Our Vision
- To advance our understanding of the mechanisms of human diseases with the aid of the state-of-the-art multi-omics technologies integrated with environmental, lifestyle and healthcare data
- To develop insights into novel ways to treat and prevent diseases.
Our Mission
- To build a community of scientists and clinicians committed to optimizing health and improve disease management of individuals
director's MESSAGE
“By understanding the mechanisms of human diseases, we aim to identify novel therapeutic targets which can be modulated to treat or prevent disease.”
Professor Kevin White
Programme Director
Professor Tai E Shyong
Deputy Programme Director
get to know about our
research areas and the members behind them
Human Genetics, Metabolic Diseases & Cohort Studies
Functional Genomics
Metabolomics / Lipidomics
Computational Biology & Bioinformatics
Nucleic Acid Technologies
Human Genetics, Metabolic Diseases & Cohort Studies
Genome sequences of 100,000 Singaporeans are coordinated and generated by PRECISE, a central entity to oversee the National Precision Medicine Programme in Singapore
Sim Xueling
Associate Professor
Area of Research
- Statistical Genetics
- Pharmacogenomics
- Biostatistics
Research Interests
- Multi-ethnic Cohorts
- Precision Medicine
Tai E Shyong
Deputy Programme Director
Professor
Area of Research
- Metabolic diseases & Diabetes: Cellular & Molecular mechanisms, Genetics & nutrition, Therapy
Research Interests
- Mobile health & behavioural science related to health
- Insulin resistance & its genetics
- Diabetes
Liu Boxiang
Assistant Professor
Area of Research
- GWAS, Statistical method development, Machine Learning models, Natural Language Processing (NLP),
Computer Vision, Deep Learning
Research Interests
- GWAS of genetic variants with complex human diseases
- Expression Quantitative Trait Loci (eQTL) mapping
- Deep learning architecture integrated with cis- & trans-regulators of gene expression
Functional Genomics
Genome sequences of 100,000 Singaporeans are coordinated and generated by PRECISE, a central entity to oversee the National Precision Medicine Programme in Singapore
Jay Shin
Adjunct Associate
Professor
Area of Research
- Non-coding DNA and RNA Elements
Research Interests
- Decoding Non-coding Elements by Developing Break-through Genomic Technologies and Automations for Large-scale Assays
- Non-coding Elements for Precision Medicine
- Clinical Diagnosis
- Medical Intervention
Yu Haojie
Assistant Professor
Area of Research
- Cardiovascular diseases: Cellular & Molecular Mechanism, Genetics
- Metabolic Diseases & Diabetes: Cellular & Molecular Mechanisms, Genetics & Nutrition
Research Interests
- Hypercholesterolemia Atherosclerotic Plaque Progression & Regression Functional Genomics & Cardiometabolic Disease Genome editing
Teo Kee Keong Adrian
Assistant Professor
Area of Research
- Metabolic Diseases & Diabetes: Cellular & Molecular Mechanisms, Stell Cell Biology
Research Interests
- Stem Cell
- iPSCs
- Diabetes
- Pancreas
- Islet beta-cells
- Human development
- Precision medicine
Metabolomics / Lipidomics
Genome sequences of 100,000 Singaporeans are coordinated and generated by PRECISE, a central entity to oversee the National Precision Medicine Programme in Singapore
Hyungwon Choi
Associate Professor
Area of Research
- Computational Biology
Research Interests
- Multi-omics Integration
- Mass Spectrometry Informatics
- Biomarker Discovery & Characterization
Amaury Gassiot Cazenave
Research Assistant Professor
Area of Research
- Synthetic Biology: Proteomics & Lipidomics
Research Interests
- Mass Spectrometry
- Metabolomics
Federico Tesio Torta
Research Assistant Professor
Area of Research
- Synthetic Biology: Proteomics & Lipidomics
Research Interests
- Mass Spectrometry
- Clinical lipidomics
- Protein-lipid interactions
- Signalling lipids
Computational Biology & Bioinformatics
Genome sequences of 100,000 Singaporeans are coordinated and generated by PRECISE, a central entity to oversee the National Precision Medicine Programme in Singapore
Liu Boxiang
Assistant Professor
Area of Research
- GWAS, Statistical method development, Machine Learning models, Natural Language Processing (NLP),
Computer Vision, Deep Learning
Research Interests
- GWAS of genetic variants with complex human diseases
- Expression Quantitative Trait Loci (eQTL) mapping
- Deep learning architecture integrated with cis- & trans-regulators of gene expression
Hyungwon Choi
Associate Professor
Area of Research
- Computational Biology
Research Interests
- Multi-omics Integration
- Mass Spectrometry Informatics
- Biomarker Discovery & Characterization
Lee Guat Lay, Caroline
Associate Professor
Area of Research
- Functional Ageing: Cellular & Molecular Mechanisms
Research Interests
- Next-Generation Sequencing
- Metagenomics
- Hepatocellular Carcinoma
- Cancer Genomics
- Pharmacogenomics
Nucleic Acid Technologies
Genome sequences of 100,000 Singaporeans are coordinated and generated by PRECISE, a central entity to oversee the National Precision Medicine Programme in Singapore
Jay Shin
Adjunct Associate
Professor
Area of Research
- Non-coding DNA and RNA Elements
Research Interests
- Decoding Non-coding Elements by Developing Break-through Genomic Technologies and Automations for Large-scale Assays
- Non-coding Elements for Precision Medicine
- Clinical Diagnosis
- Medical Intervention
Yang Yi Yan
Adjunct Research
Professor
Area of Research
- Bioengineering
- Non-viral Biopolymers / Polypeptides
- Antimicrobial & Antiviral Biopolymers / Polypeptides
- Microneedles Platforms
- Metal-cluster Based Antimicrobial Coatings
- Biomaterials for Soft Medical Implants & Coatings
Research Interests
- Drug and Gene Delivery
- Polymer-based Gene Delivery Nanocarriers
- Non-viral Nanocarriers for Targeted Delivery of Mrna Vaccine
Hu Chunyi
Assistant Professor
Area of Research
- CRISPRS-Cas Immunity System
Research Interests
- Molecular Mechanisms
- Supramolecular complexes in immunity systems
- Adaptive immunity systems
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