A “Self-Checking” pH/Viscosity-Activatable NIR-II Molecule for Real-Time Evaluation of Photothermal Therapy Efficacy
![](https://medicine.nus.edu.sg/trp/nanomedicine/wp-content/uploads/sites/9/2022/04/anie202200025-fig-0001-m.jpg)
Abstract A second near-infrared (NIR-II) self-checking molecule, LET-1052, was developed for visualizing intracellular viscosity change and immediately predicting therapeutic efficacy of tumour turn-on photothermal therapy. We present a second near-infrared (NIR-II) self-checking molecule, LET-1052, for acidic tumor microenvironment (TME) turn-on photothermal therapy (PTT), followed by viscosity based therapeutic efficacy evaluation by itself in two independent […]