CIRC has a GE PETtrace 800 series 16MeV (proton), 8MeV (deuteron) cyclotron for radioisotope production. The accelerator is self-shielded and comes equipped with a total of six target positions : a Carbon-11 target, two water targets for the production of [18F]fluoride, and a further three target positions that are potentially available for alternative isotope production. A Procab installed beside the cyclotron allows the production of [11C]CO and [11C]HCN.
There are two Clean Room manufacturing areas at CIRC, with each comprising multiple hot cells and synthesis platforms for aseptic radioisotope manufacture. Clean Room 1 houses radiochemistry modules for the manufacture of radiotracers labelled with 11C and F18. Equipment here includes TracerLab C Pro, TracerLab MeI/M and a NEPTIS module. The Clean Room 2 suite is dedicated to longer lived isotopes and radiometallic compounds with 2 fume hoods in this area for labelling of imaging and therapeutic radionuclides. Manual and automatic platforms located here include TracerLab FX N, Scintomics GRP module and Gallium generator/labelling module.
The Quality Control laboratory is fully equipped for the release of PET/SPECT radiopharmaceuticals. Equipment for the release testing includes multiple radio-HPLCs, radioactivity detectors, Gas and Ion Chromatography systems, dose calibrator and endotoxin testers.
An analytical laboratory is adjacent to the PET Imaging suites, which includes a Perkin Elmer Wizard gamma counter, scales, centrifuges, and HPLC equipment for plasma sample analysis for unchanged radiotracer, enabling generation of input functions required for kinetic analysis and image quantification. A Swisstrace blood sampling system is also available at CIRC to allow for arterial input function analysis
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CIRC hosts two hybrid imaging scanners for Positron Emission Tomography studies. Firstly, the Siemens Biograph mMR combined PET/MR imaging system, capable of simultaneous PET and MR acquisition. The mMR also has multi-nuclear capability for alternative MR-active nuclei including carbon-13, phosphorus-31 and sodium-23. The second PET scanner available at CIRC is a 128 slice Siemens Biograph mCT PET/CT system.
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