TANEJA LAB PUBLICATIONS
Selected Publications
Das D, Leung JY, Balamurugan S, Tergaonkar V, Loh A, and Taneja R. (2024). BRD4 isoforms have distinct roles in tumor progression and metastasis in rhabdomyosarcoma. EMBO Reports in press
Luke N, Taneja R, Ban K, Samarasekera D, Yap CT (2023). Large language models (ChatGPT) in medical education: Embrace or abjure? The Asia Pacific Scholar 8:50-52
Hamashima K, Wong KW, Tsz SW, Taneja R, Li H, Loh J. (2023) Single-cell multiomic mapping of m6A methylome and transcriptome in native populations of cells with sc-m6A-CT. Molecular Cell 25:S1097-2765(23)00649-4.
Cho MZ, Lee H-G, Yoon J-W, Kim G-R, Koo J-H, Taneja R, Edelson B, Lee YJ, Choi JM. (2023). Single-cell transcriptomic analysis identifies heterogenous memory-phenotype CD4 T cells exacerbating autoimmune neuroinflammation. Experimental & Molecular Medicine doi: 10.1038/s12276-023-00995-1
Yi Y, Zeng YY, Hamashima K, Sam TW, Tan JR, Warrier T, Phua JX, Taneja R, Liou Y-C, Li H, Xu J, Loh Y-H. (2023). Ribosomal proteins regulate 2 cell stage transcriptome in mouse embryonic stem cell. Stem Cell Reports 18(2):463-474
Karthik N, Lee J, Soon J, Chiu HY, Loh A, Ong D, Tam WL, Taneja R. (2023). Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma.J Pathology 259(3):342-356
Rao VK, Das D and Taneja R. (2022). Cancer Cachexia: Signalling and Transcriptional Regulation of Muscle Catabolic Genes. Cancers 14(17):4258
Yang ND, Das D, Shankar SR, Goy PA, Guccione E and Taneja R. (2022). An interplay between Brd4 and G9a regulates skeletal myogenesis. Front Cell Dev Biol 10:978931
Ang CKG, Gupta A, Yap XLS, Surana U and Taneja R. (2022). Potential therapeutics targeting upstream regulators and interactors of EHMT1/2. Cancers 14(12):2855
Tan H, Lu G, Cho Y-L, Dong H, Wang L, Auginia N, Chan C, Kappei D, Taneja R, Ling SC, Shao H, Tsai S-Y, Ding W-X, Shen HM (2022). A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nature Communications, 13(1):3720
Chen J, Zou L, Grinchuk O, GLu G, Fang L, XBi X, Ong DST, Taneja R, Ong CN, and Shen HM. (2022). PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation Cell Discovery 8(1):52.
Chiu HY, Loh A and Taneja R. (2022). MCU dependent mitochondrial calcium uptake regulates TGFb signaling and tumor progression in embryonal rhabdomyosarcoma. Cell Death and Disease 13:419.
Salmon A , Jarjour N, Esaulova E, Williams C, Shavkunov A, Ward J, Dunckelman A, Taneja R, Edelson B, Gubin M. (2022). Tumor BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint-Therapy Efficacy. Cancer Immunology Research doi: 10.1158/2326-6066.CIR-21-0129
Nachiyappan A, Gupta N and Taneja R. (2022) EHMT1/EHMT2 in EMT, Cancer Stemness and Drug Resistance: Emerging Evidence and Mechanisms. FEBS J 289:1329-1351.
Nachiyappan A, Soon J, Lim HJ, Lee VKM, and Taneja R (2022). EHMT1 promotes tumor progression and regulates ALDH1A1 expression in alveolar rhabdomyosarcoma. J Pathology 256:349-362.
Rauschmeier R, Reinhardt A, Gustafsson C, Glaros V, Artemov AV, Taneja R, Adameyko I, Månsson R, Busslinger M and Kreslavsky T. (2022). Bhlhe40 function in activated B cells and TFH cells restrains the GC reaction and prevent lymphomagenesis. J Experimental Medicine 219:e20211406
Das D, Karthik N, and Taneja R (2021) Cross talk between inflammatory signaling and methylation in cancer. Frontiers in Cell and Developmental Biology 9:756458.
Karthik N and Taneja R. (2021). Histone variants in skeletal myogenesis. Epigenetics (2021) 16, 243–262
Pal A, Leung JY, Ang GCK, Rao VK, Pignata L, Lim HJ, Hebrard M, Chang KT, Lee VKM, Guccione E, and Taneja R (2020). EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma. eLife 2020;9:e57683.
Leung JY, Chia K, Ong DST and Taneja R (2020). Interweaving tumor heterogeneity in the cancer epigenetic-metabolic axis. Antioxidants and Redox Signalling 33:946-965 (invited review)
Piper C, Zhou V, Komorowski R, Szabo A, Vincent B, Serody J, Alegre ML, Edelson BT, Taneja R and Drobyski WR. (2020). Pathogenic Bhlhe40+ GM-CSF+ CD4+ T Cells Promote Indirect Alloantigen Presentation in the GI Tract during GVHD. Blood 135: 568-681
Chiu HY, Tay E, Dong DST, Taneja R. (2020). Mitochondrial dysfunction at the centre of cancer therapy. Antioxidants and Redox Signalling. 32:309-330
Jarjour NN, Bradstreet TR, Schwarzkopf EA, Cook ME, Lai CW, Huang SC, Taneja R, Stappenbeck T, Dyken JV, Urban JF, Edelson BT. (2020). Bhlhe40 promotes T(H)2 cell mediated antihelminth immunity and reveals cooperative CSF2RB family cytokines. J Immunology 204:923-932
Karthigeyan D, Bose A, Boopathi R, Rao VJ, Shima H, Bharathy N, Igarashi K, Taneja R, Kundu Kundu T. (2020) Aurora kinase A mediated phosphorylation of mPOU is critical for skeletal muscle differentiation. J Biochemistry 167: 195-201
Yap JYY, Kit TY, Fröhlich J, Pelczar P, Beyer C, Casarosa M, Purnamawati K, Fong CHH, Cerrato CP, Ramanan S, Yin JN, Bharathy, N, Palanichamy Kala M, Richards PJ, Mirsaidi A, Xuan TGR, Taneja R, Egli M, Kozak KW, Ferguson SJ, Aguzzi A, Krawczy KK, Monici M, Drum C, Lee CN, Franco-Obregón A. (2019) Ambient and exogenous magnetic fields modulate myogenesis by targeting TRPC1. FASEB J 33(11):12853-12872
Li C, Zhu B, Son Y, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins J, Siska P, Vincent B, Prakash YS, Piekert T, Edelson B, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, and Sun J. (2019) The transcription factor Bhlhe40 programs mitochondrial regulation of resident CD8+ T cell fitness and functionality. Immunity 51(3):491-507
Rauschmeier R, Gustafsson C, Gonzalez N, Tortola L, Subramanian S, Taneja R, Rossner MJ, Sieweke M, Månsson R, Busslinger M, and Kreslavsky T. (2019) Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity. EMBO J 38(19):e101233 doi: 10.15252/embj.2018101233
Jarjour NN, Schwarzkopf EA, Bradstreet TR, Shchukina I, Lin CC, Huang SC, Lai CW, Cook ME, Taneja R, Stappenbeck T, Randolph GJ, Artymov MN, Urban JF, Edelson BT. (2019). Bhlhe40 mediates tissue specific control of macrophage proliferation in homeostasis and type 2 immunity. Nature Immunology 20:687-700
Srinivasan S, Shankar SR, Wang Y, Taneja R. (2019) SUMOylation of G9a regulates its function as an activator of myoblast proliferation. Cell Death and Disease 10(3):250.
Bhat AV, Palanichamy Kala M, Rao VK, Pignata L, Lim HJ, Suriyamurthy S, Chang K, Min VK, Guccione E and Taneja R. (2019) Epigenetic regulation of the PTEN/AKT/RAC1 axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma. Cancer Research 79:2232-2243
Pal A, Chiu HY, Taneja R. (2019). Genetics, epigenetics and redox homeostasis in rhabdomyosarcoma: Emerging targets and therapeutics. Redox Biology 25 (2019):101124.
Bhat A, Hora S, Pal A, Jha S, Taneja R (2018). Stressing the (Epi)genome: dealing with reactive oxygen species in cancer. Antioxidants and Redox Signaling 29:1273-1292.
Numata A, Kwok HS, Kawasaki A, Li J, Benoukraf T, Zhou QL, Kerry J, Benoukraf T, Barraria D, Li F, Ballabio E, Tapia M, Hog HQ, Deshpande A, Welner, RS, Yang H, Delwel R, Milne T, Taneja R*, Tenen DG*. (2018). The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 Acute Myelogenous Leukemia. Nature Communications 9:1622. *co-corresponding.
Choi MH, Palanichamy Kala M, Ow JR, Rao VK, Suriyamurthy S and Taneja R (2018). GLP modulates heterochromatin clustering and myogenic differentiation by repressing MeCP2. J Molecular Cell Biology 10:161-174.
Rao VK, Ow JR, Shankar S, Bharathy N, Manikadan J and Taneja R. (2016) G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation. Nucleic Acids Research 44: 8129-8143.
Bharathy N, Suriyamurthy S, Rao VK, Lim HJ, Chakraborty P, Vasudevan M, Dhamne A, Chang K, Lee V, Kundu T, Taneja R. (2016) P/CAF mediates Pax3-Foxo1 dependent oncogenesis in alveolar rhabdomyosarcoma. J Pathology 240: 269-281.
Acharjee S, Chung T-K, Gopinadhan S, Shankar SR, Wang Y, Li L, Vercherat C, Gulbagci NT, Rossner MJ, Taneja R. (2014). Sharp-1 regulates TGF-signaling and skeletal muscle regeneration. J Cell Science 127:599-608.
Shankar SR, Bahirvani AG, Rao VK, Bharathy N, Ow JR and Taneja R. (2013). G9a, a multipotent regulator of gene expression. Epigenetics 8:16-22.
Ling BMT, Bharathy N, Chung T-K, Kok WK, Li SD, Tan YH, Rao VK, Gopinadhan S, Sartorelli V, Walsh MJ, and Taneja R. (2012). Lysine methyltransferase G9a methylates the transcription factor Myod and regulates skeletal muscle differentiation. Proc. Natl. Acad. Sci. (USA) 109:841-846.
Vercherat C, Chung T-K, Yalcin S, Gulbagci N, Gopinadhan S, Ghaffari S and Taneja R. (2009). Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Human Molecular Genetics 18:4304-4316 (*featured on journal cover).
Gulbagci N, Li L, Ling B, Gopinadhan S, Walsh, M, Rossner M, Nave KA and Taneja R (2009). Sharp-1 inhibits adipogenic differentiation by regulating C/EBP activity. EMBO Reports 10:79-86.
Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, Chung T-K, Thin T, and Taneja R. (2007). Stra13 regulates satellite cell activation by antagonizing Notch signaling. Journal of Cell Biology 177:647-57.
Thin T, Li L, Chung T-K, Sun H, and Taneja R (2007). Stra13 is induced by genotoxic stress and is required for ionizing radiation induced apoptosis. EMBO Reports 8:401-407.
Sun H, Lu B, Li R-Q, Flavell RA and Taneja R. (2001). Defective T-cell activation and autoimmune disorder in Stra13-deficient mice. Nature Immunology 2: 1040-1047.
Dhar M and Taneja, R. (2001). Cross regulatory interaction between Stra13 and USF results in functional antagonism. Oncogene 20: 4750-4756.
Sun, H and Taneja, R. (2000). Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC) dependent and HDAC independent mechanisms. Proc. Natl. Acad. Sci (USA) 97: 4058-4063.