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| Member, NUHS Women in Science and Healthcare (WISH) Executive Council |
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Member, National Physical Activity Guidelines Advisory Committee, Health Promotion Board and Sport Singapore |
Research Assistant Professor Crasta Karen Carmelina has been appointed as NUHS Women in Science and Healthcare (WISH) Executive Council Member.
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Research Associate Professor Jason Lee has been appointed as member of National Physical Activity Guidelines Advisory Committee, Health Promotion Board and Sport Singapore, Ministry of Health and Ministry of Culture, Community and Youth. |
| Member, NUS Faculty Teaching Excellence Committee (FTEC) |
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Director, International Association of Medical Science Educators (IAMSE) Board of Directors |
Senior Lecturer Chen Zhi Xiong has been appointed as member of the NUS Faculty Teaching Excellence Committee (FTEC).
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Senior Lecturer Chen Zhi Xiong has been appointed as director on International Association of Medical Science Educators (IAMSE) Board of Directors. |
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| Gold Research Award: Swee Liew-Wadsworth Research Publication Awards [1 Jan 2020 – 31 Dec 2020]
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| Silver Research Award: Swee Liew-Wadsworth Research Publication Awards [1 Jan 2020 – 31 Dec 2020] |
Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, Valentin R, Herbaux C, Collins M, Low ICC, Loh T, Davids M, Pervaiz S
Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism
Nucleic Acids Research, 2020 Dec 16;48(22):12727-12745
Peng AYT*, Agrawal I*, Ho WY*, Yen YC, Pinter AJ, Liu J, Phua QXC, Koh KB, Chang JC, Sanford E, Man JHK, Wong P, Gutmann DH, Tucker-Kellogg G, Ling SC
Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction
Proc Natl Acad Sci U S A, 2020 Nov 17; 117(46):29101-29112
*First Co-Authors
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Raman D, Chong SJF, Iskandar K, Hirpara JL, Pervaiz S
Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc
Redox Biol, 2020 Jul; 34:101587
Hirpara JL, Subramaniam K, Bellot G, Qu J, Seah S, Loh T, Tucker-Kellogg L, Clement MV and Pervaiz S
Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
Redox Biol, 2020 Feb; 30:101403
Dasgupta A, Lim YJ, Kumar K, Baby N, Pang KLK, Benoy A, Behnisch T, Sajikumar S
Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2
eLife, 2020 Apr 20;9:e55344
Pal A, Leung JY, Ang GCK, Rao VK, Pignata L, Lim HJ, Hebrard M, Chang KT, Lee VK, Guccione E, Taneja R
EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma
eLife, 2020 Nov 30;9:e57683
Baby N, Alagappan N, Dheen ST, Sajikumar S
MicroRNA‐134‐5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ (1–42)‐induced model of Alzheimer’s disease
Aging Cell, 2020 Jan;19(1):e13046
Zeng Q, Soe YM, Lim Y, Sobota RM, Schwarz H
CD137 ligand interacts with CD32a to trigger reverse CD137 ligand signalling
Cell Mol Immunol, 2020 Nov;17(11):1188-1189
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| A/Prof Jason Lee featured in MEDSPRESSO and NUS News |
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A/Prof Jason Lee featured in article published by Thomson Reuters Foundation |
Research Associate Professor Jason Lee was featured in MEDSPRESSO and NUS News for his research work on tackling heat stress.
Feature in MEDSPRESSO
Full Article in NUS News
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Research Associate Professor Jason Lee was featured in an article published by Thomson Reuters Foundation for his study on effects of rising heat on vulnerable workers in Southeast Asia.
Full Article
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| A/Prof Jason Lee featured in The Straits Times |
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A/Prof Jason Lee featured in Medflix on YouTube |
Research Associate Professor Jason Lee was featured in The Straits Times for his opinion on how current Physical Employment Standards (PES) can be better matched with NSmen's abilities.
The Straits Times Article
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Research Associate Professor Jason Lee was featured in Medflix, NUS Medicine for his sharing on heat stress management strategies.
Full Video
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| Beginning Artificial Intelligence Through Neuroscience |
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Occupational Periodisation & Heat Stress Management |
Assistant Professor Andrew Tan has successfully launched Physiology's first Continuing Education and Training (CET) course, Beginning Artificial Intelligence Through Neuroscience.
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Research Associate Professor Jason Lee and Lecturer Ivan Low will be launching Continuing Education and Training (CET) course, Occupational Periodisation & Heat Stress Management, in July 2021.
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| Asia Pacific Medical Education Conference 2021 (APMEC 2021) |
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Associate Professor Koh Dow Rhoon was in the organizing committee of APMEC 2021 held in 22-24 January 2021. A/Prof Koh Dow Rhoon, A/Prof Celestial Yap, and Dr Chen Zhi Xiong, gave talks and chaired session at this conference.
APMEC 2021
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Pulsed electromagnetic fields synergize with graphene to enhance dental pulp stem cell-derived neurogenesis by selectively targeting TRPC1 channels
TT Madanagopal, YK Tai, SH Lim, CHH Fong, T Cao, V Rosa, A Franco-Obregón
Eur Cell Mater. 2021 Mar 1;41:216-232. doi: 10.22203/eCM.v041a16.
Abstract
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Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides
Huang, Hua; Tay, Shermaine Huiping; Ng, Winanto; Ng, Shi Yan; Soong, Tuck Wah
PAIN, in press. doi: 10.1097/j.pain.0000000000002216
Abstract
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ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation
Jin-Hui Hor, Munirah Mohamad Santosa, Valerie Jing Wen Lim, Beatrice Xuan Ho, Amy Taylor, Zi Jian Khong, John Ravits, Yong Fan, Yih-Cherng Liou, Boon-Seng Soh, Shi-Yan Ng
Cell Death Differ. 2020 Nov 12. doi: 10.1038/s41418-020-00664-0. Online ahead of print.
Abstract
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CD137 / CD137 ligand signalling regulates the immune balance: A potential target for novel immunotherapy of autoimmune diseases
Hiu Yi Wong, Herbert Schwarz
J Autoimmun. 2020 Aug;112:102499. doi: 10.1016/j.jaut.2020.102499. Epub 2020 Jun 4.
Abstract
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The role of trogocytosis in immune surveillance of Hodgkin lymphoma
Qun Zeng, Herbert Schwarz
Oncoimmunology. 2020 Jun 17;9(1):1781334. doi: 10.1080/2162402X.2020.1781334.
Abstract
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CD137 Ligand-CD137 Interaction is Required For Inflammasome-Associated Brain Injury Following Ischemic Stroke
David Y Fann, Emily Pauline Nickles, Luting Poh, Vismitha Rajeev, Sharmelee Selvaraji, Herbert Schwarz, Thiruma V Arumugam
Neuromolecular Med. 2020 Dec;22(4):474-483. doi: 10.1007/s12017-020-08623-1. Epub 2020 Oct 19.
Abstract
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Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis
Binbin Wang, Gregory Lucien Bellot, Kartini Iskandar, Tsung Wen Chong, Fera Yiqian Goh, June Jingyi Tai, Herbert Schwarz, Siew Cheng Wong, Shazib Pervaiz
Sci Rep. 2020 Nov 2;10(1):18837. doi: 10.1038/s41598-020-74578-9.
Abstract
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Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
Hiu Yi Wong, Ankshita Prasad, Shu Uin Gan, John Jia En Chua, Herbert Schwarz
Front Immunol. 2020 Nov 6;11:571964. doi: 10.3389/fimmu.2020.571964. eCollection 2020.
Abstract
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Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development
Saravanan Gunaseelan, Ziyin Wang, Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Rafhanah Banu Bte Abdul Razar, Sumitra Srimasorn, Wei-Yi Ong, Kah-Leong Lim, John Jia En Chua
Hum Mol Genet. 2021 Jan 4;ddaa281. doi: 10.1093/hmg/ddaa281. Online ahead of print.
Abstract
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Slow Gait, Subjective Cognitive Decline and Motoric Cognitive RISK Syndrome: Prevalence and Associated Factors in Community Dwelling Older Adults
Reshma A Merchant, J Goh, Y H Chan, J Y Lim, B Vellas
J Nutr Health Aging. 2021;25(1):48-56. doi: 10.1007/s12603-020-1525-y.
Abstract
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A 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats
Venkatesh Gopalan, Jadegoud Yaligar, Navin Michael, Kavita Kaur, Rengaraj Anantharaj, Sanjay Kumar Verma, Suresh Anand Sadananthan, Giang Thi Thu Le, Jorming Goh, S Sendhil Velan
Biosci Rep. 2021 Jan 29;41(1):BSR20201707. doi: 10.1042/BSR20201707.
Abstract
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Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia
Colin Harper, Venkatesh Gopalan, Jorming Goh
J Transl Med. 2021 Feb 16;19(1):71. doi: 10.1186/s12967-021-02737-1.
Abstract
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Inactive variants of death receptor p75 NTR reduce Alzheimer's neuropathology by interfering with APP internalization
Chenju Yi, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar, Carlos F Ibáñez
EMBO J. 2021 Jan 15;40(2):e104450. doi: 10.15252/embj.2020104450. Epub 2020 Dec 1.
Abstract
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Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor
Lik-Wei Wong, Yee Song Chong, Wei Lin, Lilian Kisiswa, Eunice Sim, Carlos F Ibáñez, Sreedharan Sajikumar
Aging Cell. 2021 Feb;20(2):e13305. doi: 10.1111/acel.13305. Epub 2021 Jan 15.
Abstract
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Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting
Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh, Herbert Schwarz
Oncoimmunology. 2021 Feb 4;10(1):1877459. doi: 10.1080/2162402X.2021.1877459.
Abstract
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Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L Wickström, Andreas Lundqvist, Herbert Schwarz
Cells. 2021 Feb 9;10(2):353. doi: 10.3390/cells10020353.
Abstract
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TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells
Kae-Jiun Chang, Ira Agrawal, Anna Vainshtein, Wan Yun Ho, Wendy Xin, Greg Tucker-Kellogg, Keiichiro Susuki, Elior Peles, Shuo-Chien Ling, Jonah R Chan
Elife. 2021 Mar 10;10:e64456. doi: 10.7554/eLife.64456.
Full Text
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Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits
Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, Emma Sanford, Wei-Tang Chang, Kenneth Lim, Jolynn Ong, Bernice Siu Yan Tan, Aung Aung Kywe Moe, Regina Yu, Peiyan Wong, Greg Tucker-Kellogg, Edward Koo, Kai-Hsiang Chuang, Shuo-Chien Ling
Acta Neuropathol Commun. 2021 Jan 6;9(1):9. doi: 10.1186/s40478-020-01111-4.
Abstract
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Assessment of dehydration using body mass changes of elite marathoners in the tropics
Xiang Ren Tan, Ivan Cherh Chiet Low, Chris Byrne, Ru Wang, Jason Kai Wei Lee
Journal of Science and Medicine in Sport. Available online 31 January 2021. doi: 10.1016/j.jsams.2021.01.008
Abstract
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Managing Heat Stress in the Workplace
Jason Lee, Edward Lo Hong Yee, Alexander Gorny, Ng Yih Yng, Joshua Wong, Cheong Wee Kiong, Don Wilson Paua Boon Leng, Foo May Ling, Kenneth Choy, Lucy Leong,Edison J Loh
Workplace Safety and Health Guidelines. doi: 10.13140/RG.2.2.22210.81604.
Full Text
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FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development
Jie Yin Chua, Shi Jun Ng, Oleksandr Yagensky, Erich E Wanker and John Jia En Chua
eNeuro 26 March 2021, ENEURO.0193-20.2021. doi: 10.1523/ENEURO.0193-20.2021
Abstract
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NUS-CMU Joint Symposium 2021
23-24 September 2021
Organizing Chairs: Dr Derrick Ong, Dr Ling Shuo-Chien, Dr Tsai Shih-Yin, Dr Takaomi Sanda. Advisor: Prof Reshma Taneja
Organizing Committee Members: Ms Tan Shu Yi, Ms Koh Shu Wen, Mr Hong Jian Hui Cedric, Ms Koh Kang Sheing Phoebe
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