Department of Orthopaedic Surgery

Prof LEE Eng Hin


Academic Appointments:

  • Professor
    Department of Orthopaedic Surgery
    Yong Loo Lin School of Medicine
    National University of Singapore
  • Principal Investigator
    NUS Tissue Engineering Programme (NUSTEP)


Clinical Appointments:

  • Emeritus Consultant
    Division of Paediatric Orthopaedics
    University Orthopaedics, Hand & Reconstructive Microsurgery Cluster
    National University Health System, Singapore
  • Senior Consultant
    Department of Orthopaedic Surgery
    KK Women's and Children's Hospital, Singapore


Other Appointments

  • Senior Fellow
    Agency for Science, Technology and Research
  • Senior Advisor
    Division of Graduate Medical Studies
    Yong Loo Lin School of Medicine
    National University of Singapore, Singapore



  • M.D., University of Western Ontario, Canada
  • F.R.C.S., (C) Orthopaedic Surgery, Canada
  • F.A.M.S., (Orthopaedics), Singapore
  • F.R.C.S., (Edin) Ad Hominem
  • F.R.C.S., (Glas) Ad Eundem


Awards and Prizes

  • Outstanding Clinician Mentor Award
  • Outstanding Researcher Award, NUS
  • Outstanding Researcher Award, YLL School of Medicine, NUS
  • The Public Service Medal (PBM)
  • The President's Social Service Award
  • The Public Administration Medal (Silver)
  • Lee Foundation –NHG Lifetime Achievement Award
  • Emeritus Consultant, National University Health System


Research Areas of Interests

Musculoskeletal Tissue Engineering

  1. Platform technologies
  • Cell and tissue culture and expansion
  • Stem cell biology: characterization and differentiation of mesenchymal stem cells
  • Biomaterials: biodegradable scaffolds for hard and soft tissues
  • Matrix biology and biomolecules
  1. Translational research
  • Repair and regeneration of physis
  • Repair and regeneration of articular cartilage
  • Tissue engineer ligaments and tendons

Paediatric Orthopaedics & Rehabilitation

  1. Neuromuscular Disorders (especially Gait Analysis)
  2. Congenital deformities of spine and extremities
  3. Orthopaedic trauma in children (especially physeal injuries)


Selected Research Projects

  • Generating a high quality immortal mesenchymal stem cell line for chondrogenesis
  • Modeling growth plate function with bone marrow derived mesenchymal stem cells to develop improved treatments for growth plate defects in children.
  • Development of xeno-/serum free medium to improve the safety and quality of human chondrocytes culture for clinical autologous chondrocyte implantation
  • Chondrogenic differentiation of human stem cells: Characterising and defining the cellular and molecular mechanisms and the establishment of stable cellular phenotypes for cartilage regeneration
  • The study of gene-enhanced bone marrow mesenchymal stem cells for articular cartilage repair in pig model


Selected Publications

Prof. Lee Eng Hin's Publication List (external site)