Research Themes
Define molecular and cellular mechanisms of immune-regulation, targets and lead molecules and harness them to design new strategies restoring immune homeostasis to prevent and treat infectious, inflammatory diseases and cancers.
Define molecular and cellular mechanisms of immune-regulation, targets and lead molecules and harness them to design new strategies restoring immune homeostasis to prevent and treat infectious, inflammatory diseases and cancers.
Team Leads
A/Prof Zhang Yongliang
Coordinator
Key Areas of Research
- Immune response to infection and cancer
- Signal transduction in cancer development
- Dual-specificity phosphatases (DUSPs)
Dr Chen Kaiwen
Coordinator
Key Areas of Research
- Innate immunity and inflammation
- Programmed cell death
- Host-pathogen interactions
Team Members
Dr Benoit Malleret
Key Areas of Research
- Human and zoonotic malaria
- Gut microbiome dysbiosis
- Electron microscopy
Dr Jonathan Lee Wei Jie
Key Areas of Research
- Investigating the role of the gut microbiome in gastrointestinal cancers.
- Develop predictive microbial markers and targeted therapies for gastrointestinal cancers.
A/Prof Lina Lim Hsiu Kim
Key Areas of Research
- Annexin-A1
- Macrophages and Dendritic cells in the Tumor microenvironment
- Impact of Stress on cancer and inflammation
A/Prof Liu Haiyan
Key Areas of Research
- Adoptive immunotherapy
- Cancer vaccines
- Tumor microenvironment
- Innate immune cell subsets, including ILCs, NK cells and γδT cells
A/Prof Lu Jinhua
Key Areas of Research
- Cancer vaccines: antigens & adjuvants
- Systemic lupus erythematosus (SLE): alarmins & autoantibodies
- Complement: C1q & C1 proteases
A/Prof Nguyen Nam Long
Key Areas of Research
- Sphingosine-1-phosphate transport and signaling
- Nutrient transport at blood-brain barrier
- Lysosomal transport pathways for small molecules
- Lysolipid transport and functions
Prof Nicholas Gascoigne
Key Areas of Research
- CAR-T cells
- T cell activation and signalling
- T cell development
- Microbiome effect on T cell differentiation
Dr Peh Hong Yong
Key Areas of Research
- Resolution of inflammation
- Pro-resolving lipid mediators (lipoxins, resolvins, maresins, protectins) and eicosanoids
- Inflammation and inflammaging
- Macrophage efferocytosis
Dr Tay Sen Hee Frank
Key Areas of Research
- Systemic lupus erythematosus
- Nonsteroidal anti-inflammatory drug hypersensitivity
- Immune-related adverse effects
- Neutrophils
- Epigenetics
A/Prof Veronique Angeli
Key Areas of Research
- Lymphatic vessel biology and functions
- Lymphedema
- Tissue-resident macrophages
- Cardiovascular and metabolic diseases