Publications
1. Yee YH, Chong SJF, Kong LR, Goh BC, Pervaiz S. Sustained IKKβ Phosphorylation and NF-κB Activation by Superoxide-induced Peroxynitrite-mediated Nitrotyrosine Modification of B56γ3 and PP2A Inactivation. Redox Biology 2021. DOI: 10.1016/j.redox.2020.101834
2. Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, Valentin R, Herbaux C, Collins M, Low ICC, Loh T, Davids M, Pervaiz S. Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism. Nucleic Acids Research. 2020 Dec 16;48(22):12727-12745. doi: 10.1093/nar/gkaa1110
3. Wang B, Bellot GL, Iskandar K, Chong TW, Goh FY, Tai JJ, Schwarz H, Wong SC, Pervaiz S. Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis. Sci Rep. 2020 Nov 2;10(1):18837. doi: 10.1038/s41598-020-74578-9.
4. Zheng B, Qu J, Ohuchida K, Feng H, Chong SJF, Yan Z, Piao Y, Liu P, Sheng N, Eguchi D, Ohtsuka T, Mizumoto K, Liu Z, Pervaiz S, Gong P, Nakamura M. LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer. Theranostics. 2020 Aug 13;10(22):10274-10289. doi: 10.7150/thno.47001.
5. Raman D, Chong SJF, Iskandar K, Hirpara JL, Pervaiz S. Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc. Redox Biol. 2020 Jul;34:101587. doi: 10.1016/j.redox.2020.101587
6. Pervaiz S, Bellot GL, Lemoine A, Brenner C. Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020;352:189-214. doi: 10.1016/bs.ircmb.2020.03.002.
7. Chong SJF, Marchi S, Petroni G, Kroemer G, Galluzzi L, Pervaiz S. Noncanonical Cell Fate Regulation by Bcl-2 Proteins. Trends in Cell Biology. 2020 Jul;30(7):537-555. doi: 10.1016/j.tcb.2020.03.004.
8. Ngoi NYL, Eu JQ, Hirpara J, Wang L, Lim JSJ, Lee SC, Lim YC, Pervaiz S, Goh BC, Wong ALA. Targeting Cell Metabolism as Cancer Therapy. Antioxid Redox Signal. 2020 Feb 10;32(5):285-308. doi: 10.1089/ars.2019.7947.
9. Hirpara JL, Subramaniam K, Bellot G, Qu J, Seah S, Loh T, Tucker-Kellogg L, Clement MV and Pervaiz S. Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP. Redox Biol. 2019 Dec16;30:101403. doi: 10.1016/j.redox.2019.101403.
10. Chong SJF, Lai JXH, Qu J, Hirpara J, Kang J, Swaminathan K, Loh T, Kumar A, Vali S, Abbasi T, Pervaiz S. A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression. Cancer Lett. 2019 Aug 10;457:151-167. doi: 10.1016/j.canlet.2019.05.009. Epub 2019 May 17. PMID: 31103719
11. Hirpara J, Eu JQ, Tan JKM, Wong AL, Clement MV, Kong LR, Ohi N, Tsunoda T, Qu J, Goh BC, Pervaiz S. Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance. Redox Biol. 2018 Dec 17:101076. doi: 10.1016/j.redox.2018.101076. [Epub ahead of print] PMID: 30642723
12. Pohl SÖ, Pervaiz S, Dharmarajan A, Agostino M. Gene expression analysis of heat-shock proteins and redox regulators reveals combinatorial prognostic markers in carcinomas of the gastrointestinal tract. Redox Biol. 2018 Nov 29. pii: S2213-2317(18)30928-5. doi: 10.1016/j.redox.2018.11.018. [Epub ahead of print] PMID: 30578123
13. Bellot GL, Dong X, Lahiri A, Sebastin SJ, Batinic-Haberle I, Pervaiz S, Puhaindran ME. MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management. Redox Biol. 2019 Jan;20:307-320. doi: 10.1016/j.redox.2018.10.014. Epub 2018 Oct 23. PMID: 30390545
14. Pervaiz S. Redox Dichotomy in Cell Fate Decision: Evasive Mechanism or Achilles Heel? Antioxid Redox Signal. 2018 Nov 1;29(13):1191-1195. doi: 10.1089/ars.2018.7586. Epub 2018 Jul 10. PMID: 29845865
15. Pohl SÖ, Agostino M, Dharmarajan A, Pervaiz S. Cross Talk Between Cellular Redox State and the Antiapoptotic Protein Bcl-2. Antioxid Redox Signal. 2018 Nov 1;29(13):1215-1236. doi: 10.1089/ars.2017.7414. Epub 2018 Feb 15. PMID: 29304561
16. Angelina C, Tan ISY, Choo Z, Lee OZJ, Pervaiz S, Chen ZX. KIF1Bβ increases ROS to mediate apoptosis and reinforces its protein expression through O 2- in a positive feedback mechanism in neuroblastoma. Sci Rep. 2017 Dec 4;7(1):16867. doi: 10.1038/s41598-017-17192-6. PMID: 29203804
17. Chong SJF, Lai JXH, Eu JQ, Bellot G, Pervaiz S. Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison. Antioxid Redox Signal, 2017. [Epub ahead of print]
18. Raman D, Foo CH, Clement MV, Pervaiz S. Breast Cancer: A Molecular and Redox Snapshot. Antioxid Redox Signal 25: 337-70, 2016.
19. Loo SY, Hirpara JL, Pandey V, Tan TZ, Yap CT, Lobie PE, Thiery JP, Goh BC, Pervaiz S, Clément MV, Kumar AP. Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma. Antioxid Redox Signal. 2016 Aug 20;25(6):283-99.
20. Iskandar K, Rezlan M, Yadav SK, Foo CH, Sethi G, Qiang Y, Bellot GL, Pervaiz S. Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production. Antioxid Redox Signal. 2016 May 10;24(14):781-94
21. Low IC, Loh T, Huang Y, Virshup DM, Pervaiz S. Sustained Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of protein phosphatase 2A-B56δ stabilizes its anti-apoptotic activity. Blood, 124(14):2223-34, Oct 2014.
22. Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S*, Clement MV*. Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast cancer. Antioxid Redox Signal, 20(15):2326-46, May 2014 (*joint senior author).
23. Low IC, Kang J, Pervaiz S 104. . Bcl-2: a prime regulator of mitochondrial redox metabolism in cancer cells. Antioxid Redox Signal. 15;15(12):2975-87, Dec 2011.
24. Velaithan, R., Kang, J., Hirpara, J.L., Loh, T., Goh, B.C., Le Bras, M., Brenner, C., Clement, M-V., and Pervaiz, S. The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its anti-apoptotic activity. Blood. 9;117(23):6214-26, June 2011.
25. Indran, I.R., Hande, M.P., Pervaiz, S. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Research, Jan; 71(1):266-276, 2011.
26. Chen ZX, and Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ., 17: 408-20, 2010.
27. Shenoy K, Wu Y, Pervaiz S. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. Mar 1;69(5):1941-50, 2009.
28. Chen, Z, X. and Pervaiz, S. Bcl-2 Induces pro-oxidant state by engaging mitochondrial respiration in tumor cells. Cell Death Diff. 14(9): 1617-27, 2007.
29. Clement, M-V., Hirpara, J.L., and Pervaiz, S. Decrease in intracellular superoxide sensitizes Bcl-2 overexpressing tumor cells to receptor- and drug-induced apoptosis independent of the mitochondria. Cell Death Diff. 10(11):1273-85, 2003.
30. Pervaiz, S., Cao, J., Chao, O. S. P., Chin, Y. Y., and Clément, M-V. Activation of the Rac GTPase inhibits apoptosis in human tumor cells. Oncogene, 20(43):6263-68, 2001.
31. Hirpara, J.L., Seyed, M.A., Dong, H., Kini, M., Pervaiz, S. Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells. Blood, 95(5): 1773-1780, 2000.
32. Pervaiz, S., Seyed, M. A., Hirpara, J. L., Clement, M-V., Loh, K. W. Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells. Blood, 93(12):4096-4108, 1999.
33. Clement, M-V., Hirpara, J., Chowdhury, S., Pervaiz, S. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95-signaling dependent apoptosis in human tumor cells. Blood, 92(3): 996-1002, 1998.