Publications

2023

HEBP1 - An early trigger for neuronal cell death and circuit dysfunction in Alzheimer's disease. Chua JJE. Seminars in cell & developmental biology, 139, 102-110.

Yu, N., Pasha, M. & Chua, J.J.E. (2024) Redox changes and cellular senescence in Alzheimer's disease. Redox Biology, 70.

Roig Adam, A., Martinez-Lopez, J.A., van der Spek, S.J.F., consortium, S., Sullivan, P.F., Smit, A.B., Verhage, M. & Hjerling-Leffler, J. (2023) Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity. Biol Direct, 18, 22.

Qu, Y., Lim, J.J., An, O., Yang, H., Toh, Y.C. & Chua, J.J.E. (2023) FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migrations. iScience, 26, 108497.

Kamarudin, J.B.M., Sun, B., Foo, A.S.C., Lim, X.Y., Judd, H., Tan, X., Tan, X.H., Razar, R., Liu, M., Zhong, J., Chua, J.J.E., Ng, C.W.Q., Goh, J.C.H., Tan, T.Z., Parikh, B.H., Su, X., Kumar, A.P., Ong, W.Y., Yamaguchi, N., Set, S.Y., Yip, G.W., Zhang, Y. & Teh, D.B.L. (2023) SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. ACS Nano, 17, 11593-11606.

Altas, B., Tuffy, L.P., Patrizi, A., Dimova, K., Soykan, T., Brandenburg, C., Romanowski, A.J., Whitten, J.R., Robertson, C.D., Khim, S.N., Crutcher, G.W., Ambrozkiewicz, M.C., Yagensky, O., Krueger-Burg, D., Hammer, M., Hsiao, H.H., Laskowski, P.R., Dyck, L., Puche, A.C., Sassoe-Pognetto, M., Chua, J.J.E., Urlaub, H., Jahn, O., Brose, N. & Poulopoulos, A. (2023) Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Biol Psychiatry.

2022

SFPQ promotes RAS-mutant cancer cell growth by modulating 5'-UTR mediated translational control of CK1α. Kok VJT, Tang JY, Eng GWL, Tan SY, Chin JTF, Quek CH, Lai WX, Lim TK, Lin Q, Chua JJE, Cheong JK. NAR Cancer. 2022 Sep 27;4(3):zcac027.

Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Trubetskoy et al. (2022). Nature, 604, 502-508.

The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders. Qu, Y., An, O., Yang, H., Toh, Y.-C. & Chua, J.J.E. (2022). Neural Regen Res, 17, 1165-1171.

FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration. Qu, Y., An, O., Yang, H., Toh, Y.-C. & Chua, J.J.E. (2022). bioRxiv, 2022.2007.2011.499073.

Phosphorylation Determines Whether Neuroligin-3 is at Excitatory or Inhibitory Synapses in Different Regions of the Brain. Altas, B., Tuffy, L.P., Patrizi, A., Dimova, K., Soykan, T., Romanowski, A.J., Robertson, C.D., Khim, S.N., Bunce, G.W., Ambrozkiewicz, M.C., Yagensky, O., Krueger-Burg, D., Hammer, M., Hsiao, H.-H., Laskowski, P.R., Dyck, L., Sassoe-Pognetto, M., Chua, J.J.E., Urlaub, H., Jahn, O., Brose, N. & Poulopoulos, A. (2022). bioRxiv.

2021

FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development. Chua, J. Y., Ng, S. J., Yagensky, O., Wanker, E. E. & Chua, J. J. E. (2021). eNeuro, doi:10.1523/ENEURO.0193-20.2021. *featured as cover slide on the home page of eNeuro.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). (2021). Klionsky, D. J. et al. Autophagy 17, 1-382, doi:10.1080/15548627.2020.1797280.

Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development. (2021). Gunaseelan, S., Wang, Z., Tong, V.K.J., Ming, S.W.S., Razar, R., Srimasorn, S., Ong, W.Y., Lim, K.L., and Chua, J.J.E. Hum Mol Genet 30, 5-20.

2020

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand. Wong, H. Y., Prasad, A., Gan, S. U., Chua, J. J. E. & Schwarz, H. (2020). Front Immunol 11, 571964, doi:10.3389/fimmu.2020.571964.

2019

Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. Yagensky, O., Kohansal-Nodehi, M., Gunaseelan, S., Rabe, T., Zafar, S., Zerr, I., Haertig, W., Urlaub, H., and Chua, J.J. (2019). eLife 8.

Role of formyl peptide receptor 2 (FPR2) in the normal brain and in neurological conditions. Ong, W.Y., and Chua, J.J.E. (2019). Neural Regen Res 14, 2071-2072.

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M.P., Cornelisse, L.N., Farrell, R.J., Goldschmidt, H.L., Howrigan, D.P., et al. (2019). Neuron 103, 217-234 e214.

2018

Deciphering the Progression of Alzheimer’s Disease by Proteomic Analysis. Yagensky, O., Nodehi, M.K., Rabe, T., Zafar, S., Zerr, I., and En Chua, J.J. (2018). Alzheimer's & Dementia 14.

S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit. Liu, C., Zhang, C.W., Lo, S.Q., Ang, S.T., Chew, K.C.M., Yu, D., Chai, B.H., Tan, B., Tsang, F., Tai, Y.K., et al. (2018). J Neurosci 38, 8364-8377.

Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Huang, H., Kapeli, K., Jin, W., Wong, Y.P., Arumugam, T.V., Koh, J.H., Srimasorn, S., Mallilankaraman, K., Chua, J.J.E., Yeo, G.W., et al. (2018). Nucleic Acids Res 46, 7323-7338.

Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth. Ho, C.F., Ismail, N.B., Koh, J.K., Gunaseelan, S., Low, Y.H., Ng, Y.K., Chua, J.J., and Ong, W.Y. (2018) Neurochemical research 43, 1587-1598.

2017

Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY. Mol Neurobiol. 55(7):5741-5756.

2016

Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. Butkevich E, Härtig W, Nikolov M, Erck C, Grosche J, Urlaub H, Schmidt CF, Klopfenstein DR, Chua JJ Sci Rep 2016; 6, 26965, doi:10.1038/srep26965.

Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis. Kohansal-Nodehi M, Chua JJ, Urlaub H, Jahn R, Czernik D eLife 2016;10.7554/eLife.14530.

The roles of microtubule-based transport at presynaptic nerve terminals. Yagensky O, Kalantary Dehagh T, Chua, JJ Front. Synaptic Neurosci. 8:3

Functions of Rab proteins at presynaptic sites. Binotti B, Jahn R, Chua, JJ Cells 5, 7

2015

The GTPase Rab26 links synaptic vesicles to the autophagy pathway. Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, *Chua JJ, *Jahn R. *Co-corresponding authors Elife. 4:e0559

2014

Macromolecular complexes at active zones: integrated nano-machineries for neurotransmitter release. Chua JJ. Cell Mol Life Sci 71:3903-3916

2013

Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. Behrens C, Binotti B, Schmidt C, Robinson CV, Chua, JJ, Kühnel K. PLoS One 8, e76355.

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boykin J, Grønborg M, Riedel D, Urlaub H, Jahn, R, Chua JJ. Neuron 78, 285-297.

Managing intracellular transport. Chua JJ, Jahn R, Klopfenstein DR. Worm 2, e21564

2012

Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. Chua JJ, Schob C, Rehbein M,Gkogkas CG, Richter D, Kindler S Sci Rep 2, 484.

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Chua JJ, Butkevich E, Worseck JM, Kittelmann M, Gronborg M, Behrmann E, Stelzl U, Pavlos NJ, Lalowski MM, Eimer S, Wanker EE, Klopfenstein DR, Jahn R Proc Natl Acad Sci U S A 109:5862-5867

2010

The architecture of an excitatory synapse. Chua, J.; Kindler, S.; Boyken, J.; Jahn, R. J Cell Sci 123:819-823

Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. Groenborg, M.; Pavlos, N. J.; Brunk, I.; Chua, J.; Muenster-Wandowski, A.; Riedel, D.; Ahnert-Hilger, G.; Urlaub, H.; Jahn, R. J Neurosci 30:2-12.

Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos, N. J.; Groenborg, M.; Riedel, D.; Chua, J. J. E.; Boyken, J.; Kloepper, T. H.; Urlaub, H.; Rizzoli, S. O.; Jahn, R. J Neurosci 30:13441-13453

2008

A novel site of action for α -SNAP in the SNARE conformational cycle controlling membrane fusion. Barszczewski, M.; Chua, J.; Stein, A.; Winter, U.; Heintzmann, R.; Zilly, F. E.; Fasshauer, D.; Lang, T.; Jahn, R. Mol Biol Cell 19:776-784

2004-2006

Differential dengue cross-reactive and neutralizing antibody responses in BALB/c and Swiss albino mice induced by immunization with flaviviral vaccines and by infection with homotypic dengue-2 virus strains. Lim CS, Chua JJ, Wilkerson J, Chow VT. Viral Immunol 19, 33-41

Recombinant non-structural 1 (NS1) protein of dengue-2 virus interacts with human STAT3β protein. Chua JJ, Bhuvanakantham R, Chow VT, Ng ML Virus Research 112, 85-94

The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. Chua JJ, Ng ML, Chow VT Virus Research 102, 151-163