Faculty

Dr Jaishree Tripathi

Dr. Jaishree Tripathi joined the Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, NUS, in 2022 as a Lecturer and has over 13 years of research experience investigating various aspects of malaria parasite biology and host-parasite interactions. Dr. Tripathi graduated from the University of Cambridge in 2015, where she developed stem-cell based models to study host-parasite interactions during the liver stage infection of rodent malaria parasite Plasmodium berghei3. During her postdoctoral research, Dr. Tripathi applied single cell transcriptomics approaches to study stochastic gene expression in the human malaria parasites Plasmodium falciparum1. In addition to research, Dr. Tripathi is actively involved in teaching various life sciences undergraduate and graduate modules and leads the Infectious Diseases Management Track for the Masters in Applied Biomedicine programme offered by the Department of Microbiology and Immunology.

Publications:

  1. Tripathi J., Zhu L., Nayak S., Stoklasa M., Bozdech Z. (2022). Stochastic Expression of Invasion Genes in Plasmodium falciparum Nature Communications, 13(1):3004.
  2. Kucharski M.*, Tripathi J.*, Nayak S., Zhu L. Wirjanata G., van der Pluijm R. W., Dhorda M., Dondorp A. & Bozdech Z. (2020). A Comprehensive RNA Handling and Transcriptomics Guide for High-Throughput Processing of Plasmodium Blood-Stage Samples. Malaria Journal, 19, 363. (* equal contribution)
  3. Tripathi, J., Segeritz C. P., Griffiths G., Bushell W., Skarnes W. C., Vallier L., Mota M. M. & Billker O. (2020). A novel chemically differentiated mouse embryonic stem cell model to study liver stages of Plasmodium berghei. Stem Cell Reports, 14,1-12.
  4. Tripathi J.*, Stoklasa M.*, Nayak S., Low K.E., Lee E. Q. H., Renia L., Malleret B. and Bozdech Z. (2023). The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular senescence and drug resilience. bioRxiv: https://doi.org/10.1101/2023.01.29.526019 (* equal contribution)
  5. Zhu L., Tripathi J., Rocamora F. M., Miotto O., Pluijm R., Voss T. S., Mok S., Kwiatkowski D. P., Nosten F., Day N. P. J., White N. J., Dondorp A. M., Bozdech Z. & Tracking Resistance to Artemisinin Collaboration I. (2018). The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background. Nature Communications, 9:5158.
  6. Gupta, A.P., Lei Z., Tripathi J., Kucharski M., Patra A. & Bozdech Z. (2017). Histone 4 lysine 8 acetylation regulates proliferation and host-pathogen interaction in Plasmodium falciparum. Epigenetics & Chromatin, 10:40.
  7. Varunan, S.M., Tripathi, J., Bhattacharyya, S., Suhane, T. & Bhattacharyya, M.K. (2013). Plasmodium falciparum origin recognition complex subunit 1 (PfOrc1) functionally complements Δsir3 mutant of Saccharomyces cerevisiae. Molecular and Biochemical Parasitology, 191, 28–35
  8. Zhu L.*, van der Pluijm R. W.*, Kucharski M.*, Nayak S., Tripathi J., White N. J., Day N. P. J., Faiz A., Phyo A. P., Amaratunga C., Lek D., Ashley E.A., Nosten F., Smithuis F., Ginsburg H., Seidlein L., Lin K., Imwong M., Chotivanich K., Mayxay M., Dhorda M., Nguyen H. C., Nguyen T. N. T., Miotto O., Newton P. N., Jittamala P., Tripura R., Pukrittayakamee S., Peto T. J., , Hien T. T.,  Dondorp A. M. and Bozdech Z. (2022). Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response. Communications Biology, 5, 274.
  9. Mok S., Stokes B.H., Gnädig N. F., Ross L. S., Yeo T., Amaratunga C., Allman E., Solyakov L., Bottrill A. R., Tripathi J., Fairhurst R., Llinás M., Bozdech Z., Tobin A. B., Fidock D. A. (2021). Artemisinin-Resistant K13 Mutations Rewrite Plasmodium falciparum’s Intra-Erythrocytic Development and Alter Mitochondrial Physiology. Nature Communications, 12, 530.
  10. Naidu R., Chu T.T.T., Tripathi J. , Hu Y., Subramanian G., Tong J. X., Tripathi P., Fang K., Tan K. S. W., Lim C. T., Chan J. K. Y., Bozdech Z. and Chandramohanadas R. (2019). Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum. bioRxiv: https://doi.org/10.1101/862169