Department of Orthopaedic Surgery

Prof LEE Eng Hin

 

Academic Appointments:

  • Professor
    Department of Orthopaedic Surgery
    Yong Loo Lin School of Medicine
    National University of Singapore
  • Programme Leader
    NUS Tissue Engineering Programme (NUSTEP)
    Life Science Institute
    National University of Singapore

 

Clinical Appointments:

  • Emeritus Consultant
    Division of Paediatric Orthopaedics
    University Orthopaedics, Hand & Reconstructive Microsurgery Cluster
    National University Health System, Singapore
  • Senior Consultant
    Department of Orthopaedic Surgery
    KK Women's and Children's Hospital, Singapore

 

Other Appointments

  • Senior Fellow
    Agency for Science, Technology and Research
  • Senior Advisor
    Division of Graduate Medical Studies
    Yong Loo Lin School of Medicine
    National University of Singapore, Singapore

 

Qualifications

  • M.D., University of Western Ontario, Canada
  • F.R.C.S., (C) Orthopaedic Surgery, Canada
  • F.A.M.S., (Orthopaedics), Singapore
  • F.R.C.S., (Edin) Ad Hominem
  • F.R.C.S., (Glas) Ad Eundem

 

Awards and Prizes

  • Outstanding Clinician Mentor Award
  • Outstanding Researcher Award, NUS
  • Outstanding Researcher Award, YLL School of Medicine, NUS
  • The Public Service Medal (PBM)
  • The President's Social Service Award
  • The Public Administration Medal (Silver)
  • Lee Foundation –NHG Lifetime Achievement Award
  • Emeritus Consultant, National University Health System

 

Research Areas of Interests

Musculoskeletal Tissue Engineering

  1. Platform technologies
  • Cell and tissue culture and expansion
  • Stem cell biology: characterization and differentiation of mesenchymal stem cells
  • Biomaterials: biodegradable scaffolds for hard and soft tissues
  • Matrix biology and biomolecules
  1. Translational research
  • Repair and regeneration of physis
  • Repair and regeneration of articular cartilage
  • Tissue engineer ligaments and tendons

Paediatric Orthopaedics & Rehabilitation

  1. Neuromuscular Disorders (especially Gait Analysis)
  2. Congenital deformities of spine and extremities
  3. Orthopaedic trauma in children (especially physeal injuries)

 

Selected Research Projects

  • Generating a high quality immortal mesenchymal stem cell line for chondrogenesis
  • Modeling growth plate function with bone marrow derived mesenchymal stem cells to develop improved treatments for growth plate defects in children.
  • Development of xeno-/serum free medium to improve the safety and quality of human chondrocytes culture for clinical autologous chondrocyte implantation
  • Chondrogenic differentiation of human stem cells: Characterising and defining the cellular and molecular mechanisms and the establishment of stable cellular phenotypes for cartilage regeneration
  • The study of gene-enhanced bone marrow mesenchymal stem cells for articular cartilage repair in pig model

 

Selected Publications

Prof. Lee Eng Hin's Publication List

  • Engineering cell matrix interactions in assembled polyelectrolyte fiber hydrogels for mesenchymal stem cell chondrogenesis.
    Biomaterials (2014)
    Deepak Raghothaman , Meng Fatt Leong , Tze Chiun Lim , Jerry K C Toh , Andrew C A Wan , Zheng Yang , Eng Hin Lee
  • Evidence-Based Status of Osteochondral Cylinder Transfer Techniques: A Systematic Review of Level I and II Studies.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association , Volume 30 , Issue 4 (2014)
    Deepak Goyal , Sohrab Keyhani , Anjali Goyal , Eng Hin Lee , James H P Hui , Arash Sharafat Vaziri
  • Substrate topography determines the fate of chondrogenesis from human mesenchymal stem cells resulting in specific cartilage phenotype formation.
    Nanomedicine : nanotechnology, biology, and medicine (2014)
    Ying-Nan Wu , Jaslyn Bee Khuan Law , Ai Yu He , Hong Yee Low , James H P Hui , Chwee Teck Lim , Zheng Yang , Eng Hin Lee
  • The influence of scaffold microstructure on chondrogenic differentiation of mesenchymal stem cells.
    Biomedical materials (Bristol, England) , Volume 9 , Issue 3 (2014)
    Jingjing Zhang , Yingnan Wu , Tanushree Thote , Eng Hin Lee , Zigang Ge , Zheng Yang
  • The effect of fibrin glue on tendon healing and adhesion formation in a rabbit model of flexor tendon injury and repair.
    Journal of plastic surgery and hand surgery (2013)
    Min He , Aaron W T Gan , Aymeric Y T Lim , James C H Goh , James H P Hui , Eng Hin Lee , Alphonsus K S Chong
  • Evidence-Based Status of Microfracture Technique: A Systematic Review of Level I and II Studies.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association , Volume 29 , Issue 9 (2013)
    Deepak Goyal , Sohrab Keyhani , Eng Hin Lee , James Hoi Po Hui
  • Evidence-Based Status of Second- and Third-Generation Autologous Chondrocyte Implantation Over First Generation: A Systematic Review of Level I and II Studies.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association , Volume 29 , Issue 11 (2013)
    Deepak Goyal , Anjali Goyal , Sohrab Keyhani , Eng Hin Lee , James H P Hui
  • Injectable Cultured Bone Marrow-Derived Mesenchymal Stem Cells in Varus Knees With Cartilage Defects Undergoing High Tibial Osteotomy: A Prospective, Randomized Controlled Clinical Trial With 2 Years' Follow-up.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association , Volume 29 , Issue 12 (2013)
    Keng Lin Wong , Kevin Boon Leng Lee , Bee Choo Tai , Ping Law , Eng Hin Lee , James H P Hui
  • Improved Mesenchymal Stem Cells Attachment and In Vitro Cartilage Tissue Formation on Chitosan-Modified Poly(l-Lactide-co-Epsilon-Caprolactone) Scaffold.
    Tissue engineering. Part A , Volume 18 , Issue 3-4 (2012)
    Zheng Yang , Yingnan Wu , Chao Li , Tianting Zhang , Yu Zou , James H P Hui , Zigang Ge , Eng Hin Lee
  • Sequential differentiation of mesenchymal stem cells in an agarose scaffold promotes a physis-like zonal alignment of chondrocytes.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society , Volume 30 , Issue 11 (2012)
    Jacqueline Frida Schmitt , See Kwee Hua , Yang Zheng , James Hui Hoi Po , Lee Eng Hin