Research Themes

Define molecular and cellular mechanisms of immune-regulation, targets and lead molecules and harness them to design new strategies restoring immune homeostasis to prevent and treat infectious, inflammatory diseases and cancers.

Define molecular and cellular mechanisms of immune-regulation, targets and lead molecules and harness them to design new strategies restoring immune homeostasis to prevent and treat infectious, inflammatory diseases and cancers.

Team Leads

A/Prof Zhang Yongliang

Coordinator

Key Areas of Research

  • Immune response to infection and cancer
  • Signal transduction in cancer development
  • Dual-specificity phosphatases (DUSPs)

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Dr Chen Kaiwen

Coordinator

Key Areas of Research

  • Innate immunity and inflammation
  • Programmed cell death
  • Host-pathogen interactions

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Team Members

Dr Benoit Malleret

Key Areas of Research

  • Human and zoonotic malaria
  • Gut microbiome dysbiosis
  • Electron microscopy

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A/Prof Chen Jinmiao

Key Areas of Research

  • Single-cell omics, Spatial omics, AI, Immunology.
  • Developing novel analytical methods and databases for the integration and analyses of single-cell and spatial omics data.

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Dr Jonathan Lee Wei Jie

Key Areas of Research

  • Investigating the role of the gut microbiome in gastrointestinal cancers.
  • Develop predictive microbial markers and targeted therapies for gastrointestinal cancers.

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A/Prof Lina Lim Hsiu Kim

Key Areas of Research

  • Annexin-A1
  • Macrophages and Dendritic cells in the Tumor microenvironment
  • Impact of Stress on cancer and inflammation

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A/Prof Liu Haiyan

Key Areas of Research

  • Adoptive immunotherapy
  • Cancer vaccines
  • Tumor microenvironment
  • Innate immune cell subsets, including ILCs, NK cells and γδT cells

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A/Prof Lu Jinhua

Key Areas of Research

  • Cancer vaccines: antigens & adjuvants
  • Systemic lupus erythematosus (SLE): alarmins & autoantibodies
  • Complement: C1q & C1 proteases

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A/Prof Nguyen Nam Long

Key Areas of Research

  • Sphingosine-1-phosphate transport and signaling
  • Nutrient transport at blood-brain barrier
  • Lysosomal transport pathways for small molecules
  • Lysolipid transport and functions

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Prof Nicholas Gascoigne

Key Areas of Research

  • CAR-T cells
  • T cell activation and signalling
  • T cell development
  • Microbiome effect on T cell differentiation

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Dr Peh Hong Yong

Key Areas of Research

  • Resolution of inflammation
  • Pro-resolving lipid mediators (lipoxins, resolvins, maresins, protectins) and eicosanoids
  • Inflammation and inflammaging
  • Macrophage efferocytosis

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Dr Tay Sen Hee Frank

Key Areas of Research

  • Systemic lupus erythematosus
  • Nonsteroidal anti-inflammatory drug hypersensitivity
  • Immune-related adverse effects
  • Neutrophils
  • Epigenetics

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A/Prof Veronique Angeli

Key Areas of Research

  • Lymphatic vessel biology and functions
  • Lymphedema
  • Tissue-resident macrophages
  • Cardiovascular and metabolic diseases

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