Academic Staff
ONG Wei Yi
(PhD; BDS)
Chair of Steering Committee, Neurobiology Programme, Life Sciences Institute, NUS
Tel: +65 6516 3662
Email: antongwy@nus.edu.sg
Centre for Life Sciences
National University of Singapore
28 Medical Drive, #04-09, Singapore 117456
Office: MD10 #04-01L
Research Interests
- Translational Aspects of Lipid Biology in the Nervous System
- Nutraceuticals in Neurodegeneration and Ageing
Selected Publications
- Sun L, Leow DMK, Wang LC, Eio MY, Koh HWL, Khong ZJ, Narayanan G, Teo AKS, Giadone R, Sobota RM, Ng SY, Teo AKK, Ong WY, Rubin LL, Darras BT, Yeo CJJ. Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy. Muscle Nerve. 2026 Jan 22. doi: 10.1002/mus.70111. Epub ahead of print. PMID: 41567114.
- Tng TJW, Leow DMK, Goh G, Wang Z, Liu Y, Tang RMY, Lai KCL, Basil AH, Choong HC, Goh WWB, Cheah IK, Ong WY, Halliwell B, Lim KL. Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models. J Neurochem. 2025 Jul;169(7):e70168. doi: 10.1111/jnc.70168. PMID: 40696819; PMCID: PMC12284465.
- Leow DM, Cheah IK, Chen L, Ng YK, Yeo CJ, Halliwell B, Ong WY. Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. Antioxidants (Basel). 2024 Jun 5;13(6):693. doi: 10.3390/antiox13060693. PMID: 38929132; PMCID: PMC11200999.
- Leow DM, Ng YK, Wang LC, Koh HW, Zhao T, Khong ZJ, Tabaglio T, Narayanan G, Giadone RM, Sobota RM, Ng SY, Teo AKK, Parson SH, Rubin LL, Ong WY, Darras BT, Yeo CJ. Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy. J Clin Invest. 2024 May 9;134(12):e173702. doi: 10.1172/JCI173702. PMID: 38722695; PMCID: PMC11178536.
- Ha HT, Liu S, Nguyen XT, Vo LK, Leong NC, Nguyen DT, Balamurugan S, Lim PY, Wu Y, Seong E, Nguyen TQ, Oh J, Wenk MR, Cazenave-Gassiot A, Yapici Z, Ong WY, Burmeister M, Nguyen LN. Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. JCI Insight. 2024 Mar 7;9(8):e175462. doi: 10.1172/jci.insight.175462. PMID: 38451736; PMCID: PMC11141868.
- Chayaburakul K, Ong WY, Herr DR, Kobutree P, Chantra K. Differences in the ultrastructure of neurons in the spinal ganglion and dorsal rootlet between rats treated with cisplatin only versus co-administration with a sphingosine 1-phosphate receptor 2 agonist in attenuating neuropathy and allodynia. J Peripher Nerv Syst. 2023 Sep;28(3):476-489. doi: 10.1111/jns.12582. Epub 2023 Aug 3. PMID: 37483146.
- Kamarudin JBM, Sun B, Foo ASC, Lim XY, Judd H, Tan X, Tan XH, Razar RBBA, Liu M, Zhong J, Chua JJE, Ng CWQ, Goh JCH, Tan TZ, Parikh BH, Su X, Kumar AP, Ong WY, Yamaguchi N, Set SY, Yip GW, Zhang Y, Teh DBL. SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. ACS Nano. 2023 Jun 27;17(12):11593-11606. doi: 10.1021/acsnano.3c01916. Epub 2023 Jun 12. PMID: 37306553.
- Farooqui AA, Farooqui T, Sun GY, Lin TN, Teh DBL, Ong WY. COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines. 2023 Apr 15;11(4):1181. doi: 10.3390/biomedicines11041181. PMID: 37189799; PMCID: MC10135929.
- Leow DM, Cheah IK, Fong ZW, Halliwell B, Ong WY. Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells. Int J Mol Sci. 2023 Mar 13;24(6):5498. doi: 10.3390/ijms24065498. PMID: 36982572; PMCID: PMC10056831.
- Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, Lin TN. Protective Effect of Ergothioneine Against Stroke in Rodent Models. Neuromolecular Med. 2023 Jun;25(2):205-216. doi: 10.1007/s12017-022-08727-w. Epub 2022 Oct 19. PMID: 36261765.