Combining Multimodal Magnetic Resonance Brain Imaging and Machine Learning to Unravel Neurocognitive Function in Non-Neuropsychiatric Systemic Lupus Erythematosus
The hallmark of
the programme
Research Team of
Immune Homeostasis
To advance understanding the role of the immune
system in health and diseases and its regulation.
A/Prof Zhang Yongliang
Coordinator
Key Areas of Research
- Immune response to infection and cancer
- Signal transduction in cancer development
- Dual-specificity phosphatases (DUSPs)
Dr Chen Kaiwen
Coordinator
Key Areas of Research
- Innate immunity and inflammation
- Programmed cell death
- Host-pathogen interactions
Research Team of
Immunotherapies
To advance understanding the role of the immune
system in health and diseases and its regulation.
A/Prof Liu Haiyan
Coordinator
Key Areas of Research
- Adoptive immunotherapy
- Cancer vaccines
- Tumor microenvironment
- Innate immune cell subsets, including ILCs, NK cells and γδT cells
Prof Nicholas Gascoigne
Coordinator
Key Areas of Research
- CAR-T cells
- T cell activation and signalling
- T cell development
- Microbiome effect on T cell differentiation
Research Team of
The Asian Immunophenotype
and Clinical Investigations
To advance understanding the role of the immune
system in health and diseases and its regulation.
Dr Tay Sen Hee Frank
Coordinator
Key Areas of Research
- Systemic lupus erythematosus
- Nonsteroidal anti-inflammatory drug hypersensitivity
- Immune-related adverse effects
- Neutrophils
- Epigenetics
Dr Makoto Yawata
Coordinator
Key Areas of Research
- Immunological mechanisms of NK cell responses in cancer and infectious diseases
- Computational characterization of genetic and functional diversification in human NK cell repertoires
- Phenotypes and functions of organ-specific NK cells in health and disease
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