Academic Staff

Associate Professor
YIP Wai Cheong, George

(PhD; MBBS)

Head, Department of Anatomy, NUS

Tel: +65 6516 3206; +65 6516 3200
Email: georgeyip@nus.edu.sg; anthead@nus.edu.sg
Office: MD10 #04-01S

Research Interests
  • Roles of glycosaminoglycans and proteoglycans in breast, prostate, gastric and other cancers
  • Wound healing
Current Projects
  • Determination of the functional roles of heparan and chondroitin sulfate proteoglycans in breast cancer, evaluation of their use as biomarkers and prognostic factors, and development of therapeutic targets
  • Vacancies are available for highly motivated and enthusiastic students who are keen to pursue their postgraduate studies in this area
Selected Publications
  • Scully OJ, Shyamasundar S, Matsumoto K, Dheen ST, Yip GW, Bay BH (2023) C1QBP mediates breast cancer cell proliferation and growth via multiple potential signalling pathways. Int J Mol Sci 24:1343. [PubMed]
  • Ibrahim SA, Yip GW, Götte M (2023) Cancer stem cells as attractive targets for breast cancer therapy. Front Oncol 13:1151742. [PubMed] 
  • Hua SH, Viera M, Yip GW, Bay BH (2022) Theranostic applications of glycosaminoglycans in metastatic renal cell carcinoma. Cancers (Basel) 15:266. [PubMed]
  • Parnigoni A, Caon I, Teo WX, Hua SH, Moretto P, Bartolini B, Viola M, Karousou E, Yip GW, Götte M, Heldin P, Passi A, Vigetti D (2022) The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism. Matrix Biol 109:140-161. [PubMed] 
  • Lucanus AJ, Thike AA, Tan XF, Lee KW, Guo S, King VPC, Yap VB, Bay BH, Tan PH, Yip GW (2022) KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence. Breast Cancer Res Treat 191:63-75. [PubMed] 
  • Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP (2021) Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers. Cell Death Discov 7:265. [PubMed] 
  • Viera M, Yip GWC, Shen HM, Baeg GH, Bay BH (2021) Targeting CD82/KAI1 for precision therapeutics in surmounting metastatic potential in breast cancer. Cancers (Basel) 13:4486. [PubMed] 
  • Yip GW, Bay BH (2021) Novel therapeutics in breast cancer. Curr Med Chem 28:5032-5033. [PubMed] 
  • Troschel FM, Palenta H, Borrmann K, Heshe K, Hua SH, Yip GW, Kiesel L, Eich HT, Götte M, Greve B (2021) Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21WAF1/CIP1. J Cancer Res Clin Oncol 147:3299-3312. [PubMed] 
  • Tan XF, Chen Q, Hua SH, Yip GW (2021) Roles of interferon induced protein with tetratricopeptide repeats (IFIT) family in cancer. Curr Med Chem 28:5034-5047. [PubMed] 
  • Ng CCY, Md Nasir ND, Loke BN, Tay TKY, Thike AA, Rajasegaran V, Liu W, Lee JY, Guan P, Lim AH, Chang KTE, Gudi MA, Madhukumar P, Tan BKT, Tan VKM, Wong CY, Yong WS, Ho GH, Ong KW; International Fibroepithelial Consortium; Yip GWC, Bay BH, Tan P, Teh BT, Tan PH (2021) Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing. Mod Pathol 34:1320-1332. [PubMed] 
  • Chandrika M, Chua PJ, Muniasamy U, Huang RY, Thike AA, Ng CT, Tan PH, Yip GW, Bay BH (2021) Prognostic significance of phosphoglycerate dehydrogenase in breast cancer. Breast Cancer Res Treat 186:655-665. [PubMed]
  • Kumar Katakam S, Tria V, Sim WC, Yip GW, Molgora S, Karnvas T, Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B, Götte M (2021) The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis. FEBS J 288:486-506. [PubMed]
  • Shamshirian A, Aref AR, Yip GW, Ebrahimi Warkiani M, Heydari K, Razavi Bazaz S, Hamzehgardeshi Z, Shamshirian D, Moosazadeh M, Alizadeh-Navaei R (2020) Diagnostic value of serum HER2 levels in breast cancer: a systematic review and meta-analysis. BMC Cancer 20:1049. [PubMed]
  • Parameswaran R, Samuel M, Satish RL, Kripesh A, Moorthy V, Vajjhala R, Ng XL, Yip GW, Voon FC, Chandran M (2020) Parathyroid allotransplantation to treat post-thyroidectomy hypoparathyroidism: A review of case studies. Surgeon 19:183-192. [PubMed]
  • Shamshirian A, Hessami A, Heydari K, Navaei RA, Ebrahimzadeh MA, Yip GW, Ghasemian R, Sedaghat M, Baradaran H, Yazdi SM, Aboufazeli E, Jafarpour H, Dadgostar E, Tirandazi B, Sadeghnezhad R, Karimifar K, Eftekhari A, Shamshirian D (2020) The role of hydroxychloroquine in COVID-19: a systematic review and meta-analysis. Ann Acad Med Singap 49:789-800. [PubMed]
  • Tan XF, Teo WX, Yip GW (2019) In vitro evaluation of candidate gene targets for cancer therapy. Methods Mol Biol 1974:21-30. [PubMed]
  • Chng YS, Tristan G, Yip GW, Lam Y (2019) Protecting-group-free synthesis of chondroitin 6-sulfate disaccharide and tetrasaccharide. Org Lett 21:4559-4562. [PubMed]
  • Lucanus AJ, Yip GW (2018) Kinesin superfamily: roles in breast cancer, patient prognosis and therapeutics. Oncogene 37:833-838. [PubMed]
  • Koh VC, Thike AA, Nasir ND, Yip GW, Bay BH, Tan PH (2018) Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast. Virchows Arch 472:615-621. [PubMed]
  • Ng CT, Yip GW, Chen ES, Poh WY, Bay BH, Yung LY (2018) Gold nanoparticles induce serum amyloid A 1-Toll-like receptor 2 mediated NF-kB signaling in lung cells in vitro. Chem Biol Interact 289:81-89. [PubMed]
  • Tan SW, Yip GW, Suda T, Baeg GH (2018) Small Maf functions in the maintenance of germline stem cells in the Drosophila testis. Redox Biol 15:125-134. [PubMed]
  • Iravani O, Bay BH, Yip GW (2017) Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1. Exp Cell Res 350:380-389. [PubMed]
  • Iravani O, Yip GW, Thike AA, Chua PJ, Scully OJ, Tan PH, Bay BH (2016) Prognostic significance of Claudin 12 in estrogen receptor-negative breast cancer. J Clin Pathol 69:878-883. [PubMed]
Honours & Awards
  • Clinician Scientist Award, National Medical Research Council, Singapore, 2012 and 2019
  • National University of Singapore Annual Teaching Excellence Award, 2007/2008
  • Yong Loo Lin School of Medicine Faculty Teaching Excellence Award, 2007/2008
  • Japan Society for the Promotion of Science (JSPS) Fellowships, 2005 and 2011
  • International Fellowship, A*STAR, 2002-2003
Other Appointments
  • Editorial Board Member, The Scientific World Journal
  • Editorial Board Member, World Journal of Clinical Oncology
  • Editorial Board Member, BioScience Trends
  • Editorial Board Member, The Open Pathology Journal
  • Editorial Board Member, Glycobiology Insights
  • Editorial Board Member, Bone and Tissue Regeneration Insights
  • Editorial Board Member, Journal of Medical & Biological Sciences
  • Editorial Board Member, Annals of Microscopy
  • Coordinator, Honours Project in Life Sciences (LSM4199)
  • Coordinator, Undergraduate Research Opportunities Programme in Science (UROPS)

Department of Anatomy

  • Yong Loo Lin School of Medicine
    MD10, 4 Medical Drive
    Singapore 117594
  • +65 6516 3200
  • antsec@nus.edu.sg
     
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