NGUYEN lab

Publications

Selected research articles

  1. †,#Calame, D. G., †Wong, J. H., Panda, P., Nguyen, D. T., Leong, N. C. P., Sangermano, R., Patankar, S. G., Abdel-Hamid, M., AlAbdi, L., Safwat, S., Flannery, K. P., Dardas, Z., Fatih, J. M., Murali, C., Kannan, V., Lotze, T. E., Herman, I., Ammouri, F., Rezich, B., Efthymiou, S., Alavi, S., Murphy, D., Firoozfar, Z., Nasab, M. E., Bahreini, A., Ghasemi, M., Haridy, N. A., Goldouzi, H. R., Eghbal, F., Karimiani, E. G., Srinivasan, V. M., Gowda, V. K., Du, H., Jhangiani, S. N., Coban-Akdemir, Z., Marafi, D., Rodan, L., Isikay, S., Rosenfeld, J. A., Ramanathan, S., Staton, M., Oberg, K. C., Clark, R. D., Wenman, C., Loughlin, S., Saad, R., Ashraf, T., Male, A., Tadros, S., Boostani, R., Abdel-Salam, G. M. H., Zaki, M., Abdalla, E., Chiara Manzini, M., Pehlivan, D., Posey, J. E., Gibbs, R. A., Houlden, H., Alkuraya, F. S., Bujakowska, K., Maroofian, R., #Lupski, J. R. and #Long N. Nguyen. Biallelic variation in the choline and ethanolamine transporter FLVCR1 underlies a pleiotropic disease spectrum from adult neurodegeneration to severe developmental disorders. †co-first author; #co-corresponding author. (In bold: NUS researchers).                                                                                                                                                                                                                                                    
  2. Keiken Ri†, Tsai-Hsuan Weng†, Ainara Claveras Cabezudo†, Wiebke Jösting, Yu Zhang, Andre Bazzone, Nancy C.P. Leong, Sonja Welsch, Raymond T. Doty, Gonca Gursu, Tiffany Jia Ying Lim, Sarah Luise Schmidt, Janis L. Abkowitz, Gerhard Hummer#, Di Wu#, Long N Nguyen#, Schara Safarian#. Molecular mechanism of choline and ethanolamine transport in humans. Nature. May 2024. †co-first author; #co-corresponding author. (In bold: NUSresearchers)                                                                                                                                                                                                                                                    
  3. Hoa T.T. Ha, SiYi Liu, Xuan T.A. Nguyen, Linh K. Vo, Nancy C.P. Leong, Dat T. Nguyen, Shivaranjani Balamurugan, Pei Yen Lim, YaJun Wu, Eunju Seong, Toan Q. Nguyen, Jeongah Oh, Markus R. Wenk, Amaury Cazenave-Gassiot, Zuhal Yapici, Wei-Yi Ong, #Margit Burmeister, #Long N. Nguyen. Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models.  JCI insight. March 2024. In-Press. #co-orresponding author.                                                                                                                                                                                                                                                    
  4. *Xuan T.A. Nguyen, *Thanh Nha Uyen Le, Toan Q. Nguyen, Hoa Thi Thuy Ha, Anna Artati, Nancy C.P. Leong, Dat T. Nguyen, Pei Yen Lim, Adelia Vicanatalita Susanto, Huang Qianhui, Fam Ling, Leong Lo Ngah, Isabelle Bonne, Angela Lee, Jorge Granadillo, Catherine Gooch, Dejie Yu, Huang Hua, Tuck Wah Soong, Matthew Wook Chang, Markus R. Wenk, Jerzy Adamski, Amaury Cazenave-Gassiot, #Long N. Nguyen. MFSD7c functions as a transporter of choline at the blood-brain barrier. Cell Research. March 2024. IF= 44.1. #corresponding author. Link to the article: https://www.nature.com/articles/s41422-023-00923-y                                                                                                                                                                                                                                            
  5. *Yaning Duan, *Nancy C.P. Leong, *Jing Zhao, Yu Zhang, Dat T. Nguyen, Hoa T.T. Ha, Na Wang, Ruixue Xia, Zhenmei Xu, Zhengxiong Ma, Yu Qian, Han Yin, Xinyan Zhu, Yu Xia, #Long N. Nguyen, #Yuanzheng He. Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Research. Dec 2023. IF= 44.1. #co-corresponding author. Link to the article: https://www.nature.com/articles/s41422-023-00913-0. (In bold: NUS researchers)                                                                                                                                                                                                                                                    
  6. *Hoa Thi Thuy *Ha, Viresh Krishnan Sukumar, *Jonathan Wei Bao Chua, Dat T Nguyen, Toan Q Nguyen, Lina Hsiu Kim Lim, Amaury Cazenave-Gassiot, #Long N Nguyen. Mfsd7b facilitates choline transport and missense mutations affect choline transport function. Cellular and Molecular Life Sciences. Dec 2023. #Corresponding author.                                                                                                                                                                                                                                                    
  7. Zafrul Hasan, Toan Q. Nguyen, Brenda Wan Shing Lam, Jovi Hui Xin Wong, Caleb Cheng Yi Wong, Clarissa Kai Hui Tan, Jia Bo Yu, Chung Hwee Thiam, Yongliang Zhang, Veronique Angeli, #Long N. Nguyen. Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions. Cellular and Molecular Life Sciences. Nov 2022. #Corresponding author.                                                                                                                                                                                                                                                    
  8. *Uyen Thanh Nha Le, *Toan Q. Nguyen, Pazhanichamy Kalailingam, Yen Thi Kim Nguyen, Viresh Krishnan Sukumar, Clarissa Kai Hui Tan, Farhana Tukijan, Ludovic Couty, Zafrul Hasan, Ilaria Del Gaudio, Markus Wenk, Amaury Cazenave-Gassiot,  Eric Camerer, #Long N. Nguyen. Mfsd2b and Spns2 coordinate to provide S1P for development and protection from pathological conditions.  Cell Reports. Aug 2022. #Corresponding author.                                                                                                                                                                                                                                                    
  9. *Madhuvanthi Chandrakanthan, *Toan Quoc Nguyen1, *Zafrul Hasan, Sneha Muralidharan, Thiet Minh Vu, Aaron Wei Liang Li, Uyen Thanh Nha Le, Hoa Thi Thuy Ha, Sangha Baik, Sock Hwee Tan, Juat Chin Foo, Markus R. Wenk, Amaury Cazenave-Gassiot, Federico Torta, Wei Yi Ong, Mark Yan Yee Chan, #Long N. Nguyen. Deletion of Mfsd2b impairs thrombotic functions of platelets. Nature Communications. April 2021. #Corresponding author.                                                                                                                                                                                                                                                    
  10. *Toan Q. Nguyen, *Thiet Minh Vu, *Farhana Tukijan, Sneha Muralidharan, Juat Chin Foo, Jasmine Fei Li Chin, Zafrul Hasan, Federico Torta, #Long N. Nguyen. Erythrocytes efficiently utilize exogenous sphingosine for S1P synthesis and export via Mfsd2b. JBC. Jan 2021. #Corresponding author.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
  11. *Yen T. K. Nguyen, *Hoa T. T. Ha, *Tra H. Nguyen, #Long N. Nguyen. The roles of solute transporters for brain health and disease. Cellular and Molecular Life Sciences. 2021 Dec 31;79(1):20. #Corresponding author. IF=9.261.                                                                                                                                                                                                                                                    
  12. Shu Ting Tan, Tejasvene Ramesh, Xiu Ru Toh, #Long N. Nguyen. Emerging roles of lysolipids in health and disease. Progress in Lipid Research. Prog Lipid Res. 2020 Nov;80:101068. Invited Review. #Corresponding author. IF=16.195.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
  13. *Pazhanichamy Kalailingam, *Kai Qi Wang, *Xiu Ru Toh, *Toan Q. Nguyen, Madhuvanthi Chandrakanthan, Zafrul Hasan, Clair Habib, Aharon Schif, Francesca Clementina Radio4, Bruno Dallapiccola, Karin Weiss, #Long N. Nguyen. Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. Journal of Clinical Investigation. May 2020. *shared first authorship. #Corresponding author.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
  14. Turkijan F, Chandrakathan M, #Nguyen LN. The signaling role of S1P derived from red blood cells and platelets. Jul 2018. Invited mini-review. British Journal Pharmacology. IF = 8.739. #Corresponding author.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
  15. Vu, T. M., A.-N. Ishizu, J. C. Foo, X. R. Toh, F. Zhang, D. M. Whee, F. Torta, A. Cazenave-Gassiot, T. Matsumura, S. Kim, S.-A. E. S. Toh, T. Suda, D. L. Silver, M. R. Wenk and #Long N. Nguyen. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. Nature. October 2017 #corresponding author.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
  16. *Alicia Guemez-Gamboa, *Long N. Nguyen, Hongbo Yang, Maha S. Zaki, Majdi Kara, Tawfeg Ben-Omran, Naiara Akizu, Rasim Ozgur Rosti, Basak Rosti, Eric Scott, Jana Schroth, Brett Copeland, , Amaury Cazenave-Gassiot, Debra Quek, Bernice Wong, Markus R. Wenk, Murat Gunel, Stacey Gabriel, Neil Chi, #David L. Silver, #Joseph G. Gleeson. Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Result in Lethal Microcephaly Syndrome. Nature genetics, 2015. 47(7): p. 809. *Shared first authorship. *Co-first author. May 2015. IF: 38.33.                                                                                                                                                                                                                                                    
  17. Vafa Alakbarzade, Abdul Hameed, Debra Q.Y. Quek, Barry A. Chioza, Emma L. Baple, Amaury azenave-Gassiot, Long N. Nguyen, Markus R. Wenk, Arshia Q. Ahmad, Ajith Sreekantan-Nair, Michael N. Weedon, Phil Rich, Michael. A. Patton, Thomas T. Warner, David L. Silver, Andrew H. Crosby. A Partially Inactivating Mutation in the Sodium-Dependent Lysophosphatidylcholine Transporter MFSD2A causes a Non-lethal Microcephaly Syndrome. Nature genetics, 2015. 47(7): p. 814. IF: 38.33.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
  18. Long N. Nguyen, Dongliang Ma, Guanghou Shui, Peiyan Wong, Amaury Cazenave Gassiot, Xiaodong Zhang,, Markus R. Wenk, Eyleen L.K. Goh, and David L. Silver. (2014). Mfsd2a is a transporter for the essential omega-3 fatty acid DHA. Nature, 2014. 509 (7501): p. 503. Comments by Nature News and View; Neuron Previews; F1000. IF=49.962.
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