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Assistant Professor Daniel Teh Boon Loong

Centre For Innovation & Precision Eye Health
Departments of Ophthalmology & Anatomy
Yong Loo Lin School of Medicine
Neurobiology Programme, Life Sciences Institute
National University of Singapore

 

  Email    Google Scholar    Linkedin    Website 

Research Interests and Achievements

Our group focuses on developing translational optogenetics for direct visual restoration and in regenerative medicine for inherited retinal diseases (IRD) therapeutics. Optogenetics is the application of light and genetic engineering to photosensitize cells in response to specific wavelength of light. In cases such as Retinitis Pigmentosa (RP), optogenetics can be applied to provide visual restoration to ganglion cells bypassing the degenerated photoreceptors. Applications of optogenetics here would require ultra-sensitivity and broad absorption spectrum. We integrate our moecular optogenetics knowledge here to fit clinically relevance translation, by developing opsins that could response to a wider spectrum of photons with low intensity, in hopes of able to provide long-lasting direct visual restoration from bench to bedside.


Selected Publications

  • Asano T, Teh DBL, Yawo H. Application of Optogenetics for Muscle Cells and Stem Cells. Adv Exp Med Biol. 2021;1293:359-375. https://doi.org/10.1007/978-981-15-8763-4_23
  • Teh DBL*, Prasad A*, Jiang W, Zhang N, Wu Y, Yang H, Han S, Yi Z, Yeo Y, Ishizuka T, Wong L, Thakor N, Yawo H, Liu X, All A. Driving Neurogenesis in Neural Stem Cells with High Sensitivity Optogenetics. Neuromolecular Med. 2020 Mar;22(1):139-149. https://doi.org/10.1007/s12017-019-08573-3
  • All AH, Zeng X, Teh DBL, Yi Z, Prasad A, Ishizuka T, Thakor N, Hiromu Y, Liu X. Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation. Adv Mater. 2019 Oct;31(41):e1803474. https://doi.org/10.1002/adma.201803474
  • Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ. Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science. 2018 Feb 9;359(6376):679-684. https://doi.org/10.1126/science.aaq1144
  • Teh DBL, Bansal A, Chai C, Toh TB, Tucker RAJ, Gammad GGL, Yeo Y, Lei Z, Zheng X, Yang F, Ho JS, Bolem N, Wu BC, Gnanasammandhan MK, Hooi L, Dawe GS, Libedinsky C, Ong WY, Halliwell B, Chow EK, Lim KL, Zhang Y, Kennedy BK. A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Adv Mater. 2020 Jul;32(29):e2001459. https://doi.org/10.1002/adma.202001459
  • Han S, Samanta A, Xie X, Huang L, Peng J, Park SJ, Teh DBL, Choi Y, Chang YT, All AH, Yang Y, Xing B, Liu X. Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery. Adv Mater. 2017 May;29(18). https://doi.org/10.1002/adma.201700244