Lab Interests Voltage-gated Calcium (CaV) Channels Voltage-gated Ca2+ channels play an important and essential role in numerous physiological processes and they open in response to membrane depolarization to allow rapid entry of Ca2+ ions to initiate many physiological effects like muscle contraction, neurotransmitter release, gene expression or hormone secretion.Alternative splicing of CaV channels has been shown to be dynamically regulated in development, physiology and pathophysiology. The exquisite fine-tuning of channel structure through post-transcriptional mechanisms, such as alternative splicing or RNA editing, diversifies protein functions to customize for specific requirements of cellular, physiological or pathological conditions. Our laboratory’s research interests include: |
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