Affliations
Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Principal Investigator, NUS Medicine Synthetic Biology Translational Research Programme
Education
| Institution and Location | Year(s) |
| Bachelor of Science, Xiamen University, China | 1998 – 2002 |
| Ph.D. , National University of Singapore, Singapore | 2003 – 2008 |
Professional Experience
| Institution and Location | Year(s) |
| Post-doc, National University of Singapore, Singapore | 2008-2010 |
| Post-doc, Massachusetts Institute of Technology/Whitehead Institute for Biomedical Sciences, US | 2010-2015 |
| Assistant/Associate Professor, City University of Hong Kong, Hong Kong | 2015-2021 |
Research Interest
Red blood cell biogenesis
Red cell therapy and gene therapy
Current Research Projects
Mechanistic study of terminal erythropoiesis
Gene therapy in hematopoietic stem cells against blood disorders and metabolic diseases
Selected Publications
- Dong H, Zhang Y, Wang J, Xiang H, Lv T, Wei L, Yang S, Liu X, Ren B, Zhang X, Liu L, Cao J, Wang M, Shi J#, Yang N#., “Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci.”, J Immunol. 2022 Jan 1;208(1):181-189. doi: 10.4049/jimmunol.2100844., (#: co-corresponding author)
- Wei L, Wang M, Xiang H, Jiang Y, Gong J, Su D, Al Azad MAR, Dong H, Feng L, Wu J, Chan LL, Yang N#, Shi J#, “Bamboo Shark as a Small Animal Model for Single Domain Antibody Production.”, Front Bioeng Biotechnol. 2021 Dec 8;9:792111. doi: 10.3389/fbioe.2021.792111. (#: co-corresponding author)
- Panbing Wang, M. A. R. Al Azad, Xiong Yang, Paolo R. Martelli, Kam Yan Cheung, Jiahai Shi#, Yajing Shen#, “Self-adaptive and efficient propulsion of Ray sperms at different viscosities enabled by heterogeneous dual helixes.” Proc Natl Acad Sci U S A. 2021, accepted, (#: co-corresponding author)
- Pham TC, Jayasinghe MK, Pham TT, Yang Y, Wei L, Usman WM, Chen H, Pirisinu M, Gong J, Kim S, Peng B, Wang W, Chan C, Ma V, Nguyen NTH, Kappei D, Nguyen XH, Cho WC, Shi J#, Le MTN#, “Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery.” J Extracell Vesicles. 2021 Feb;10(4):e12057. doi: 10.1002/jev2.12057. Epub 2021 Feb 16. (#: co-corresponding author)
- Ru Zhen, Chingyee Moo, Zhenzhen Zhao, Mengying Chen, He Feng, Xiaojun Zheng, Liang Zhang, Jiahai Shi#, Caiyong Chen#, “Wdr26 regulates nuclear condensation in developing erythroblasts” Blood, 2020 Jan 16;135(3):208-219. doi: 10.1182/blood.2019002165 (#: co-corresponding author) (cover story)
- Yuanyan Tan, Athena H. Y. Chu, Siyu Bao, Duc Anh Hoang, Firaol Tamiru Kebede, Wenjun Xiong, Mingfang Ji, Jiahai Shi#, Zongli Zheng#, “Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity”, Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20969-20976. doi: 10.1073/pnas.1906843116. Epub 2019 Sep 30 (#: co-corresponding author)
- Jiahai Shi*, Lenka Kundrat*, Novalia Pishesha, Angelina Bilate, Chris Theile, Takeshi Maruyama, Stephanie K. Dougan, Hidde Ploegh, and Harvey Lodish, “Engineered red cells as carriers for systemic delivery of a wide array of functional probes”, Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10131-6. *: Equal contribution