Summary
mRNA therapy, which possesses distinctive advantages over DNA and protein-based therapies, has immense potential for diverse applications, including mRNA vaccines, protein-replacement therapy, gene editing, and cell reprogramming. Nevertheless, successful mRNA therapy requires the production of stable mRNA with minimal immunogenicity and establishment of a safe and effective delivery system. Polymeric mRNA delivery vehicles have attracted great interest recently and developed quickly rendered by endless synthetic capability, versatile structure, and robust stability. In this review, firstly, we summarize the development of polymeric nanocarriers for mRNA delivery. Secondly, the approaches to enhance mRNA transfection efficiency are emphatically discussed, involving tuning the polymer structure, engineering the polymeric nanoparticles, and improving efficiency in the mRNA delivery process. Finally, conclusions and perspectives are proposed for mRNA therapy, especially regarding acceleration of their clinical translation. We believe that introduction of mRNA will lead to next-generation promising techniques for disease prevention and treatment in the near future.
Read More: https://www.sciencedirect.com/science/article/abs/pii/S259023852200114X
