PHM5010 – Precision Biomarkers

Course Overview

Biomarkers, with potential to inform disease risk, state, treatment response and prognosis, are essential tools driving Precision Medicine to guide clinical decision making. This course aims to guide students through the entire journey from the biomarker discovery phase to the development phase of demonstrating analytical and clinical validity as well as clinical utility of biomarkers. This module will primarily focus on big-data omics-based approach to biomarker discovery. We will also discuss clinical applications of omics-based biomarkers as well as challenges in biomarker development.

Learning Outcomes

By the end of the course, the student will:

  • Know What are the characteristics of an ideal biomarker
  • Know What the various classifications of biomarkers
  • Understand the workflow from biomarker discovery to development
  • Discuss challenges in biomarker development
  • Discuss at least ONE clinical application of omics-based biomarkers including its advantages and limitations

Course Outline

  • Characteristics of an ideal clinical molecular biomarker
  • Classification of Biomarkers
  • Biomarker Discovery
  • Biomarker Development
  • Current state of OMICs-based biomarkers clinically
  • Challenges of biomarker development

Course Requirements

Student must have taken the core course Human Genomics in Precision Medicine or any similar modules.

Course Coordinators

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