Biomarkers, with potential to inform disease risk, state, treatment response and prognosis, are essential tools driving Precision Medicine to guide clinical decision making. This course aims to guide students through the entire journey from the biomarker discovery phase to the development phase of demonstrating analytical and clinical validity as well as clinical utility of biomarkers. This module will primarily focus on big-data omics-based approach to biomarker discovery. We will also discuss clinical applications of omics-based biomarkers as well as challenges in biomarker development.