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Brian Kennedy Laboratory

Advancing Healthy Longevity Through Innovative Research

Centre for Healthy Longevity • National University Health System
Healthy Longevity Translational Research Programme • National University of Singapore
Brian Kennedy

Brian Kennedy

Distinguished Professor & Lab Director
bkennedy@nus.edu.sg
Research Focus
Biology of ageing and translational research for healthy longevity interventions
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Research Assistant Professors

Esther Wong

Wong Siew Peng Esther

Research Assistant Professor
Research Focus
I am a researcher specializing in autophagy and neurodegeneration, utilizing mammalian cellular systems, pathological, and aging animal models to investigate autophagy’s role in health, aging, and neurodegenerative diseases. At the Centre for Healthy Longevity, I lead animal intervention studies and stem cell platforms under the Healthy Longevity Translational Research Programme, testing repurposed drugs, natural products, and geroprotectors to enhance autophagy, extend healthspan, and mitigate age-related pathologies.

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Jorming Goh

Jorming Goh

Research Assistant Professor
Research Focus
Expert in molecular mechanisms of aging and longevity research with emphasis on cellular pathways: Exercise Immunology and Oncology; Damage-Associated Molecular Patterns (DAMPs); Exerkines, Inflammation; Integrative Exercise Physiology; Aging Biology; Cardiometabolic Disease. Link: https://medicine.nus.edu.sg/phys/about-us/academic-staff/research-track/goh-jor-ming/

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Karen Crasta

Karen Crasta

Research Assistant Professor
Research Focus
Seeks to understand cellular stress response and adaptation from the chromosomal instability perspective, while investigating translational potential of improving mitotic fidelity for ageing.
  • Therapy-induced senescence and tumour recurrence
  • Chromosome instability as driver of inflammation in age-related disease
  • Extracellular vesicles as means of systemic communication in healthy longevity
  • Impact of aged tumour microenvironment in cancers
Lab website: https://www.crastalab.com/

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Senior Research Fellows

Guan Shou Ping

Guan Shou Ping

Senior Research Fellow
Research Focus
Research interests focus on elucidating the fundamental mechanisms of aging and developing strategies to enhance the efficacy of antitumor drug therapies.
Lee Han Qing Jasinda

Lee Han Qing Jasinda

Senior Research Fellow
Research Focus
Investigating how supplements and repurposed drugs can improve health-span in aged mice.
Sheeja Navakkode

Sheeja Navakkode

Senior Research Fellow
Research Focus
My research focuses on Aging and Alzheimer's disease, specifically how they affect hippocampus-dependent memory. I aim to understand the underlying mechanisms and explore ways to alleviate memory loss.
Mohammad Alfatah

Mohammad Alfatah

Senior Research Fellow
Research Focus
My research focuses on identifying chemical, genetic, and metabolic factors that protect against cellular decline during chronological aging and oxidative stress, using both yeast and human cell models.

Research Fellows

Hataitip Tasena

Hataitip Tasena

Research Fellow
Research Focus
Combining research experiences with management skills, this role assists the Programme Director in enhancing team performance by optimising workflows, fostering collaboration, nurturing young researchers, and promoting a positive workplace culture.
FuKai Zhang

FuKai Zhang

Research Fellow
Research Focus
My research interests primarily focus on developing mesenchymal stromal cell therapies to promote healthy longevity using mouse models. Mechanistically, I am also interested in exploring how RNA processing regulates the ageing process, utilizing cerebral organoid models.
Thein Fen Shermaine

Thein Fen Shermaine

Research Fellow
Research Focus
Identifying novel compounds that extend healthy longevity, with particular interest in those that may modulate nutrient signalling pathways.
Maximilian Unfried

Maximilian Unfried

Research Fellow
Research Focus
Max is interested in uncovering the determinants of maximum lifespan and their connection to aging and rejuvenation, using tools from AI, complex systems, gerophysics, and evolutionary biology. His work integrates lipidomics and comparative approaches to decode the molecular and systemic logic of longevity.
Dong Lu

Dong Lu

Research Fellow
Research Focus
Drug repurposing and discovery for reproductive longevity, leveraging C. elegans as a screening model and validating key hits and conserved mechanisms in mammalian systems to explore translational potential in improving female reproductive health and extending healthspan.
Zongmin Liu

Zongmin Liu

Research Fellow
Research Focus
Driven by curiosity about human aging, my research focuses on AI healthy longevity, exploring AI-powered approaches to discover longevity compounds and develop multi-omic aging biomarkers from blood, gut microbiome, and phenotypic data that could reveal aging patterns before they manifest. This work bridges computational drug discovery with experimental validation and clinical trial design, investigating how algorithms might transform aging from an inevitable decline into something we can predict, prevent, and modify.

PhD Students

Kamil Konrad Pabis

Kamil Konrad Pabis

PhD Student
Research Focus
Kamil Pabis, MSc from the University of Vienna and PhD student at NUS, researches combination therapies to extend mouse lifespan and controversial geroscience topics, with prior work on dwarf mice, iron homeostasis, mitochondrial disease, and aging bioinformatics in Austria, the UK, and Germany. He also hosts the Aging Science Podcast by VitaDAO and communicates science on Twitter as @Aging_Scientist.
Janjira Soh Gui Jiao

Janjira Soh Gui Jiao

PhD Student
Research Focus
My research interests focus on designing and managing clinical research projects, ensuring regulatory and ethical compliance, and advancing scientific communication through data analysis, manuscript writing, and outreach activities. I specialize in establishing clinical research laboratories, coordinating multidisciplinary teams, and developing standardized operating procedures to support high-quality clinical studies.
Sharah Mae Capinpin

Sharah Mae Capinpin

PhD Student, Research Assistant
Research Focus
My research interest lies in unraveling how circadian rhythm dysregulation can impact neural stem cell ageing and how pharmacological interventions targeting key components of circadian rhythm can potentially restore brain plasticity.
Weihan Huai

Weihan Huai

PhD Student
Research Focus
Prediction and discovery of novel geroprotectors and drug combinations; elucidating mechanisms of novel geroprotectors discovered.
Shivaanishaa Raventhiran

Shivaanishaa Raventhiran

PhD Student, Research Assistant
Research Focus
Use of supplements in mitigating aortic ageing and senescence, and investigating how supplements and repurposed drugs can improve health-span in aged mice.
Dinh Nhu Da Quynh

Dinh Nhu Da Quynh

PhD Student, Research Assistant
Research Focus
My research investigates the use of hypoimmunogenic mesenchymal stem cell (MSC) therapy as an anti-aging intervention to enhance muscle and brain health by applying this treatment to murine models of muscle injury and Alzheimer's disease (AD).
Lim Zhi Meng

Lim Zhi Meng

PhD Student, Research Associate
Research Focus
I am passionate about translation science, particularly in exploring how longevity compounds that are effective in laboratory models can be translated to humans and companions to meaningfully extend healthspan.
Ruslan Gumerov

Ruslan Gumerov

PhD Student
(Supervisor: Brian Kennedy, Jan Gruber)
Research Focus
I use computational biology and machine learning techniques to develop novel methodologies for altering human longevity. My research lies at the foundation of drug discovery, combining analysis of large-scale biological datasets with advanced algorithms to identify novel potential targets, pathways, and mechanisms of action in aging biology. The goal of this work is to help humanity gain more control over lifespan limits.

Research Associates

Avely Marjapuu

Avely Marjapuu

Research Associate
Research Focus
I'm passionate about digital health and bringing longevity research beyond the lab. As the Event and Business Lead, I organize conferences and host webinars on healthy longevity, creating spaces that connect researchers, industry experts and innovators.
Belinda Wang

Belinda Wang

Research Associate
Research Focus
With a background in psychology and mental health sciences, I'm especially curious about the interplay between physical and mental health. As Head of Wellbeing and Engagement for the Young Scientist Club, I support our vision to foster an inclusive research environment.

Research Assistants

Grace Keh Lay Yee

Grace Keh Lay Yee

Research Assistant
Research Focus
Building on her undergraduate work, Grace's research focuses on repurposing drugs for geroprotection, with an emphasis on identifying TFEB activators that can enhance autophagy to counter the age-related decline in macroautophagy.
Koh Ting Wei Kelvin

Koh Ting Wei Kelvin

Research Assistant
Research Focus
Specializes in procurement, safety protocols, and general laboratory maintenance to ensure smooth operations of research activities.

Collaborators

Vincenzo Sorrentino

Vincenzo Sorrentino

Assistant Professor
Research Focus
Biology of aging with a focus on the interconnection between mitochondrial homeostasis and proteostasis. Laboratory focuses on: 1. Biology of aging 2. Proteostasis 3. Mitochondria and NAD+ metabolism 4. Preclinical models of neuromuscular disease (e.g. C. elegans, cell lines, rodents)

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Jan Gruber

Jan Gruber

Associate Professor
Research Focus
Ageing, Age-dependent diseases, Interventions against Basic/Molecular Mechanisms of Ageing, C. elegans as a Model Organism, Role of Mitochondria and Free Radicals in Ageing and Age-dependent Diseases, Biomarkers of Oxidative Damage, Computational Biology, Evolution of ageing

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Fong Sheng

Fong Sheng

Consultant, Division of Geriatric Medicine, Ng Teng Fong General Hospital
Research Focus
Dr Fong Sheng focuses on biomarkers of aging and age-related diseases, developing clinical aging clocks (LinAge and LinAge2) for early detection and personalized interventions. He leads validation of LinAge2 across Singapore cohorts (SG70, LIFELONG), co-leads the Singapore Chinese Health Study and medical technology innovation at Ng Teng Fong General Hospital, and collaborates with NOVI Health to integrate aging clocks into clinical practice.

Hospital Webpage

Our Distinguished Alumni

Subha Subramanian
Former Research Associate
Azad Ganjendra Kumar
Former Senior Research Fellow
Daniel Teh Boon Loong
Former Senior Research Fellow
Chan Su Jing
Former Research Fellow
Mohammad Talaei Pashiri
Former Research Associate
Sii Toh Sim
Former Research Assistant
Jin Young Lee
Former Research Fellow
Indrik Wijaya
Former Research Assistant
Lok Ker Zhing
Former Research Fellow
Stephen Dinesh Raj
Former PhD student
Fann Yang-Wei David
Former Research Fellow
Shermila D/O N Kumar
Former Research Associate
Guo Huili
Former Senior Research Fellow
Lim Ying Ying
Former Lab Tech
Goncalves Barardo Diogo
Former Research Fellow
Djakim Latumalea
Former Research Associate
Denise Ong
Former Research Assistant