Autophagy and Cancer Cell Biology Lab

SHEN Han-Ming

Shen Han Ming

Educational Background: MD, MPH, PhD

Position: Associate Professor

Contact number/s: 65-6516 4998 (office)

Contact number/s: 65-6516 6406 (lab)

Fax number:65-6778-8161

Location of Office:
Department of Physiology, Yong Loo Lin School of Medicine, NUS
MD9 2 Medical Drive #04-13 Singapore 117597

Location of Laboratory: MD9 #03-01

Name of Laboratory: Autophagy and Cancer Cell Biology Lab

Autophagy: Regulatory Mechanisms and Biological Functions in Cancer
Involvement of ROS and Oxidative Stress in Cell Death (Apoptotic and Non Apoptotic Cell Death)
Antioxidants and Natural Products as Anti-Cancer Agents

Tan SH, Shui GH, Zhou J, Wenk MR, Shen HM*. Induction of autophagy by free fatty acids via a PKC-mediated signalling pathway independent of mTOR. J Biol Chem.2012 Mar 9. [Epub ahead of print]
Zhou J, Hu SE, Tan SH, Cao R, Chen Y, Xia DJ, Zhu XQ, Yang XF, Ong CN, Shen HM*. Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy 8: 338-349, 2012
Wu YT, Tan HL, Huang Q, Ong CN, Shen HM*. TNFα Autocrine Is Required for Programmed Necrosis in L929 Cells Induced by Caspase Inhibitors. Cell Death and Differentiation 18:26-37, 2011.
Ng SK, Chen B, Wu YT, Zhou J, Shen HM*. Constitutive mTOR activation suppresses autophagy and sensitizes TSC2-null cells to cell death. Autophagy 7: 1173-1186. 2011.
Wu YT, Tan HL, Shi GH, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM*. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III PI3K. J Biol Chem 285:10850-10861, 2010 (this article was featured in Faulty of 1000 Biology (http://f1000biology.com/article/id/3091959/evaluation)