Affiliations
Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Supervisor, NUS Graduate School for Integrative Sciences and Engineering (NGS).
Education
| Degree and Institution | Year(s) |
| M.D. Humboldt University Berlin | 1996 |
Professional Experience
| Position and Institute | Year(s) |
| Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS | 2013 – present |
| Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS | 2007 – 2013 |
| Assistant Professor, Wolfson Digestive Diseases Centre, University of Nottingham, UK | 2003 – 2007 |
| Postdoctoral Research Fellow. Wolfson Institute for Biomedical Research, University College London, UK | 2001 – 2003 |
| Postdoctoral Research Fellow. Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline, UK | 2000 – 2001 |
| Postdoctoral Research Fellow. Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA | 1998 – 2000 |
| Postdoctoral Research Fellow. Departments of Genetics and Laboratory Medicine, Children’s Hospital, Harvard Medical School, USA | 1996 – 1998 |
Research Interest
* Cellular signaling and energy metabolism
* Cellular stress response
* Novel therapeutic approaches for obesity and cancer
Selected Publications
- SY Hong, T Hagen. Multiple myeloma Leu167Ile (c.499C>A) mutation prevents XBP1 mRNA splicing. Br. J. Haematol. 161:898-901 (2013)
- L Cordero-Espinoza, T Hagen. Increased concentrations of Fructose-2,6-bisphosphate contribute to the Warburg effect in PTEN-deficient cells. J. Biol. Chem. 288:36020-36008 (2013)
- SY Hong, FX Yu, Y Luo,T Hagen. Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein. Cell. Signal. 28:377-83 (2016)
- SY Hong, LT Ng, LF Ng, T Inoue, NS Tolwinski, T Hagen¶, J Gruber¶. The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing. PLoS One 11:e0168752 (2016)
- MY Ng, M Wang, PJ Casey, YH Gan, T Hagen. Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). PLoS One 12:e0171464 (2017)
- DPW Wong, MY Ng, JY Leung, BK Boh, EC Lim, SH Tan, S Lim, WH Seah, CZ Hu, BC Ho, DHP Ng, T Hagen. Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes. PLoS One 13:e0204853. (2018)