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CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance

CAR-T therapy is often very costly and not effective in killing solid tumours.

Prof Nicholas Gascoigne, Dr Wu Ling and team have discovered the by manipulating the signalling molecules in the CAR-T cells, the efficacy of these cells can be improved so that they have a better ability to persist in the host and to kill the tumour. This also improves the CAR-T function in a solid tumour model. 

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00002-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379123000022%3Fshowall%3Dtrue

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