For the first time, Physiology celebrated a festive season virtually as a department. Thank you Chong Pey Rou, See Huimin, Cheng Mansi, Chong Oi Khuan, Heng Ye Yong, Nurul Arifah Binte Abdul Latiff, and Nurul Suhana Binte Ali Ahamed for organising Christmas celebration with fun virtual quizzes via zoom and for distributing cookies.

Associate Professor Saji Kumar Sreedharan was appointed as an Associate Editor of Oxford Open Science Journal.

Associate Professor Celestial Yap has been appointed to the Women in Science and Health (WISH) Executive Committee 2022-2023.

Research Assistant Professor Karen Crasta Carmelina has been selected as Associate Editor for the journal Frontiers in Aging (Neoplastic Pathologies of Aging section).

Research Associate Professor Jason Lee was appointed by the Quality and Safety Standards Committee (QSSC) under the purview of the Singapore Standards Council to serve as a Member in the Technical Committee to develop the National Code of Practice for Sports Safety.

Dr Yoon Jeehyun from Dr Derrick Ong’s lab has been awarded NUSMed B2B Collaboration Grant as a Principal Investigator.

Lecturer Ivan Low has been awarded the 2021 Faculty of Science Teaching Excellence Award. Hearty congratulations to Dr Low on this well-deserved recognition and his third successive award!

Research Assistant Professor Goh Jor Ming has been nominated and selected to receive this year's Tony A. Mobley International Distinguished Alumni Award for demonstrating outstanding personal and professional achievements in fostering the broad missions of public health.

Koh Shu Wen has been promoted to Laboratory Technologist LT2 with effect from January 1, 2022. Congratulations Shu Wen!

Lee Suk Yin Penny has been promoted to Laboratory Technologist LT3 with effect from January 1, 2022. Congratulations Penny!

Nurul Suhana Binte Ali Ahamed has been promoted to Laboratory Technologist LT3 with effect from January 1, 2022. Congratulations Suhana!

Research Associate Professor Jason Lee was featured in MEDSPRESSO and The Straits Times for his team's contribution to a new indicator that assessed the links between heat and exercise.
Feature in MEDSPRESSO
Full Article in The Straits Times

Research Associate Professor Jason Lee was featured in Third Spacing Podcast Episode 35. "How does heat impact our wellbeing? " on 30 October 2021.
Feature in Third Spacing Podcast

Professor Shazib Pervaiz was in the organizing committee of Frontiers in Cancer Science 2021 on 1-3 November 2021.
Conference Flyer

Professor Shazib Pervaiz successfully organized Mitochondria, Apoptosis & Cancer (MAC 2021) virtual symposium on 25-28 November 2021. Hsin Yao Chiu, Eu Jie Qing and Prof Pervaiz delivered talks at MAC 2021. Special thanks to Nurulhuda Mohd Nassir for administrative and logistics arrangement; and Nusrah Binte Anzi, Cheng Man Si, Koh Kang Sheing Phoebe and Nurul Suhana Binte Ali Ahamed for webinar technical support.
Program Booklet

Assistant Professor Andrew Tan delivered Continuing Education and Training (CET) course, Beginning Artificial Intelligence Through Neuroscience on 2 & 9 October 2021.

Lecturer Ivan Low and Research Associate Professor Jason Lee successfully delivered "Occupational Periodisation & Heat Stress Management" CET on 17-19 November 2021. Special thanks to Ngian Meixing, Cheryl, Lim Hong Meng, Koh Shu Wen, Wong Hooi Ling, Nurul Suhana Binte Ali Ahamed, Uma Thambiayah, Chong Oi Khuan, and Koh Kang Sheing Phoebe for the excellent administrative and logistics support!

Research Associate Professor Jason Lee successfully organized ILSI Symposium on Optimizing Health, Wellness and Human Potential on 24-25 November 2021. Special thanks to Nurul Suhana Binte Ali Ahamed and Koh Kang Sheing Phoebe for logistics support.
Symposium website

Associate Professor Chen Zhi Xiong has been invited as a guest speaker to deliver Dr. Domingo Ampil Memorial Lecture at Philippine Society of Anatomists, Inc. - Virtual Annual Convention 2021 "Reorienting the Medical Curriculum Towards Training the Primary Health Care Physician and Its Implications in the Teaching of Anatomy" on 30 November 2021.

Associate Professor Chen Zhi Xiong has been invited as a guest speaker at 2021 Webinar for Medical Education during COVID-19 in East Asia on 24 November 2021.
Webinar website

Associate Professor Chen Zhi Xiong has been invited as a guest panelist and guest speaker at Young Health Ambassadors' Programme on 27 November 2021.
Programme website

Research Assistant Professor Karen Crasta Carmelina has been invited as a conference speaker. The 94th Annual Meeting of the Japanese Biochemical Society, Nov 3rd-5th 2021, Yokohama, Japan (2021). Session 2S07e, New trends in cellular senescence, on 4 November 2021.
Conference website

Assistant Professor John Jia En Chua has been invited as an invited speaker (oral presentation) at Abcam Spotlight on Neuroscience - Neurodevelopmental Disorders on 20 October 2021.
Webinar website

Dr Qu Yinghua, a research fellow from Dr John Chua's lab, has been invited to give a flash talk at Society for Neuroscience (Singapore Chapter) meeting 2021 on 10 December 2021.

Saravanan Gunaseelan, a graduate student from Dr John Chua's lab, has been invited to give a long talk at Society for Neuroscience (Singapore Chapter) meeting 2021 on 10 December 2021.

NUS-CMU Joint Symposium 2022
24-25 February 2022
Organizing Chairs: Dr Derrick Ong, Dr Ling Shuo-Chien, Dr Tsai Shih-Yin, Dr Takaomi Sanda. Advisor: Prof Reshma Taneja
Organizing Committee Members: Ms Tan Shu Yi, Ms Koh Shu Wen, Ms Nurul Arifah Binte Abdul Latiff, Mr Hong Jian Hui Cedric, Ms Koh Kang Sheing Phoebe

EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma
Alamelu Nachiyappan, Joshua Ling Jun Soon, Huey Jin Lim, Victor Km Lee, Reshma Taneja
J Pathol. 2021 Dec 12. doi: 10.1002/path.5848.
Abstract

Crosstalk Between Inflammatory Signaling and Methylation in Cancer
Dipanwita Das, Nandini Karthik, Reshma Taneja
Front Cell Dev Biol. 2021 Nov 24;9:756458. doi: 10.3389/fcell.2021.756458. eCollection 2021.
Full Text

Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis
Rene Rauschmeier, Annika Reinhardt, Charlotte Gustafsson, Vassilis Glaros, Artem V Artemov, Josefine Dunst, Reshma Taneja, Igor Adameyko, Robert Mansson, Meinrad Busslinger, Taras Kreslavsky
J Exp Med. 2022 Feb 7;219(2):e20211406. doi: 10.1084/jem.20211406. Epub 2021 Dec 17.
Full Text

Neurokinin receptor mechanisms in forebrain medial septum modulate nociception in the formalin model of inflammatory pain
Si Yun Ng, Mohammed Zacky Ariffin and Sanjay Khanna
Scientific Reports, volume 11, Article number: 24358 (2021). doi: 10.1038/s41598-021-03661-6
Full Text

Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
Brittney Joy-Anne Foo, Jie Qing Eu, Jayshree L Hirpara, Shazib Pervaiz
Oxid Med Cell Longev. 2021 Nov 3;2021:1341604. doi: 10.1155/2021/1341604. eCollection 2021.
Full Text

TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3
Deepika Raman, Patricia Tay, Jayshree L Hirpara, Dan Liu, Shazib Pervaiz
Redox Biol. 2021 Nov 20;48:102193. doi: 10.1016/j.redox.2021.102193.
Abstract

Identification of a novel catalytic inhibitor of topoisomerase II alpha that engages distinct mechanisms in p53 wt or p53 -/- cells to trigger G2/M arrest and senescence
Soo Fern Lee, Jayshree L Hirpara, Jianhua Qu, Sanjiv K Yadav, Karishma Sachaphibulkij, Shazib Pervaiz
Cancer Lett. 2021 Nov 26;526:284-303. doi: 10.1016/j.canlet.2021.11.025.
Abstract

The redox-senescence axis and its therapeutic targeting
Natalie YL. Ngoi, Angeline QX. Liew, Stephen J.F. Chong, Matthew S. Davids, Marie-Veronique Clement, Shazib Pervaiz
Redox Biology, Volume 45, 102032. DOI: 10.1016/j.redox.2021.102032
Full Text

LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer: Erratum
Biao Zheng, Jianhua Qu, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Zilong Yan, Yicui Piao6, Peng Liu1, Nan Sheng, Daiki Eguchi, Takao Ohtsuka, Kazuhiro Mizumoto, Zhong Liu, Shazib Pervaiz, Peng Gong, Masafumi Nakamura
Theranostics 2021; 11(20):10171-10172. doi:10.7150/thno.68023
Abstract

The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
Rafhanah Banu Bte Abdul Razar, Yinghua Qu, Saravanan Gunaseelan, John Jia En Chua
Neural Regen Res. 2022 Jun;17(6):1165-1171. doi: 10.4103/1673-5374.327327.
Full Text

Changes in energy balance, body composition, metabolic profile and physical performance in a 62-day Army Ranger training in a hot-humid environment
Linda S H Gan, Priscilla W P Fan, Junren Zhang, Heinrich W Nolte, Karl E Friedl, Bradley C Nindl, Jason K W Lee
J Sci Med Sport. 2022 Jan;25(1):89-94. doi: 10.1016/j.jsams.2021.08.005.
Full Text

Palatable Flavoured Fluids without Carbohydrates and Electrolytes Do Not Enhance Voluntary Fluid Consumption in Male Collegiate Basketball Players in the Heat
Bernadette Cherianne Taim, Haresh T. Suppiah, Jericho Wee, Marcus Lee, Jason K. W. Lee and Michael Chia
Nutrients 2021, 13(12), 4197. DOI: 10.3390/nu13124197
Full Text

The 2021 Report of The Lancet Countdown on Health and Climate Change
Samuel H Gunther, Stella Hartinger, Kehan He, Clare Heaviside, Jeremy Hess, Shih-Che Hsu, Prof Slava Jankin, Marcia P Jimenez, Prof Ilan Kelman, Gregor Kiesewetter, Prof Patrick L Kinney, Prof Tord Kjellstrom, Prof Dominic Kniveton, Jason K W Lee, Bruno Lemke, Prof Yang Liu, Zhao Liu, Melissa Lott, Rachel Lowe, Prof Jaime Martinez-Urtaza, Prof Mark Maslin, Lucy McAllister, Celia McMichael, Zhifu Mi, James Milner, Kelton Minor, Nahid Mohajeri, Prof Maziar Moradi-Lakeh, Prof Karyn Morrissey, Prof Simon Munzert, Kris A Murray, Tara Neville, Prof Maria Nilsson, Nick Obradovich, Maquins Odhiambo Sewe, Prof Tadj Oreszczyn, Matthias Otto, Fereidoon Owfi, Olivia Pearman, David Pencheon, Mahnaz Rabbaniha, Prof Elizabeth Robinson, Prof Joacim Rocklov, Renee N Salas, Prof Jan C Semenza, Jodi Sherman, Liuhua Shi, Marco Springmann, Prof Meisam Tabatabaei, Jonathon Taylor, Joaquin Trinanes, Joy Shumake-Guillemot, Bryan Vu, Fabian Wagner, Prof Paul Wilkinson, Matthew Winning, Marisol Yglesias, Shihui Zhang, Prof Peng Gong, Prof Hugh Montgomery, Prof Anthony Costello, Prof Ian Hamilton
The Lancet, Volume 398, ISSUE 10311, P1619-1662, October 30, 2021. DOI: 10.1016/S0140-6736(21)01787-6
Full Text

Hydration Status and Fluid Replacement Strategies of High-Performance Adolescent Athletes: An Application of Machine Learning to Distinguish Hydration Characteristics
Haresh T. Suppiah, Ee Ling Ng, Jericho Wee, Bernadette Cherianne Taim, Minh Huynh, Paul B. Gastin, Michael Chia, Chee Yong Low and Jason K. W. Lee
Nutrients 2021, 13(11), 4073. DOI: 10.3390/nu13114073
Full Text

Sensory Perception of an oral rehydration solution during exercise in the heat
Olivia Kitson, Kay Rutherfurd-Markwick, Andrew Foskett, Jason Kai Wei Lee, Charles Diako, Marie Wong and Ajmol Ali
Nutrients 2021,13, 3313. DOI: 10.3390/nu13103313
Full Text

Breaking the vicious circle: Extrachromosomal circular DNA as an emerging player in tumour evolution
Matius Robert, Karen Crasta
Semin Cell Dev Biol. 2021 Nov 29;S1084-9521(21)00291-3. doi: 10.1016/j.semcdb.2021.11.015. Online ahead of print.
Abstract

Chromothripsis: A shattered chromosome in the spotlight
Karen Crasta
Semin Cell Dev Biol. 2021 Nov 25;S1084-9521(21)00303-7. doi: 10.1016/j.semcdb.2021.11.021. Online ahead of print.
Abstract

Educational dialogue on public perception of nuclear radiation
Varsha Hande, Karthik Prathaban & M. Prakash Hande
International Journal of Radiation Biology, in press. DOI: 10.1080/09553002.2022.2009147
Abstract

Novel Autoantibodies in Idiopathic Small Fiber Neuropathy
Amanda C. Y. Chan, Hiu Yi Wong, Yao Feng Chong, Poh San Lai, Hock Luen Teoh, Alison Y. Y. Ng, Jennifer H. M. Hung, Yee Cheun Chan, Kay W. P. Ng, Joy Vijayan, Jonathan J. Y. Ong, Bharatendu Chandra, Chi Hsien Tan, Nurul H. Rutt, Ti Myen Tan, Nur Hafiza Ismail, Einar Wilder-Smith, Herbert Schwarz, Hyungwon Choi, Vijay K. Sharma, Anselm Mak
Annals of Neurology, DOI: 10.1002/ana.26268
Full Text

Dendritic cell therapy with CD137L-DC-EBV-VAX in locally recurrent or metastatic nasopharyngeal carcinoma is safe and confers clinical benefit
Emily Nickles, Bhushan Dharmadhikari, Li Yating, Robert J Walsh, Liang Piu Koh, Michelle Poon, Lip Kun Tan, Ling-Zhi Wang, Yvonne Ang, Yugarajah Asokumaran, Wan Qin Chong, Yiqing Huang, Kwok Seng Loh, Joshua Tay, Ross Soo, Mickey Koh, Liam Pock Ho, Marieta Chan, Madelaine Niam, Melissa Soh, Yen Hoon Luah, Chwee Ming Lim, Nivashini Kaliaperumal, Veonice B Au, Najwa Binte Said Nasir Talib, Reina Sng, John E Connolly, Boon Cher Goh, Herbert Schwarz
Cancer Immunol Immunother. 2021 Oct 18. doi: 10.1007/s00262-021-03075-3.
Abstract

No crossreactivity of anti-SARS-CoV-2 spike protein antibodies with Syncytin-1
Mukul Prasad, Jia Le Lin, Yue Gu, Rashi Gupta, Paul Macary, Herbert Schwarz
Cell Mol Immunol. 2021 Nov;18(11):2566-2568. doi: 10.1038/s41423-021-00773-x.
Full Text

B7-H7 Is Inducible on T Cells to Regulate Their Immune Response and Serves as a Marker for Exhaustion
Khang Luu, Herbert Schwarz, and Andreas Lundqvist
Front Immunol. 2021; 12: 682627. doi: 10.3389/fimmu.2021.682627
Full Text

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L Wickstrom, Andreas Lundqvist, Herbert Schwarz
Cells. 2021 Feb 9;10(2):353. doi: 10.3390/cells10020353.
Abstract

Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma
Rachel L Y Wong, Megan R E Wong, Chik Hong Kuick, Seyed Ehsan Saffari, Meng Kang Wong, Sheng Hui Tan, Khurshid Merchant, Kenneth T E Chang, Matan Thangavelu, Giridharan Periyasamy, Zhi Xiong Chen, Prasad Iyer, Enrica E K Tan, Shui Yen Soh, N Gopalakrishna Iyer, Qiao Fan, Amos H P Loh
Front Oncol. 2021 Oct 14;11:709525. doi: 10.3389/fonc.2021.709525. eCollection 2021.
Full Text

Plk1 in Asthma - Ready for Primetime?
John Kit Chung Tam, Thai Tran
Am J Respir Cell Mol Biol. 2021 Nov 8. doi: 10.1165/rcmb.2021-0425ED.
Full Text

Tetraspanins: Host Factors in Viral Infections
ChihSheng New, Zhao-Yong Lee, Kai Sen Tan, Amanda Huee-Ping Wong, De Yun Wang, Thai Tran
Int J Mol Sci. 2021 Oct 27;22(21):11609. doi: 10.3390/ijms222111609.
Full Text

Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer's disease
Sheeja Navakkode, Jessica Ruth Gaunt, Maria Vazquez Pavon, Vibhavari Aysha Bansal, Riya Prasad Abraham, Yee Song Chong, Toh Hean Ch'ng, Sreedharan Sajikumar
Aging Cell. 2021 Nov 18;e13502. doi: 10.1111/acel.13502.
Abstract

Deciphering nanoparticle trafficking into glioblastomas uncovers an augmented antitumor effect of metronomic chemotherapy
Melgious Jin Yan Ang, Jeehyun Yoon, Mingzhu Zhou, Han-Lin Wei, Yi Yiing Goh, Zhenglin Li, Jia Feng, Haifang Wang, Qianqian Su, Derrick Sek Tong Ong, Xiaogang Liu
Adv Mater. 2021 Nov 2;e2106194. DOI: 10.1002/adma.202106194.
Abstract

Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives
Shujian Ong, Larry Loo, Marion Pang, Russell Tan, Yao Teng, Xuanming Lou, Sze Khen Chin, Mihir Yogesh Naik, Hanry Yu
Biomaterials. Volume 277, October 2021, 121107. DOI: /10.1016/j.biomaterials.2021.121107
Abstract

Metaplastic reinforcement of long-term potentiation in hippocampal area CA2 by cholinergic receptor activation
Amrita Benoy, Mohammad Zaki Bin Ibrahim, Thomas Behnisch, Sreedharan Sajikumar
J Neurosci. 2021 Sep 24;JN-RM-2885-20. DOI: 10.1523/JNEUROSCI.2885-20.2021.
Abstract

Inactive variants of death receptor p75 NTR reduce Alzheimer’s neuropathology by interfering with APP internalization
Chenju Yi, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar, Carlos F Ibáñez
EMBO J. 2021 Sep 1;40(17):e109067. DOI: 10.15252/embj.2021109067.
Abstract

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