In Indian Ayurvedic medicine, black cardamom has been used in formulations to treat cancer and lung conditions. A team of researchers from the NUS Faculty of Science, NUS Yong Loo Lin School of Medicine, and NUS College of Design and Engineering studied the scientific basis behind this traditional medicinal practice and provided evidence of the cytotoxic effect of black cardamom on lung cancer cells. The research highlighted the spice as a source of potent bioactives, such as cardamonin and alpinetin, which could be used in the treatment or prevention of lung cancer. The study is the first to report the association of black cardamom extract with oxidative stress induction in lung cancer cells, and compare the spice’s effects on lung, breast and liver cancer cells.
“With black cardamom being commonly used as an important spice in cooking, further in-depth investigation about its impact on lung cancer progression in the pre-clinical models can provide strong evidence in support of the “food as medicine” philosophy of Hippocrates that has been neglected to great extent in the present day,” said Associate Professor Gautam Sethi from the Department of Pharmacology at the NUS Yong Loo Lin School of Medicine, who was a collaborator for the research.