Academic Staff
ONG Wei Yi
(PhD; BDS)
Chair of Steering Committee, Neurobiology Programme, Life Sciences Institute, NUS
Tel: +65 6516 3662
Email: antongwy@nus.edu.sg
Centre for Life Sciences
National University of Singapore
28 Medical Drive, #04-09, Singapore 117456
Office: MD10 #04-01L
Research Interests
- Translational Aspects of Lipid Biology in the Nervous System
- Nutraceuticals in Neurodegeneration and Ageing
Selected Publications
- Leow DM, Cheah IK, Chen L, Ng YK, Yeo CJ, Halliwell B, Ong WY. Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. Antioxidants (Basel). 2024 Jun 5;13(6):693. doi: 10.3390/antiox13060693. PMID: 38929132; PMCID: PMC11200999.
- Leow DM, Ng YK, Wang LC, Koh HW, Zhao T, Khong ZJ, Tabaglio T, Narayanan G, Giadone RM, Sobota RM, Ng SY, Teo AK, Parson SH, Rubin LL, Ong WY, Darras BT, Yeo CJ. Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy. J Clin Invest. 2024 May 9;134(12):e173702. doi: 10.1172/JCI173702. Epub ahead of print. PMID: 38722695; PMCID: PMC11178536.
- Ha HT, Liu S, Nguyen XT, Vo LK, Leong NC, Nguyen DT, Balamurugan S, Lim PY, Wu Y, Seong E, Nguyen TQ, Oh J, Wenk MR, Cazenave-Gassiot A, Yapici Z, Ong WY, Burmeister M, Nguyen LN. Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. JCI Insight. 2024 Mar 7;9(8):e175462. doi: 10.1172/jci.insight.175462. PMID: 38451736; PMCID: PMC11141868.
- Chayaburakul K, Ong WY, Herr DR, Kobutree P, Chantra K. Differences in the ultrastructure of neurons in the spinal ganglion and dorsal rootlet between rats treated with cisplatin only versus co-administration with a sphingosine 1-phosphate receptor 2 agonist in attenuating neuropathy and allodynia. J Peripher Nerv Syst. 2023 Sep;28(3):476-489. doi: 10.1111/jns.12582. Epub 2023 Aug 3. PMID: 37483146.
- Kamarudin JBM, Sun B, Foo ASC, Lim XY, Judd H, Tan X, Tan XH, Razar RBBA, Liu M, Zhong J, Chua JJE, Ng CWQ, Goh JCH, Tan TZ, Parikh BH, Su X, Kumar AP, Ong WY, Yamaguchi N, Set SY, Yip GW, Zhang Y, Teh DBL. SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. ACS Nano. 2023 Jun 27;17(12):11593-11606. doi: 10.1021/acsnano.3c01916. Epub 2023 Jun 12. PMID: 37306553.
- Farooqui AA, Farooqui T, Sun GY, Lin TN, Teh DBL, Ong WY. COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines. 2023 Apr 15;11(4):1181. doi: 10.3390/biomedicines11041181. PMID: 37189799; PMCID: PMC10135929.
- Leow DM, Cheah IK, Fong ZW, Halliwell B, Ong WY. Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells. Int J Mol Sci. 2023 Mar 13;24(6):5498. doi: 10.3390/ijms24065498. PMID: 36982572; PMCID: PMC10056831.
- Ong WY, Kao MH, Cheung WM, Leow DM, Cheah IK, Lin TN. Protective Effect of Ergothioneine Against Stroke in Rodent Models. Neuromolecular Med. 2023 Jun;25(2):205-216. doi: 10.1007/s12017-022-08727-w. Epub 2022 Oct 19. PMID: 36261765.
- Ong WY, Leow DM, Herr DR, Yeo CJ. What Do Randomized Controlled Trials Inform Us About Potential Disease-Modifying Strategies for Parkinson's Disease? Neuromolecular Med. 2023 Mar;25(1):1-13. doi: 10.1007/s12017-022-08718-x. Epub 2022 Jul 1. PMID: 35776238.
- Ong WY, Herr DR, Sun GY, Lin TN. Anti-Inflammatory Effects of Phytochemical Components of <i>Clinacanthus nutans</i>. Molecules. 2022 Jun 4;27(11):3607. doi: 10.3390/molecules27113607. PMID: 35684542; PMCID: PMC9182488.
- Ong WY, Satish RL, Herr DR. ACE2, Circumventricular Organs and the Hypothalamus, and COVID-19. Neuromolecular Med. 2022 Dec;24(4):363-373. doi: 10.1007/s12017-022-08706-1. Epub 2022 Apr 22. PMID: 35451691; PMCID: PMC9023728.
- Soh S, Ong WY. Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells. Cells. 2022 Jan 28;11(3):457. doi: 10.3390/cells11030457. PMID: 35159267; PMCID: PMC8834337.
- Jo J, Yang L, Tran HD, Yu W, Sun AX, Chang YY, Jung BC, Lee SJ, Saw TY, Xiao B, Khoo ATT, Yaw LP, Xie JJ, Lokman H, Ong WY, Lim GGY, Lim KL, Tan EK, Ng HH, Je HS. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations. Ann Neurol. 2021 Sep;90(3):490-505. doi: 10.1002/ana.26166. Epub 2021 Aug 10. PMID: 34288055; PMCID: PMC9543721.
- Xiang P, Chew WS, Seow WL, Lam BWS, Ong WY, Herr DR. The S1P2 receptor regulates blood-brain barrier integrity and leukocyte extravasation with implications for neurodegenerative disease. Neurochem Int. 2021 Jun;146:105018. doi: 10.1016/j.neuint.2021.105018. Epub 2021 Mar 13. PMID: 33727061.
- Gunaseelan S, Wang Z, Tong VKJ, Ming SWS, Razar RBBA, Srimasorn S, Ong WY, Lim KL, Chua JJE. Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development. Hum Mol Genet. 2021 Mar 25;30(1):5-20. doi: 10.1093/hmg/ddaa281. PMID: 33395696.
- Chua XY, Ho LTY, Xiang P, Chew WS, Lam BWS, Chen CP, Ong WY, Lai MKP, Herr DR. Preclinical and Clinical Evidence for the Involvement of Sphingosine 1-Phosphate Signaling in the Pathophysiology of Vascular Cognitive Impairment. Neuromolecular Med. 2021 Mar;23(1):47-67. doi: 10.1007/s12017-020-08632-0. Epub 2020 Nov 12. PMID: 33180310.
- Kuo X, Herr DR, Ong WY. Anti-inflammatory and Cytoprotective Effect of Clinacanthus nutans Leaf But Not Stem Extracts on 7-Ketocholesterol Induced Brain Endothelial Cell Injury. Neuromolecular Med. 2021 Mar;23(1):176-183. doi: 10.1007/s12017-020-08621-3. Epub 2020 Oct 21. PMID: 33085066.
- Koh SS, Ooi SC, Lui NM, Qiong C, Ho LT, Cheah IK, Halliwell B, Herr DR, Ong WY. Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury. Neuromolecular Med. 2021 Mar;23(1):184-198. doi: 10.1007/s12017-020-08620-4. Epub 2020 Oct 16. PMID: 33067719; PMCID: PMC7567423.