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introduction
who we are
The Cardiovascular-Metabolic Disease Translational Research Programme (CVMD-TRP), NUS Yong Loo Lin school of Medicine is dedicated to advancing the understanding of cardiovascular metabolic diseases and developing innovative therapies that can make a real difference in the lives of patients. We are mobilising our collective talent and resources for comprehensive research – encompassing molecules, DNA, RNA, cells, clinical trials, computational and data science, implementation, behavioural and social science.
primary objective
Tackling heart disease comprehensively
- Stem Cells
- CV Immunology
- Genomics
- Smooth Muscle Cells
- Pre-clinical Models
- Mitochondria
- CRISPR Gene Editing
- Clinical Trials
- Implementation & Behavioural Science
- Digital Health
coreS & capabilities
dedicated to our research, collaboration & innovation
Hyungwon Choi
CVMD TRP Director
Associate Professor
Key Areas of Research
- Systems Biology Approaches for Cellular Metabolism
- Cheminformatic Method Development
- High-Dimensional Statistical Computing for Network Biology
- Clinical Application of Mass Spectrometry-based Metabolomics and Proteomics
Mark Chan
CVMD TRP Deputy Director
Associate Professor
Key Areas of Research
- Cardiovascular Drug Discovery in Atherosclerosis & Myocardial Infarction
- Biomarker Discovery in Chronic & Acute Coronary Syndrome
- Outcomes & Systems of Care in Acute Coronary Syndrome
Koh Cho Yeow
CVMD TRP Research Director
Research Assistant Professor
Key Areas of Research
- Structure-function Relationship Studies
- Drug / Target / Probe Discovery
- Venom / Salivary Proteins & Peptides
Arthur Mark Richards
Visiting Professor
Key Areas of Research
- Neurohormonal physiology and pathophysiology in cardiovascular health and disease
- Heart Failure
- Acute coronary syndromes
- Hypertension
- Vasoactive hormones
- The Cardiac Natriuretic Peptides
Vitaly A. Sorokin
Assistant Professor
Key Areas of Research
- Vascular Smooth Muscle Cells
- Cardiovascular Single Cell Analysis
Chester Drum
Associate Professor
Key Areas of Research
- Mass spectrometry for precision medicine applications
- Biomarker discovery and multi-omic analyses of large patient cohorts
- Protein engineering using nano-scale exoshells
Roger Foo
Zayed bin Sultan Al Nahyan Professor of Medicine
Key Areas of Research
- Clinical Genomics
- Chromatin Architecture
- Cardiovascular Epigenetics & Cell States
- Long Non-coding RNA
- Clinical Genomics
Shu Ye
Professor
Key Areas of Research
- Genetic basis & mechanisms of cardiovascular diseases
- Pathogenesis of atherosclerosis
- Identification of therapeutic targets
Chen Ching Kit
Assistant Professor
Key Areas of Research
- Epigenetics in congenital heart disease
- Preclinical models of congenital heart disease
- Assessment of fetal cardiac function
- Infant heart transplantation
- Myocardial fibrosis & magnetic resonance mapping
Heng Chew Kiat
Research Associate Professor
Key Areas of Research
- Genetic epidemiology of cardiovascular diseases
- Functional characterization of novel proteins identified from genome wide association studies (GWAS) of coronary artery disease
Matthew Ackers-Johnson
Research Assistant Professor
Key Areas of Research
- Tissue & hPSC derived cell models
- Cell-cell communication
- Single cell sequencing
Reshma Taneja
Professor
Key Areas of Research
- Epigenetic regulation of skeletal muscle differentiation & regeneration
- Chromatin signalling networks in myopathies
Koh Cho Yeow
CVMD TRP Research Director
Research Assistant Professor
Key Areas of Research
- Structure-function Relationship Studies
- Drug / Target / Probe Discovery
- Venom / Salivary Proteins & Peptides
Shu Ye
Professor
Key Areas of Research
- Genetic basis & mechanisms of cardiovascular diseases
- Pathogenesis of atherosclerosis
- Identification of therapeutic targets
Vitaly A. Sorokin
Assistant Professor
Key Areas of Research
- Vascular Smooth Muscle Cells
- Cardiovascular Single Cell Analysis
Matthew Ackers-Johnson
Research Assistant Professor
Key Areas of Research
- Tissue & hPSC derived cell models
- Cell-cell communication
- Single cell sequencing
Roshni Rebecca Singaraja
Research Assistant Professor
Key Areas of Research
- Cardiovascular & metabolic diseases
- Target identification (human genetics) & validation
Veronique Angeli
Associate Professor
Key Areas of Research
- Lymphatic vessels & LYVE+ macrophage biology & function in resolution of inflammation & cardiovascular disease
Wang Wenru
Professor
Key Areas of Research
- Chronic illness and Long-Term Care
- Cardiovascular Health & Cardiac Rehabilitation
- Diabetes Management
- Active Aging
- mHealth
- Tele-medicine
- AI
Philipp Kaldis
Visiting Professor
Key Areas of Research
- Metabolic remodeling in liver diseases
- Obesity-induced liver cancer (HCC)
- Multi-omics analyses of human diseases and interorgan cross-talk
- Cell cycle regulation
Dan Yock Young
Associate Professor
Key Areas of Research
- Fatty liver disease
- Hepatology
Mark Dhinesh Muthiah
Associate Professor
Key Areas of Research
- Fatty liver disease
- Hepatology
Mayank Dalakoti
Associate Consultant Cardiologist (NUHS NCSP2.0 Awardee)
Mark Chan
CVMD TRP Deputy Director
Associate Professor
Key Areas of Research
- Cardiovascular Drug Discovery in Atherosclerosis & Myocardial Infarction
- Biomarker Discovery in Chronic & Acute Coronary Syndrome
- Outcomes & Systems of Care in Acute Coronary Syndrome
Koh Cho Yeow
CVMD TRP Research Director
Research Assistant Professor
Key Areas of Research
- Structure-function Relationship Studies
- Drug / Target / Probe Discovery
- Venom / Salivary Proteins & Peptides
Sia Ching Hui
Associate Consultant Cardiologist
Senior Lecturer (Nusmed Junior Academic Fellow)
Ronald Lee Chi Hang
Professor
Key Areas of Research
- Relationship between obstructive sleep apnea and cardiovascular disease
- Obstructive sleep apnea therapeutics on cardiovascular outcomes
- Use of Artificial Intelligence in the diagnosis of obstructive sleep apnea
- Epidemiology of obstructive sleep apnea in Asia
Mark Chan
CVMD TRP Deputy Director
Associate Professor
Key Areas of Research
- Cardiovascular Drug Discovery in Atherosclerosis & Myocardial Infarction
- Biomarker Discovery in Chronic & Acute Coronary Syndrome
- Outcomes & Systems of Care in Acute Coronary Syndrome
Christopher Chen
Associate Professor
Key Areas of Research
- Cognitive Impairment
- Dementia
- Cerebrovascular Disease
- Neurodegenerative Disease
- Translational research & Clinical trials in Stroke & Dementia
Theodoros Kofidis
Visiting Professor
Key Areas of Research
- MedTech & Innovation
Chester Drum
Associate Professor
Key Areas of Research
- Mass spectrometry for precision medicine applications
- Biomarker discovery and multi-omic analyses of large patient cohorts
- Protein engineering using nano-scale exoshells
Hyungwon Choi
CVMD TRP Director
Associate Professor
Key Areas of Research
- Systems Biology Approaches for Cellular Metabolism
- Cheminformatic Method Development
- High-Dimensional Statistical Computing for Network Biology
- Clinical Application of Mass Spectrometry-based Metabolomics and Proteomics
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