Research Themes
Define molecular and cellular mechanisms of immune-regulation, targets and lead molecules and harness them to design new strategies restoring immune homeostasis to prevent and treat infectious, inflammatory diseases and cancers.
Characterize the Asian Immune phenotypes within our population groups with a view towards personalized diagnosis and new treatment guidelines; and to develop and circulate novel approaches to diagnose disease, guide treatment and measure therapy efficacy
Team Leads
A/Prof Paul MacAry
Coordinator
Key Areas of Research
- Human Antibody Discovery and Engineering
- Alloantibody
- Dengue Virus Antibodies
Dr Makoto Yawata
Coordinator
Key Areas of Research
- Immunological mechanisms of NK cell responses in cancer and infectious diseases
- Computational characterization of genetic and functional diversification in human NK cell repertoires
- Phenotypes and functions of organ-specific NK cells in health and disease
Dr Tay Sen Hee Frank
Coordinator
Key Areas of Research
- Systemic lupus erythematosus
- Nonsteroidal anti-inflammatory drug hypersensitivity
- Immune-related adverse effects
- Neutrophils
- Epigenetics
Team Members
Dr Amanda Chan Chee Yun
Key Areas of Research
- Small fiber neuropathies
- Autonomic disorders
- Neurological sleep disorders
Dr Benoit Malleret
Key Areas of Research
- Human and zoonotic malaria
- Gut microbiome dysbiosis
- Electron microscopy
A/Prof Chen Jinmiao
Key Areas of Research
- Single-cell omics, Spatial omics, AI, Immunology.
- Developing novel analytical methods and databases for the integration and analyses of single-cell and spatial omics data.
Dr Jonathan Lee Wei Jie
Key Areas of Research
- Investigating the role of the gut microbiome in gastrointestinal cancers.
- Develop predictive microbial markers and targeted therapies for gastrointestinal cancers.
A/Prof Lu Jinhua
Key Areas of Research
- Cancer vaccines: antigens & adjuvants
- Systemic lupus erythematosus (SLE): alarmins & autoantibodies
- Complement: C1q & C1 proteases
A/Prof Veronique Angeli
Key Areas of Research
- Lymphatic vessel biology and functions
- Lymphedema
- Tissue-resident macrophages
- Cardiovascular and metabolic diseases