Introduction of
Who we are
The Immunology Translational Research Programme aims to understand the role of the immune system in health and diseases and its regulation with the goal of enabling discovery and development of more effective immunotherapy, new treatment guidelines and diagnostic tests for patients with disease-specific problems such as autoimmune and airway diseases, cancer, chronic inflammation, infections and organ / tissue transplantation.
Director’s Message
The Immunology Translational Research Programme (ITRP) is founded on two core principles that drive our research and training mission:
First, a deep understanding of immune mechanisms forms the foundation for diagnosing, treating, and ultimately preventing human diseases. Second, the most impactful scientific advances arise when a diverse team of scientists and clinicians—each bringing complementary expertise—collaborates in an interactive, and supportive environment.
Our People
Get to know our team players who diligently contributed to the research programme
A/Prof Zhang Yongliang
Micro/Immuno
Key Areas of Research
- Immune response to infection and cancer
- Signal transduction in cancer development
- Dual-specificity phosphatases (DUSPs)
Dr Tay Sen Hee Frank
Medicine
Key Areas of Research
- Systemic lupus erythematosus
- Nonsteroidal anti-inflammatory drug hypersensitivity
- Immune-related adverse effects
- Neutrophils
- Epigenetics
Dr Peh Hong Yong
Pharmacology
Key Areas of Research
- Resolution of inflammation
- Pro-resolving lipid mediators (lipoxins, resolvins, maresins, protectins) and eicosanoids
- Inflammation and inflammaging
- Macrophage efferocytosis
A/Prof Paul MacAry
Micro/Immuno
Key Areas of Research
- Human Antibody Discovery and Engineering
- Alloantibody
- Dengue Virus Antibodies
A/Prof Nguyen Nam Long
Biochemistry
Key Areas of Research
- Sphingosine-1-phosphate transport and signaling
- Nutrient transport at blood-brain barrier
- Lysosomal transport pathways for small molecules
- Lysolipid transport and functions
A/Prof Lu Jinhua
Micro/Immuno
Key Areas of Research
- Cancer vaccines: antigens & adjuvants
- Systemic lupus erythematosus (SLE): alarmins & autoantibodies
- Complement: C1q & C1 proteases
A/Prof Lina Lim Hsiu Kim
Physiology
Key Areas of Research
- Annexin-A1
- Macrophages and Dendritic cells in the Tumor microenvironment
- Impact of Stress on cancer and inflammation
A/Prof Herbert Schwarz
Physiology
Key Areas of Research
- Tumour Immunology
- Cancer vaccines
- Dendritic Cells
- CD137 – CD137 ligand
Dr Chen Kaiwen
Micro/Immuno
Key Areas of Research
- Innate immunity and inflammation
- Programmed cell death
- Host-pathogen interactions
A/Prof Chen Jinmiao
Micro/Immuno
Key Areas of Research
- Single-cell omics, Spatial omics, AI, Immunology.
- Developing novel analytical methods and databases for the integration and analyses of single-cell and spatial omics data.
Dr Benoit Malleret
Micro/Immuno
Key Areas of Research
- Human and zoonotic malaria
- Gut microbiome dysbiosis
- Electron microscopy
Dr Anne Beghin
Micro/Immuno
Key Areas of Research
- Mechanobiology, cancer and immunology research
- Organoids, Organ-on-chip, 3D bioprinter
- Microscopy, AI, image analysis
- Microgravity and Space environnements (regolith, radiation, microgravity) effect on human tissue homeostasis
Research Team of
Immune Homeostasis
To advance understanding the role of the immune
system in health and diseases and its regulation.
Serene Tan
Admin Lead
Ms Too Chien Tei
Senior Laboratory Manager
Research Team of
Immunotherapies
To advance understanding the role of the immune
system in health and diseases and its regulation.
Serene Tan
Admin Lead
Ms Too Chien Tei
Senior Laboratory Manager
Research Team of
The Asian Immunophenotype
and Clinical Investigations
To advance understanding the role of the immune
system in health and diseases and its regulation.
Serene Tan
Admin Lead
Ms Too Chien Tei
Senior Laboratory Manager
Providing Quality
Core Facilities
Equipped with cutting edge tools at the forefront of technology
Explore Our Trending
News & Events
Publications
Digitalized organoids: integrated pipelinefor high-speed 3D analysis of organoidstructures using multilevel segmentationand cellular topology
Publications
Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome
Publications
Nation-wide surveillance of tick (Acari: Ixodidae) infestations of humans in Singapore
Publications
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
Publications
DUSP6 regulates Notch1 signalling in colorectal cancer
Media
Farewell to A/Prof. Veronique Angeli
Media
SingHealth Duke-NUS Academic Medical Centre leads S$10m national effort to tackle muscle-loss in ageing Singapore
Media
Ticking time bomb? Study on ticks in Singapore calls for greater vigilance
Media
Happy CNY 2025. Thank you everyone for helping with the hampers.
Media
Singleron Seminar (Organized by ITRP Single Cell Genomics Core & Singleron)
Seminar
Tumor necrosis factor in host defense and barrier integrity
Seminar
The cGAMP transporter LRRC8VRAC and the noncanonical STING signaling in antiviral and antitumor immunity
Seminar
Ubiquitination in Cell Death and Tissue Injury
NUSMED ITRP Seminar Series
Basic Research and Translational Medicine in Lupus
Seminar
Intron Retention of DDX39A is a sensor for Myc/Spliceosome program in hepatocellular carcinoma
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