PHM5018 – Precision Cardiometabolic Medicine
Course Overview
This course provides an integrated overview of cardiometabolic diseases, with emphasis on disease complexity spanning genetic, molecular, metabolic, environmental, and lifestyle factors. Students will explore applications of precision health and medicine, including biomarker discovery, mechanistic disease stratification, targeted therapeutics, and the use of artificial intelligence for lifestyle monitoring, risk screening, diagnosis, and clinical decision-making.
Learning Outcomes
1. Distinguish between genetic and acquired cardiovascular diseases.
2. Distinguish between genetic and acquired metabolic disorders.
3. Apply genetic, molecular, and metabolic tools for diagnosis and risk stratification of cardiometabolic diseases.
4. Describe major imaging modalities used in cardiometabolic disease diagnosis.
5. Analyse the bidirectional interactions between metabolic and cardiovascular disorders.
6. Critically evaluate the role of artificial intelligence in the prevention, diagnosis, and management of cardiometabolic diseases.
Course Outline
1. Cardiovascular system: precision machine with imprecise regulatory network
2. Concept in cardiovascular function and physiology
3. Major forms of heart diseases
4. Genetics of heart diseases
5. Environmental – genetic interaction in heart diseases.
6. The application of AI in meal and physical activity tracking.
7. Metabolic system: control of metabolic homeostasis
8. Glucose control
9. Fat control
10. Amino acid control
11. Genetics of metabolic disorders
12. Genetics and environmental factors
13. Systems genetic approach to dissect complex diseases and complex disease interactions
14. Interaction between metabolic and cardiovascular diseases
15. Genetics for diagnosis and therapy
16. The application of machine learning algorithms in prediction models for risk assessment.
17. The application of narrow and general AI tools, including future development of agentic AI in disease management, prevention, and personalized therapies.