Academic Staff
BAY Boon Huat
(PhD; MBBS)
Tel: +65 6516 6139
Email: antbaybh@nus.edu.sg
Office: MD10 #04-01N
Research Interests
- The theme of my research is on the biology of cancers, in particular the utility of biological markers of malignancy as candidates for molecular-targeted cancer therapy.
- Nanotoxicology and nanomedicine.
Current Projects
- Breast cancer tumorigenesis and metastasis
Areas of Collaborative Research
- Electron microscopy studies in autophagy with Prof Paul Yen’s Research Group, Duke-NUS.
Selected Publications
- Zhang H, Guo Y, Jiao J, Qiu Y, Miao Y, He Y, Li Z, Xia C, Li L, Cai J, Xu K, Liu X, Zhang C, Bay BH, Song S, Yang Y, Peng M, Wang Y, Fan H. A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging. Nat Biomed Eng.. 2023 Mar;7(3):221-235
- Masroni MSB, Lee KW, Lee VKM, Ng SB, Law CT, Poon KS, Lee BT, Liu Z, Tan YP, Chng WL, Tucker S, Ngo LS, Yip GWC, Nga ME, Hue SSS, Putti TC, Bay BH, Lin Q, Zhou L, Hartman M, Loh TP, Lakshmanan M, Lee SY, Tergaonkar V, Chua H, Lee AVH, Yeo EYM, Li MH, Chang CF, Kee Z, Tan KM, Tan SY, Koay ES, Archetti M, Leong SM. Dynamic altruistic cooperation within breast tumors. Mol Cancer. 2023 Dec 14;22(1):206
- Crombie EM, Kim S, Adamson S, Dong H, Lu TC, Wu Y, Wu Y, Levy Y, Stimple N, Lam WMR, Hey HWD, Withers DJ, Hsu AL, Bay BH, Ochala J, Tsai SY. Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity. doi: 10.1002/jcsm.13121. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):198-213.
- Wong DCP, Pan CQ, Er SY, Thivakar T, Rachel TZY, Seah SH, Chua PJ, Jiang T, Chew TW, Chaudhuri PK, Mukherjee S, Salim A, Aye TA, Koh CG, Lim CT, Tan PH, Bay BH, Ridley AJ, Low BC The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration. .Mol Biol Cell. 2023 Mar 1;34(3):ar13
- Scully OJ, Shyamasundar S, Matsumoto K, Dheen ST, Yip GW, Bay BH. C1QBP Mediates Breast Cancer Cell Proliferation and Growth via Multiple Potential Signalling Pathways. Int J Mol Sci. 2023 Jan 10;24(2):1343.
- Chen XY, Yung LL, Tan PH, Bay BH. Harnessing the Immunogenic Potential of Gold Nanoparticle-Based Platforms as a Therapeutic Strategy in Breast Cancer Immunotherapy: A Mini Review. Front Immunol. 2022 Mar 31;13:865554.
- Liu H, Sun R, Wang L, Chen X, Li G, Cheng Y, Zhai G, Bay BH, Yang F, Gu N, Guo Y, Fan H. Biocompatible Iron Oxide Nanoring-Labeled Mesenchymal Stem Cells: An Innovative Magnetothermal Approach for Cell Tracking and Targeted Stroke Therapy. ACS Nano. 2022 Nov 22;16(11):18806-18821.
- Chang HC, Tao RN, Tan CT, Wu YJ, Bay BH, Yu VC. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Autophagy. 2021 Nov;17(11):3725-3739. Autophagy. 2021 Nov;17(11):3725-3739.
- Viera M, Yip GWC, Shen HM, Baeg GH, Bay BH. Targeting CD82/KAI1 for Precision Therapeutics in Surmounting Metastatic Potential in Breast Cancer. Cancers (Basel). 2021 Sep 6;13(17):4486.
- Kosok M, Alli-Shaik A, Bay BH, Gunaratne J. Comprehensive Proteomic Characterization Reveals Subclass-Specific Molecular Aberrations within Triple-negative Breast Cancer. iScience. 2020 Feb 21;23(2):100868.
- Zhu J, Sevencan C, Zhang M, McCoy RSA, Ding X, Ye J, Xie J, Ariga K, Feng J, Bay BH, Leong DT. Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy. ACS Nano. 2020 Mar 24;14(3):3259-3271.
- Lan Y, Ng CT, Ong RXS, Muniasamy U, Baeg GH, Ong CN, Yu LE, Bay BH. Urban PM2.5 reduces angiogenic ability of endothelial cells in an alveolar-capillary co-culture lung model. Ecotoxicol Environ Saf. 2020 Oct 1;202:110932.
Honours & Awards
- Kwan Im Thong Hood Cho Temple Professorship 2019-2027
- NUS Medicine Special Recognition Award for AY 2022/2023
- World’s Top 2% Most Cited Scientists (2023) according to Stanford University
- Singapore National Day Award 2013 Public Administration (Bronze)
- Faculty Outstanding Researcher Award 2007
- Awarded the Excellent Teacher Award (Top 100) AY 2003/2004 of NUS.
- Awarded Faculty Teaching Excellence Award AY 2003/2004 in Faculty of Medicine of NUS.
- Awarded Faculty Teaching Excellence Award AY 2003/2004 in Faculty of Science of NUS.
- Awarded the Excellent Teacher Award (Top 100) AY 2002/2003 of NUS.
- Awarded Faculty Teaching Excellence Award AY 2004/2005 in Faculty of Science of NUS
- JSPS Fellowship at RIKEN Institute, Japan 2001 and 2010
- Commonwealth Medical Fellowship at Oxford University (1993-1994)
Other Appointments
- Member of the Faculty Promotion and Tenure Committee, NUS Medicine
- Member of the Faculty Teaching Excellence Committee, NUS Medicine
- Associate Editor, Anatomical Sciences Education
Professional Organizations
- Past President - Microscopy Society (Singapore) (1998-2000; 2001-2002)