Her career with the University began in August 1959 when she joined the department as an assistant lecturer in Biochemistry. It was a time when most of the early biochemistry research focused on the nutritional properties of local food. Prof Wong was a recipient of a number of awards, including ones from the Fulbright Commission and the Lee Foundation. In February 1968, she went to the Vanderbilt University in Tennesse, United States on a National Institutes of Health (NIH) grant to work on hormonal regulation of carbohydrate metabolism. By 1980, Prof Wong was promoted to Professor and the department had pivoted to diverse basic and applied research in topics ranging from diseases such as diabetes, hepatomas and blood gastrin levels in patients with duodenal ulcers to the mechanism of insulin action and flavonoid metabolism.