A team lead by Research Assistant Professor Koh Cho Yeow from the Cardiovascular Diseases Translational Research Programme at Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) and Cardiovascular Research Institute, Associate Professor Mark Chan, from the Department of Medicine, NUS Medicine, who is also the Deputy Director (Clinical Research Matters) from the Cardiovascular Research Institute and National University Heart Centre, as well as, Professor R. Manjunatha Kini from the Department of Biological Sciences and Department of Pharmacology at NUS, developed a series of thrombin inhibitors to be powerful anticoagulants, commonly known as blood thinners or anticlotting medications.