Aaron FOO Song Chuan
Assistant Professor
 |
A/Prof. Gavin Stewart DAWE |
1
Dr Peiyan, WONG
Asst/P
2
Dr Yun-An, Andrea LIM
SRF
3
Dr Vanja CNOPS
RF
4
Nageiswari PARATHY
RA
5
Rajagopal Iyer VINAYA
LE
8
Win Lee, Edwin WONG
PG
 |
Prof. Edmund LEE Jon Deoon |
Nguyen TT, Chua JK, Seah KS, Koo SH, Yee JY, Yang EG, Lim KK, Pang SY, Yuen A, Zhang L, Ang WH, Dymock B, Lee EJ, Chen ES. Predicting chemotherapeutic drug combinations through gene network profiling. Sci Rep. 2016 Jan 21;6:18658.
Koo SH, Lo YL, Yee JY, Lee EJ. Genetic and/or non-genetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicity. Expert Opin Drug Metab Toxicol. 2015 Dec;11(12):1821-37.
Tay Z, Koo SH, Nguyen TT, Tan TS, Chen ML, Chin CF, Lim KK, Ang WH, Bay BH, Lee EJ, Chen ES. P-glycoprotein and vacuolar ATPase synergistically confer anthracycline resistance to fission yeast and human cells. Curr Med Chem. 2014;21(2):251-60
Brunham LR, Chan SL, Li R, Aminkeng F, Liu X, Saw WY, Ong RT, Pillai EN, Carleton BC, Toh D, Tan SH, Koo SH, Lee EJ, Chia KS, Ross CJ, Hayden MR, Sung C, Teo YY. Pharmacogenomic diversity in Singaporean populations and Europeans. Pharmacogenomics J. 2014 May 14(6):555-63
Pillai NE, Okada Y, Saw WY, Ong RT, Wang X, Tantoso E, Xu W, Peterson TA, Bielawny T, Ali M, Tay KY, Poh WT, Tan LW, Koo SH, Lim WY, Soong R, Wenk M, Raychaudhuri S, Little P, Plummer FA, Lee EJ, Chia KS, Luo M, De Bakker PI, Teo YY. Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Hum Mol Genet. 2014 23(16):4443-51
Yee JY, Limenta LM, Rogers K, Rogers SM, Tay VS, Lee EJ. Ensuring good quality RNA for quantitative real-time pcr isolated from renal proximal tubular cells using laser capture microdissection. BMC Res Notes. 2014 Jan 27;7:62..
Toh DS, Tan LL, Aw DC, Pang SM, Lim SH, Thirumoorthy T, Lee HY, Tay YK, Tan SK, Vasudevan A, Lateef A, Chong YY, Chan YC, Loke C, Chan CL, Koay ES, Ren EC, Lee EJ, Sung C. Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study. Pharmacogenomics J. 2014 14(4):316-21
Chew SC, Lim J, Singh O, Chen X, Tan EH, Lee EJ, Chowbay B. Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients. Eur J Clin Pharmacol. 2014;70(2):155-66.
Toh DS, Limenta LM, Yee JY, Wang LZ, Goh BC, Murray M, Lee EJ. Effect of Mushroom Diet on Pharmacokinetics of Gabapentin in Healthy Chinese Subjects. Br J Clin Pharmacol. 2013 78(1):129-3
Tay Z, Koo SH, Nguyen TT, Tan TS, Chen ML, Chin CF, Lim KK, Ang WH, Bay BH, Lee EJ, Chen ES. P-glycoprotein and vacuolar ATPase synergistically confer anthracycline resistance to fission yeast and human cells. Curr Med Chem. 2014;21(2):251-60.
 |
Christopher CHEN Li-Hsian |
SJ van Veluw, S Hilal, HJ Kuiff, MK Ikram, X Xin, BY Tan, N Venketasubramanian, GJ Biessels, C Chen. Cortical Microinfarcts on 3T MRI : Clinical Correlates in Memory Clinic Patients. Alzheimer’s & Dementia 11 (2015) 1500-9 IF=17.472
X Xu, S Hilal, SL Collinson, EJY Chong, MK Ikram, N Venketasubramanian, CLH Chen The Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition Stroke 46 (2015) 2808-14 IF=6.018
S Hilal, YL Chai, MK Ikram, S Elangovan, BY Tan, X Xin, JY Chong, N Venketasubramanian, AM Richards, JPC Chong, MKP Lai, C Chen. Markers of Cardiac Dysfunction in Cognitive Impairment and Dementia. Medicine 94 (2015) e297 IF=4.867
N Venketasubramanian, SHY Young, SS Tay, T Umapathi, AY Lao, HH Gan, AC Baroque II, , JC Navarro, HM Chang, JM Advincula, S Muengtaweepongsa, BPL Chan, CL Chua, N Wijekoon, HA de Silva, JHB Hiyadan, NC Suwanwela, KSL Wong, N Poungvarin, GB Eow, CF Lee, CLH Chen. CHInese Medicine NeuroAiD Efficacy on Stroke recovery – Extension Study (CHIMES-E : A multicenter study of long-term efficacy Cerebrovascular Diseases 39 (2015) 309-18 IF=3.698
ENOS Trial Investigators, Bath PMW, Woodhouse L, Scutt P, Krishnan K, Wardlaw JM, Bereczki D, Sprigg N, Berge E, Beridze M, Caso V, Chen C, Christensen H, Collins R, El Etribi A, Laska AC, Lees KR, Ozturk S, Phillips S, Pocock S, de Silva HA, Szatmari S, Utton S. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet. 385 (2015) 617-28 IF=39.207
CY Cheung,,YT Ong, MK Ikram,, SY Ong, X Li, S Hilal, JA Catindig, N Venketasubramanian, P Yap,D Seow, CP Chen, TY Wong Microvascular network alterations in the retina of patients with Alzheimer’s Disease Alzheimer's and Dementia 10 (2014) 135-42 IF=17.472
CLH Chen, N Venketasubramanian, CF Lee, KSL Wong, MG Bousser for the CHIMES Investigators. Effects of MLC601 on Early Vascular Events in Post-stroke Patients – The CHIMES Study Stroke 44 (2013) 3580-3583 IF=6.018
CLH Chen, SHY Young, HH Gan, R Singh, AY Lao, AC Baroque II, HM Chang, JHB Hiyadan, CL Chua, JM Advincula, S Muengtaweepongsa, BPL Chan, HA de Silva, S Towanabut, NC Suwanwela, N Poungvarin, S Chankrachang, KSL Wong, GB Eow, JC Navarro, N Venketasubramanian, CF Lee, M-G Bousser, for the CHIMES Study Investigators Chinese Medicine Neuroaid Efficacy on Stroke Recovery A Double-Blind, Placebo-Controlled, Randomized Study Stroke 44 (2013) 2093-2100 IF=6.01
JM Wardlaw,EE Smith, GJ Biessels, C Cordonnier, F Fazekas, R Frayne, RI Lindley, JT O’Brien, F Barkhof, OR Benavente, S Black, C Brayne, M Breteler, H Chabriat, C deCarli, FE de Leeuw, F Douba, M Duering, M Fox, S Greenberg, V Hachinski, I Kilimann, V Mok, R van Oosterbrugge, Pantoni, O Speck, BCM Stephan, S Teipel, A Viswanathan, D Werring, C Chen, C Smith, M van Buchem, B Norrving, PB Gorelick, M Dichgans. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration: A united approach STandards for ReportIng Vascular Changes on NEuroimaging (STRIVE) v1 Lancet Neurology 12 (2013) 822-38 IF=21.823
S Hilal, MK Ikram, M Saini, JA Catindig, CS Tan, YH Dong, L Lim, A Qui, TY Wong, C Chen, N Venketasubramanian Prevalence of and risk factors for cognitive impairment and dementia in Chinese: The Epidemiology of Dementia in Singapore (EDIS) Study J Neurology Neurosurgery & Psychiatry 84 (2013) 686-92 IF=5.58
1
Dr Francis SARIDIN
Research Fellow
2
Ms Joyce Chong
Research Assistant
3
Ms Cheuk Ni KAN
Research Assistant
4
Hao Ping Nathan LIANG
Research Assistant
5
Zi Xuen WONG
Research Assistant
6
Soon Yee, Samuel CHIA
Research Assistant
 |
Prof. Fred WONG Wai Shiu |
The long-term goals of his research program is to investigate mechanism-based pharmacological agents for the treatment of airway inflammation, oxidative damage, DNA damage and airway remodeling in asthma, COPD, idiopathic pulmonary fibrosis, viral/bacterial exacerbation conditions and steroid resistance, using small molecule drugs like natural/nutritional product bioactive molecules, target-specific blockers, antisense oligonucleotides/siRNA, pharmacoproteomics and pharmacometabolomics. The Respiratory Pharmacology Laboratory has been continuously supported by extramural grants over the past 27 years.
 |
 |
1
Wupeng, Winston LIAO
Senior Research Fellow
2
Caroline SEVOZ-COUCHE
Senior Researcher in INSERM (Paris, France)
3
Thi Ngoc Quy TRAN
Research Fellow
4
Jong Huat TEE
Research Fellow
5
Chew Kiat, Matthew HENG
PhD Student
6
Phyllis Xiu Li GAN
PhD Student
7
Christabel Clare Mei Yun CHAN
Research Assistant (DDOP)
 |
A/P KWON Seok (Soga) Associate Professor Regulatory Toxicology, Risk Assessment |
Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM, Husøy T, Svendsen C, Tsaioun K, Ashikaga T, Bloch D, Cavoski A, Chiu WA, Davies HG, Giusti A, Hartung T, Hirabayashi Y, Hogberg HT, Joglekar R, Kojima H, Krishnan K, Kwon S, Osborne OJ, Roggen E, Rooney AA, Rousselle C, Sass JB, Sepai O, Simanainen U, Thayer KA, Tong W, Wikoff D, Wright F, Whaley P (2024). Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Arch Toxicol. doi: 10.1007/s00204-024-03802-6.
Lee BM, Bearth A, Tighe RM, Kim M, Tan S, Kwon S (2023). Biocidal Products: Opportunities in Risk Assessment, Management and Communication. Risk Analysis, 1–15.
 |
A/P LOW Chian Ming Neuropharmacology, NMDA Receptors, Neuroinflammation, Pain, Personalized Medicine/ Channelopathies, Chemical Biology |
1
Cheong Yoke Ping
Lab Manager (Pharmacology)
2
Dr. Wu Zhi Yuan
Snr. Res. Fellow (Anaesthesia)
 |
A/P Gautam SETHI |
A/P Gautam SETHI is the editorial board member of 11 different international journals:
1
Ms. Fan Lu
LO
 |
A/P Judy SNG Chia Ghee Lab Website: |
Juanita S. M. Kong, Teo Boon See, Lee Yueh Jia, Pabba Anubharath, Edmund J.D. Lee and Judy C.G Sng. Virtual Integrated Patient: An AI supplementary tool for second year medical students (in print, TAPs).
Maniclang, M.A.F., Hong R.Y.H., Marzin, M., Amellal, K., Rajendran K, Lee E.J.D., & Sng J.C.G. (2018). Evaluating the effectiveness of enhancing webcasts with digital tagging. Asian Journal of the Scholarship of Teaching and Learning, 8(1), 5-24
Maniclang, M. A. F., Ang, Z. L. T., Hong, R. Y. H., Lee, E. J. D., & Sng, J. C. G. (2018). Students’ perceptions of webcast lectures and online video materials: Results of a survey at a higher education institution in Singapore. Asian Journal of the Scholarship of Teaching and Learning, 8(2). 150-180.
Puang, S.J., Elanggovan, B., Ching, T. & Sng J.C.G. (2020). MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment. Neuronal Signal, 4 (3): NS20190147.
Ho, N. F., Tng, J., Wang, M., Chen, G., Subbaraju, V., Shukor, S., Ng, D., Tan, B. L., Puang, S. J., Kho, S. H., Siew, R., Sin, G. L., Eu, P. W., Zhou, J., Sng, J., Sim, K., & Medalia, A. (2020). Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia. Journal of psychiatric research, S0022-3956(19)31081-7.
Shun Qiang Lo, Judy C. G. Sng & George J. Augustine (2017) Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports 7, Article number: 7271.
Lee PK, Goh WW and Judy Sng (2017) Network-based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation. J Neurochem, 140(4):613-628.
1
Anubharath PABBA
RA
2
Yueh Jia LEE
RA
3
Juanita KONG
RA
4
Stephanie CLAUDINE
RA
5
Sonja KOROMPIS
RF
6
Boon See TEO
Adjunct Asst/P
 |
A/P Chay Hoon TAN |
The Case for Stage Specific Frailty Interventions Spanning Community Aging to Cognitive Impairment J Am Med Dir Assoc 2015 Nov;16(11):1003.e13-9
Sex specific difference in the risk factors for sarcopenia amongst community-dwelling older adults AGE 2015, 37:121
International-study-on-antidepressant-prescription-pattern-at-40-major-psychiatric-institutions-and- Asia Pac Psychiatry 2015 Dec 23;7(4):366-74. Epub 2015 Feb 23.
Use of clozapine in older schizophrenia patients in East Asia between 2001 and 2009. PLoS ONE, 2013 Jun 10;8(6):e66154
TOMM40 Alterations in Alzheimer's Disease Over a 2-Year Follow-Up Period. Journal of Alzheimer's Disease, 44(1) : 57-61(2015)
Bousman CA, Sarris J, Won ES, Chang HS, Singh A, Lee HY, Ham BJ, Tan CH, Lee MS, Ng C. Escitalopram efficacy in depression: a cross ethicity examination of the serotonin transporter promoter polymorphism J Clin Psychopharmacol. 2014 Oct;34(5):645-8.
QTc prolongation in schizophrenia patients in Asia clinical correlates and trends between 2004 and 2009 http://www.pubfacts.com/detail/25611192/
Are medical students views of an ideal physician eroding-A study on perceived qualities of a role model Ann Acad Med Singapore 2015 Mar;44(3):79-84
Underdiagnosis of delirium on admission and prediction of patients who will develop delirium during their inpatient stay: a pilot study Singapore Med J 2016; 57(1): 1-4
Globalization-economics-and-professionalism Med Teach 2015 Sep 15;37(9):850-5. Epub 2015 Jun 15.
 |
Dr Alan Prem KUMAR Office: Lab Location: MD3, 16 Medical Drive, Level 6, Bench 5 & 11, Singapore 117600. |
For years, scientists have been toiling to understand metastasis, the process that allows cancer cells to break off from their tumor of origin and take root in a different tissue. Today, the problem is as urgent as ever. Metastasis causes nine out of ten deaths from cancer. Our group is focused on uncovering new cues that drive the spread of cancer and develop target-based precision therapies to prevent metastasis in several types of female reproductive cancers. In addition, tumors can highjack certain pathways to subvert immune surveillance, blocking entry of immune cells, promote metastasis and protect tumors from immune and therapeutic destruction. Hence, our group is also focused on developing new strategies to overcome immune evasive mechanisms of cancer cells and sensitize them to immunotherapy.
1 of 3 recipients of 2017 & 2021 Graduate Mentor of the Year (GRAMAY) Award – honouring faculty staff in recognition of excellence in mentorship and professional development of undergraduate and postgraduate students; supervised 66 students over 12 years who have won total of 26 outstanding contribution awards.
Set-up joint “NUSMed B2B Collaboration Grant” between NUS Medicine postdocs and clinicians from CSDU starting 2021 – 3 awards of USD60K each per year provided jointly by CSDU and NUHS RO.
Recipient of Highly Cited Researchers 2020 by Clarivate - 1 of 3 researchers from NUS Medicine with names drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science citation index.
Developed cross-collaboration with multiple stakeholders both within NUS faculties and externally with local and international corporations, industry bodies, biotech firms and institutions.
Built NUS Medicine Office of Postdoctoral Affairs from scratch to guide postdoc students on diverse career and personal development opportunities, facilitating open dialogue to be future ready and forum to connect potential employers with postdoc candidates via database and networking between NUS Medicine Alumni.
Active Member - European Association for Cancer Research, Nottingham, UK, 2018 - Present
Member - Singapore Pharmacological Society, Singapore, 2018 - Present
Member - AUM Biosciences, Singapore, 2018 - Present
Member - SMS Seva Healthcare, Government of India, India, 2018 - Present
Member - The Sparks Foundation, Singapore, 2018 - Present
Active Member - American Association for Cancer Research, Philadelphia, PA, USA, 2015 - Present
1
Dr. Hui Yan, Maggie LAM
Research Fellow
2
E Hui, Clarissa LEE
Postgraduate student
3
Huiling YAP
Laboratory Technologist
4
Kay Min, Jocelyn TEO
Research Assistant
 |
Dr Thi Nguyet Minh LE Lab Web Page: |
Extracellular vesicles (EVs) are natural carriers of bioactive molecules in intercellular communication hence, they are also ideal vehicles for therapeutic molecules. Recently, we have developed a strategy to harness EVs from red blood cells (RBCs) for the delivery of drugs to cancer cells. RBCs are readily available from blood banks and they release a large amount of EVs hence, it is easy to purify RBCEVs in large quantities without any expensive and labor-intensive cell culture. RBCEVs mediate robust delivery of therapeutic nucleic acids and proteins to both leukemia cells and solid cancer cells for efficient oncogene inhibition. Moreover, this delivery platform is safe as RBCEVs are devoid of DNA, growth factors, and toxic substances. We have also engineered RBCEVs with peptide and antibody conjugation for targeted delivery. Our study was published in more than 20 papers. The RBCEV technology has been licensed to Carmine Therapeutics. We are currently developing multiple applications of RBCEV-mediated gene therapy for cancer, COVID-19, and other diseases. We are also investigating the mechanisms that mediate the uptake and intracellular trafficking of RBCEVs. This study will help us to develop RBCEVs into a versatile drug delivery platform with high efficiency, low toxicity, and high specificity.
 |
Dr Hong Yong PEH Research Assistant Professor and Principal Investigator BSc (Hons), PhD Office: CeLS, Level 3, #03-06-K Research Area Keywords: Pro-resolving lipid mediators; resolution of inflammation; innate immunity; efferocytosis; granulocyte trafficking; respiratory diseases; maternal/offspring; targeted lipidomics; immunopharmacology |
* co-first author; # corresponding author
 |
Dr Inthrani RAJA INDRAN |
 |
Dr Kim Peng, Mitchell LAI |
Yang Y, Torta F, Wenk M, Arai K, Herr DR, Wong PT, Lai MK (2016) Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. Neurochemistry International In Press.
Wong SY, Tan MG, Banks WA, Wong WS, Wong PT, Lai MK (2016) Andrographolide attenuates LPS-stimulated upregulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes. Journal of Neuroinflammation 13:34.
Lee C, Low CY, Francis PT, Attems J, Wong PT, Lai MK, Tan MG (2016) An isoform specific role of FynT tyrosine kinase in Alzheimer’s disease. Journal of Neurochemistry 136:637-650.
Lee JH, Koh SQ, Guadagna S, Francis PT, Esiri MM, Chen CP, Wong PT, Dawe GS, Lai MK (2016) Altered relaxin family receptors-RXFP1 and RXFP3 in the neocortex of depressed Alzheimer’s disease patients. Psychopharmacology 233:591-598.
Chan SJ, Lim TW, Chai C, Yamamoto M, Lo EH, Lai MK, Wong PT (2015) Cystathionine β-synthase inhibition is a potential therapeutic approach to treatment of ischemic injury. ASN Neuro 7(2) pii: 1759091415578711.
Mohamed NE, Lee JH, Francis PT, Esiri MM, Chen CP, Lai MK (2015) Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer’s disease. Journal of Alzheimers Disease 44:431-437.
Hilal S, Chai YL, Ikram MK, Elangovan S, Tan BY, Xu X, Chong JY, Venketasubramanian N, Richards AM, Chong JP, Lai MK, Chen C (2015) Markers of cardiac dysfunction in cognitive impairment and dementia. Medicine (Baltimore) 94:e297.
Lai MK, Esiri MM, Tan MG. Genome-wide profiling of alternative splicing in Alzheimer’s disease. Genomics Data (2014) 2:290-292.
Lam SM, Wang Y, Duan X, Wenk MR, Kalaria RN, Chen CP, Lai MK, Shui GH (2014) The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiology of Aging 35:2369-2381.
Ramírez MJ, Lai MK, Tordera RM, Francis PT (2014) Serotonergic therapies for cognitive symptoms in Alzheimer’s disease: Rationale and current status. Drugs 74:729-736.
1
Dr Jasinda Lee
Research Fellow
2
Dr Wei WANG
Research Fellow
3
Alcantara Leicester SHAWN
Lab Technologist
4
Yuek Ling CHAI
Postgraduate (main-supervisor)
5
Ruifen, Joyce CHONG
Postgraduate
6
Giselle Ava PANTALEON
Postgraduate
7
Ai Ling CHEN
Postgraduate
8
Xin Ying CHUA
Postgraduate(co-supervisor)
9
SALAI Kaung Htet Tun
Postgraduate(co-supervisor)
 |
Dr Rajkumar RAMAMOORTHY |
Cheng MY, Damalerio RB, Chen W, Rajkumar R, Dawe GS (2019). Ultracompact Multielectrode Array for Neurological Monitoring. Sensors 19: 2286. IF: 2.48
Rajkumar R, Dawe GS (2018). OBscure but not OBsolete: Perturbations of the frontal cortex in common between rodent olfactory bulbectomy model and major depression. Journal of Chemical Neuroanatomy 91: 63-100. IF: 2.16
Rajkumar R, Kumar JR, Dawe GS (2017). Priming locus coeruleus noradrenergic modulation of medial perforant path-dentate gyrus synaptic plasticity. Neurobiology of Learning and Memory 138: 215-225. IF: 3.54
Kumar JR, Rajkumar R, Jayakody T, Marwari S, Hong JM, Ma S, GundlachAL, Lai MKP, Dawe GS (2017). Relaxin’ the brain: A case for targeting the nucleus incertus network and relaxin-3/RXFP3 neuropeptide/receptor systems in neuropsychiatric disorders. British Journal of Pharmacology 174: 1061-1076. IF: 5.49 [Appeared in Wiley press release 06 September 2016.]
 |
Dr Yang-Wei, David FANN |
 |
Dr Nurulhuda MUSTAFA |
 |
Dr Neelima GUPTA |
 |
Dr Priya PARANTHAMAN |
 |
Dr WANG Ziteng |
 |
Dr Li Ren KONG |
 |
Prof. GOH Boon Cher |
 |
Prof. Dean HO |
Prof. Dean Ho’s research interests include the application of Augmented Artificial Intelligence (AI) to individualize and optimize combination therapy for a broad range of indications ranging from oncology to infectious diseases. In addition, he has developed novel nanocarbon-based drug delivery and imaging agents. He has led multiple clinical studies for both the Augmented AI and nanocarbon platforms.
D.K. Lee, T. Kee, Z. Liang, D. Hsiou, D. Miya, B. Wu, E. Osawa, E.K. Chow, E. Sung, M. Kang, and D. Ho, Clinical Validation of a Nanodiamond-Embedded Thermoplastic Biomaterial, Proceedings of the National Academy of Sciences of the United States of America, 114 (45), E9445-E9454, 2017.
C. Hong, D. Song, D.K. Lee, L. Lin, H.C. Pan, D. Lee, P. Deng, Z. Liu, D. Hadaya, A. Mohammad, X. Zhang, M. Lee, C.Y. Wang, and D. Ho, Reducing Post-Treatment Relapse in Cleft Lip Palatal Expansion Using an Injectable Estrogen-Nanodiamond Hydrogel, Proceedings of the National Academy of Sciences of the United States of America, 114(35), E7218-E7225, 2017.
A. Zarrinpar, D.-K. Lee, A. Silva, N. Datta, T. Kee, C. Eriksen, K. Weigle, V. Agopian, F. Kaldas,D. Farmer, S.E. Wang, R. Busuttil, C.-M. Ho, and D. Ho, Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform. Science Translational Medicine 2016, 8 (333), 333ra49-333ra49. Cover Article.
Dean Ho, Katherine Chung-Huei Wang, and Edward Chow, Nanodiamonds: The Intersection of Nanotechnology, Drug Development, and Personalized Medicine, Science Advances, e1500439, 2015.
Hann Wang, Dong-Keun Lee, Kai-Yu Chen, Jing-Yao Chen, Kangyi Zhang, Aleidy Silva, Chih-Ming Ho, and Dean Ho, Mechanism-Independent Optimization of Combinatorial Nanodiamond and Unmodified Drug Delivery Using a Phenotypically Driven Platform Technology, ACS Nano, 9 (3), 3332-3344, 2015.
E.K. Chow and D. Ho “Cancer Nanomedicine: From Drug Delivery to Imaging,” Science Translational Medicine, 2013, 5, 216rv4. Cover Article
L. Moore, E.K.-H.Chow, E. Osawa, J.M. Bishop, and D. Ho, Diamond-Lipid Hybrids Enhance Chemotherapeutic Tolerance and Mediate Tumor Regression. Advanced Materials, 25(26), 3532-3541, 2013. Cover Article
E. K. Chow, X.-Q. Zhang, M. Chen, R. Lam, E. Robinson, H. Huang, D. Schaffer, E. Osawa, A. Goga, and D. Ho, Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Science Translational Medicine 3, 73ra21, 2011. Cover Article
V. Mochalin, O. Shenderova, D. Ho, Y. Gogotsi, “The Properties and Applications of Nanodiamonds,” Nature Nanotechnology, 7, 11-23, 2011.
H. Huang, E. Pierstorff, E. Osawa, and D. Ho “Active Nanodiamond Hydrogels for Chemotherapeutic Delivery”, Nano Letters, 7, 3305-3314, 2007.
 |
Prof. Philip Keith MOORE |
We have previously reported that H2S exhibits potent vasodilator and anti-inflammatory activity suggesting that this novel gas may play a part in cardiovascular physiology and pathophysiology. This project seeks to determine whether a deficiency of vasculoprotective H2S may precipitate atherosclerotic disease. Experiments will be carried out in ApoE-/- atherosclerotic mice and combined with investigation of blood vessels obtained from human volunteers collected, after informed consent, during coronary artery surgery. The project centres upon an integrative approach involving studies both in animals and in cell culture.
A number of projects are currently under way to determine the biological effects of a range of novel H2S donor agents in inflammation and cardiovascular disease. Possible target for these drugs which are currently being studied include lipopolysaccharide-evoked septic shock and adjuvant-induced knee joint arthritis. A range of techniques including cell culture and associated biochemical and molecular biological characterisation as well as studies in intact animals are ongoing.
Li, L., Bhatia, M. Zhu, Y.Z., Zhu, Y.C., Ramnath, R.D., Wang, Z.J., Anaur, F., Whiteman, M., Salto-Tellez, M. & Moore, P.K. (2005). Hydrogen sulfide is a novel mediator of endotoxic shock. FASEB J., 19, 1196-1198.
Bhatia, M., Sidhapuriwala, J., Moochhala, S.M. & Moore, P.K. (2005).Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. Br. J. Pharmacol., 145, 141-144.
Rose, P., Moore, P.K., Shen, H.M., Ong, C.N. & Whiteman, M. (2005). Hydrogen sulfide protects colon cancer cells from chemopreventative agent b-phenylethyl isothiocyanate-induced apoptosis. World Journal of Gastroenterology, 11, 3990-3997.
Rose, P., Whiteman, M., Armstrong, J.S., Moore, P.K. & Zhu, Y.Z. (2005). Bioactive S-alk(en)yl cysteine sulfoxides metabolites in the genus Allium: The Chemistry of potential therapeutic agents. Natural Products Report, 22, 351-368.
Lee, S.W., Hu, Y.S., Lu,Q., Moore, P.K., Wong, P.T. & Bian, J.S. (2005). Hydrogen sulphide regulates calcium homeostasis in BV-2 microglial cells. Glia, 54, 116-124.
Cao, Y., Adhikari, S., Moore, P.K. & Bhatia M. (2005). Mechanism of Induction of Pancreatic Acinar Cell Apoptosis by Hydrogen Sulfide. Am. J. Physiol., 291, 503-510.
Huang, J., Moochhala, S.M., Moore, P.K. & Bhatia, M. (2005). Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury. Shock, 24, 182-187.
Yusuf, M., Tan, B.T.H., Hsu, A., Bhatia, M. & Moore, P.K. (2005). Experimentally induced type 1 diabetes is associated with impaired hydrogen sulfide biosynthesis. Biochem. Biophys. Res. Comm., 333, 1146-1152.
Collin, M., Anuar, F., Murch, O., Bhatia, M. & Moore, P.K. (2005). Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br. J. Pharmacol., 146, 498-505.
Chua, Y.L., Zhang, D., Boelsterli, U., Moore, P.K., Whiteman, M. & Armstrong, J.S. (2005). Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA. Biochem. Biophys. Res. Commun., 337, 375-81.
 |
Dr Saima HILAL |
-
 |
Dr Peiyan WONG |
-
 |
Dr KOH Cho Yeow Lecturer PhD Office: - Research Area Keywords: |
1. -
2. -
 |
Dr Lingzhi WANG |
Cancer is a major burden of disease worldwide. Cancer is usually asymptomatic early in its disease course and the majority of patients present with advanced stage disease at the time of initial diagnosis. Thus, early diagnosis of cancerous diseases is an unmet clinical need. My research interests can be summarized as follows.
 |
Dr Lucas LIM Jun Hao Office: |
 |
Dr John MOK Office: |
 |
Dr Bee Kee, Serena SEAH |
 |
Prof. Jerold CHUN Office: |
Understanding how the brain works and creating meaningful therapies to treat brain diseases is the goal of my research. Many lessons can be gained from an understanding of how the brain is impacted by the immune system and inflammation, an approach that we have been pursuing for over 25 years and has led to new insights that include components of V(D)J recombination genes in the brain, analogous DNA fragmentation and cell death, and identification of key lysophospholipid receptors shown to be involved in lymphocyte trafficking. This basic research has contributed to the development of genuine therapeutics for the inflammatory neuroimmune disease, multiple sclerosis, and involves direct CNS effects, as well as immunological effects, in multiple sclerosis models
Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, Chun J. LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction. Sci Adv. 2019 Oct 9;5(10):eaax2011.
Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J. Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature. 2018 Nov;563(7733):639-645.
Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung H-L, Chen S, Vijayaraghavan R, Wong J, Chen C, Sheng X, Kaper F, Shen R, Ronaghi M, Fan J-B, *Wang W, *Chun J, *Zhang K. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science 2016;352(6293):1586-1590. *Co-senior authors.
Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J. Genomic mosaicism with increased amyloid precursor protein (APP) copy number in single neurons from sporadic Alzheimer’s disease brains. eLife 2015;4:e05116.
Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J. Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development. J Neurosci 2012;32(46):16213-16222.
Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor (S1P1) modulation. Proc Natl Acad Sci USA 2011;108(2):751-756.
Herr KJ, Herr DR, Lee CW, Noguchi K, Chun J. Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling. Proc Natl Acad Sci USA 2011;108(37):15444-15449.
Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Arai H, Aoki J, Chun J. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature 2005;435:104-108.
Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 1996;135:1071-1083.
Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. The recombination activating gene- 1 (RAG-1) transcript is present in the murine central nervous system. Cell 1991;64:189-200.
